BP

GO:0001822

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

IEA

BP

GO:0002040

sprouting angiogenesis

The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.

ISS

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006355

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

IEA

BP

GO:0006397

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

IEA

BP

GO:0007166

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0007507

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

IEA

BP

GO:0008380

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

IEA

BP

GO:0018395

peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine

The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine.

IDA

BP

GO:0030324

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

IEA

BP

GO:0033077

T cell differentiation in thymus

The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.

IEA

BP

GO:0042116

macrophage activation

A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

IEA

BP

GO:0043654

recognition of apoptotic cell

The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.

IEA

BP

GO:0048024

regulation of mRNA splicing, via spliceosome

Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism.

IMP

BP

GO:0048821

erythrocyte development

The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.

IEA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

BP

GO:0060041

retina development in camera-type eye

The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

IEA

BP

GO:0070078

histone H3-R2 demethylation

The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone.

IDA

BP

GO:0070079

histone H4-R3 demethylation

The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0030529

intracellular ribonucleoprotein complex

An intracellular macromolecular complex containing both protein and RNA molecules.

IEA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

TAS

MF

GO:0003727

single-stranded RNA binding

Interacting selectively and non-covalently with single-stranded RNA.

IDA

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

IEA

MF

GO:0005506

iron ion binding

Interacting selectively and non-covalently with iron (Fe) ions.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0032452

histone demethylase activity

Catalysis of the removal of a methyl group from a histone.

TAS

MF

GO:0033746

histone demethylase activity (H3-R2 specific)

Catalysis of the removal of a methyl group from arginine at position 2 of the histone H3 protein.

IDA

MF

GO:0033749

histone demethylase activity (H4-R3 specific)

Catalysis of the removal of a methyl group from arginine at position 3 of the histone H4 protein.

IDA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IDA|IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IEA

MF

GO:0070815

peptidyl-lysine 5-dioxygenase activity

Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2.

IDA