BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IEA

BP

GO:0007018

microtubule-based movement

A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules.

IBA|ISS

BP

GO:0007270

neuron-neuron synaptic transmission

The process of communication from a neuron to another neuron across a synapse.

ISS

BP

GO:0007274

neuromuscular synaptic transmission

The process of communication from a neuron to a muscle, across a synapse.

ISS

BP

GO:0008089

anterograde axonal transport

The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.

ISS

BP

GO:0030705

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.

IBA|ISS

BP

GO:0047497

mitochondrion transport along microtubule

The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.

IEA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IEA

CC

GO:0005871

kinesin complex

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.

IBA

CC

GO:0005874

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

IEA

CC

GO:0005875

microtubule associated complex

Any multimeric complex connected to a microtubule.

ISS

CC

GO:0030659

cytoplasmic vesicle membrane

The lipid bilayer surrounding a cytoplasmic vesicle.

ISS

CC

GO:0031410

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

ISS

CC

GO:0043005

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

ISS

CC

GO:1904115

axon cytoplasm

Any cytoplasm that is part of a axon.

IEA

MF

GO:0003777

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

IBA|ISS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008017

microtubule binding

Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.

IEA

MF

GO:0016887

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.

IBA|ISS

MF

GO:0019894

kinesin binding

Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.

TAS