Protein Description

Gene Symbol RRP1B
Entrez ID 23076
Uniprot ID Q14684
Description ribosomal RNA processing 1B
Chromosomal Location chr21: 43,659,548-43,696,079
Ontology GO ID GO Term Definition Evidence

BP

GO:0006364

rRNA processing

Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

IBA

BP

GO:0010923

negative regulation of phosphatase activity

Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

IDA

CC

GO:0000791

euchromatin

A dispersed and relatively uncompacted form of chromatin.

IEA

CC

GO:0000792

heterochromatin

A compact and highly condensed form of chromatin.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA

CC

GO:0030687

preribosome, large subunit precursor

A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

IBA

CC

GO:0030688

preribosome, small subunit precursor

A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR010301

Nucleolar, Nop52

No pathways found.

UMLS CUI UMLS Term

C0341106

Eosinophilic Esophagitis

Tissue Cell Type

adrenal gland

glandular cells

breast

glandular cells

bronchus

respiratory epithelial cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

glial cells

kidney

cells in tubules

nasopharynx

respiratory epithelial cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

skeletal muscle

myocytes

skin

epidermal cells

testis

cells in seminiferous ducts

thyroid gland

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

SRSF1

6426

Q07955

0.63

SRSF6

6431

Q13247

0.63

LSM1

27257

O15116

0.63

CSNK2A1

1457

P68400

0.70

PARP1

142

P09874

0.72

IGKC

3514

P01834

0.72

ILF3

3609

Q12906

0.72

NCL

4691

P19338

0.72

RPL10A

4736

P62906

0.72

NPM1

4869

P06748

0.72

RPL4

6124

P36578

0.72

RPL5

6125

P46777

0.72

RPLP0

6175

P05388

0.72

TOP1

7150

P11387

0.72

CUBN

8029

O60494

0.72

YBX3

8531

P16989

0.72

PRPF4B

8899

Q13523

0.72

H1FX

8971

Q92522

0.72

DDX21

9188

Q9NR30

0.72

ALYREF

10189

Q86V81

0.72

RRP1B

23076

Q14684

0.72

LARP1

23367

Q6PKG0

0.72

SDF2L1

23753

Q9HCN8

0.72

RSL1D1

26156

O76021

0.72

IGKV2-40

28916

N/A

0.72

LUC7L2

51631

Q9Y383

0.72

LUC7L3

51747

O95232

0.72

SLC22A11

55867

Q9NSA0

0.72

HNRNPA1

3178

P09651

0.82

NUP107

57122

P57740

0.49

SRPK2

6733

P78362

0.52

TRIM28

10155

Q13263

0.52

CBX5

23468

P45973

0.52

ESR2

2100

Q92731

0.55

SUMO1

7341

P63165

0.56

ELAVL1

1994

Q15717

0.63

IFI16

3428

Q16666

0.63

ILF2

3608

Q12905

0.63

JUN

3725

P05412

0.63

MNDA

4332

P41218

0.63

MPG

4350

P29372

0.63

MYC

4609

P01106

0.63

NTRK1

4914

P04629

0.63

PPP1R3A

5506

Q16821

0.63

RNF2

6045

Q99496

0.63

ABCE1

6059

P61221

0.63

SUMO2

6613

P61956

0.63

TARBP2

6895

Q15633

0.63

TP53

7157

P04637

0.63

CUL3

8452

Q13618

0.63

RPL14

9045

P50914

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

SMNDC1

10285

O75940

0.63

OBSL1

23363

O75147

0.63

SIRT7

51547

Q9NRC8

0.63

PINX1

54984

Q96BK5

0.63

LYAR

55646

Q9NX58

0.63

CCDC8

83987

Q9H0W5

0.63

ESR1

2099

P03372

0.67

APOA1

335

P02647

0.72

MAPK14

1432

Q16539

0.72

CSNK2A2

1459

P19784

0.72

HDGF

3068

P51858

0.72

HNRNPU

3192

Q00839

0.72

SORT1

6272

Q99523

0.72

BAG6

7917

P46379

0.72

SRPK3

26576

Q9UPE1

0.72

PPP1CC

5501

P36873

0.87

PPP1CA

5499

P62136

0.89