PCOSBase

Protein Description

Gene Symbol	CFL1
Entrez ID	1072
Uniprot ID	P23528
Description	cofilin 1 (non-muscle)
Chromosomal Location	chr11: 65,823,022-65,862,026

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0007010	cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.	IMP
BP	GO:0007266	Rho protein signal transduction	A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.	TAS
BP	GO:0009615	response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.	IEP
BP	GO:0022604	regulation of cell morphogenesis	Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.	IMP
BP	GO:0030036	actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.	TAS
BP	GO:0030042	actin filament depolymerization	Disassembly of actin filaments by the removal of actin monomers from a filament.	IDA
BP	GO:0043066	negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.	TAS
BP	GO:0044794	positive regulation by host of viral process	A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.	IMP
BP	GO:0061001	regulation of dendritic spine morphogenesis	Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.	IMP
CC	GO:0005615	extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA\|TAS
CC	GO:0005925	focal adhesion	Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.	IDA
CC	GO:0015629	actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.	IEA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0016363	nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.	IEA
CC	GO:0031012	extracellular matrix	A structure lying external to one or more cells, which provides structural support for cells or tissues.	IDA
CC	GO:0031258	lamellipodium membrane	The portion of the plasma membrane surrounding a lamellipodium.	IEA
CC	GO:0031982	vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.	IDA
CC	GO:0032587	ruffle membrane	The portion of the plasma membrane surrounding a ruffle.	IEA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0051015	actin filament binding	Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.	IDA\|ISS

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Domain ID	Description
IPR002108	Actin-depolymerising factor homology domain
IPR017904	ADF/Cofilin
IPR027234	Cofilin 1
IPR029006	ADF-H/Gelsolin-like domain

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Pathway ID	Pathway Term	Pathway Source
hsa04360	Axon guidance	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05133	Pertussis	KEGG
WP437	EGF/EGFR Signaling Pathway	WikiPathways
WP51	Regulation of Actin Cytoskeleton	WikiPathways
WP524	G13 Signaling Pathway	WikiPathways
WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	WikiPathways
WP3888	VEGFA-VEGFR2 Signaling Pathway	WikiPathways
h_CCR3Pathway	CCR3 signaling in Eosinophils	BioCarta
h_rac1Pathway	Rac 1 cell motility signaling pathway	BioCarta
h_rhoPathway	Rho cell motility signaling pathway	BioCarta

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UMLS CUI	UMLS Term
C0027626	Neoplasm Invasiveness
C0027627	Neoplasm Metastasis
C0032927	Precancerous Conditions
C0080178	Spina Bifida
C1458155	Mammary Neoplasms

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Tissue	Cell Type
appendix	glandular cells
colon	glandular cells
duodenum	glandular cells
lymph node	germinal center cells
lymph node	non-germinal center cells
rectum	glandular cells
small intestine	glandular cells
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells

No databases found.

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Pubmed ID	Author	Year	Title
17900306	Borro et al.	2007	Proteomic analysis of peripheral T lymphocytes, suitable circulating biosensors of strictly related diseases
19820292	Misti et al.	2010	Proteomic profiles in hyperandrogenic syndromes
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
ABAT	18	P80404	0.49
ALDOA	226	P04075	0.49
CAT	847	P04040	0.49
CSRP1	1465	P21291	0.49
ENO1	2023	P06733	0.49
GAPDH	2597	P04406	0.49
HSPE1	3336	P61604	0.49
LDHA	3939	P00338	0.49
LDHB	3945	P07195	0.49
PEBP1	5037	P30086	0.49
PIN1	5300	Q13526	0.49
PKM	5315	P14618	0.49
TKT	7086	P29401	0.49
PUDP	8226	Q08623	0.49
TAGLN2	8407	P37802	0.49
ALDH4A1	8659	P30038	0.49
POLR1C	9533	O15160	0.49
COX17	10063	Q14061	0.49
TRAP1	10131	Q12931	0.49
AKR1A1	10327	P14550	0.49
ACAA2	10449	P42765	0.49
LYPLA2	11313	O95372	0.49
DBNL	28988	Q9UJU6	0.49
HN1	51155	Q9UK76	0.49
UFM1	51569	P61960	0.49
RTN4	57142	Q9NQC3	0.49
FAHD1	81889	Q6P587	0.49
TANGO2	128989	Q6ICL3	0.49
LDHAL6A	160287	Q6ZMR3	0.49
ARF4	378	P18085	0.56
DUT	1854	P33316	0.56
MDH2	4191	P40926	0.56
NME1	4830	P15531	0.56
NME2	4831	P22392	0.56
PRDX1	5052	Q06830	0.56
PPIA	5478	P62937	0.56
UBA52	7311	P62987	0.56
UFD1L	7353	Q92890	0.56
PRDX5	25824	P30044	0.56
YWHAG	7532	P61981	0.59
ERBB4	2066	Q15303	0.63
MTAP	4507	Q13126	0.63
PSEN1	5663	P49768	0.63
SUGT1	10910	Q9Y2Z0	0.63
CLCN5	1184	P51795	0.67
ACTA2	59	P62736	0.70
ACTC1	70	P68032	0.70
PLD1	5337	Q13393	0.70
CAP2	10486	P40123	0.70
ROCK1	6093	Q13464	0.72
CFL2	1073	Q9Y281	0.73
MYCBP	26292	Q99417	0.73
ATXN1	6310	P54253	0.75
TAGLN	6876	Q01995	0.76
ATP1A1	476	P05023	0.77
TPI1	7167	P60174	0.84
ACTA1	58	P68133	0.89
YWHAZ	7534	P63104	0.89
CAP1	10487	Q01518	0.89
CAPG	822	P40121	0.49
SERPINH1	871	P50454	0.49
CRIP1	1396	P50238	0.49
EIF4B	1975	P23588	0.49
GPT	2875	P24298	0.49
HSPA9	3313	P38646	0.49
PCBP1	5093	Q15365	0.49
PFN1	5216	P07737	0.49
NUP214	8021	P35658	0.49
PIR	8544	O00625	0.49
DYNLL1	8655	P63167	0.49
RAB10	10890	P61026	0.49
PTGR1	22949	Q14914	0.49
COTL1	23406	Q14019	0.49
DAZAP1	26528	Q96EP5	0.49
GPT2	84706	Q8TD30	0.49
SRXN1	140809	Q9BYN0	0.49
SRC	6714	P12931	0.52
NRK	203447	Q7Z2Y5	0.55
CKS2	1164	P33552	0.56
GRB2	2885	P62993	0.56
PTEN	5728	P60484	0.56
SOD1	6647	P00441	0.56
KYNU	8942	Q16719	0.56
UCHL5	51377	Q9Y5K5	0.56
SLC2A4	6517	P14672	0.59
APP	351	P05067	0.63
CD81	975	P60033	0.63
CDK2	1017	P24941	0.63
CFTR	1080	P13569	0.63
ECT2	1894	Q9H8V3	0.63
FUS	2521	P35637	0.63
GJA1	2697	P17302	0.63
GRK5	2869	P34947	0.63
HNRNPA1	3178	P09651	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MDM2	4193	Q00987	0.63
MYC	4609	P01106	0.63
NEDD8	4738	Q15843	0.63
NFKB1	4790	P19838	0.63
NPM1	4869	P06748	0.63
NTRK1	4914	P04629	0.63
PRKCZ	5590	Q05513	0.63
MAPK6	5597	Q16659	0.63
RAD21	5885	O60216	0.63
RPS6KA1	6195	Q15418	0.63
RPS6KB2	6199	Q9UBS0	0.63
SUMO2	6613	P61956	0.63
EED	8726	O75530	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
PTBP3	9991	O95758	0.63
TAB1	10454	Q15750	0.63
MAPK8IP2	23542	Q13387	0.63
GABARAPL1	23710	Q9H0R8	0.63
FBXO25	26260	Q8TCJ0	0.63
SSH3	54961	Q8TE77	0.63
SMURF1	57154	Q9HCE7	0.63
HECW2	57520	Q9P2P5	0.63
MAP1LC3A	84557	Q9H492	0.63
SSH2	85464	Q76I76	0.63
TRIM15	89870	Q9C019	0.63
IGSF8	93185	Q969P0	0.63
TESK1	7016	Q15569	0.66
TESK2	10420	Q96S53	0.66
PLD2	5338	O14939	0.68
PRKACA	5566	P17612	0.68
YWHAQ	10971	P27348	0.68
EIF6	3692	P56537	0.70
MCM2	4171	P49736	0.70
MCM5	4174	P33992	0.70
SSH1	54434	Q8WYL5	0.70
ATF2	1386	P15336	0.72
DBN1	1627	Q16643	0.72
FLNA	2316	P21333	0.72
FN1	2335	P02751	0.72
MYH9	4627	P35579	0.72
MYO1C	4641	O00159	0.72
PPP1CB	5500	P62140	0.72
RAB7A	7879	P51149	0.72
IQGAP1	8826	P46940	0.72
ACTR2	10097	P61160	0.72
SYNPO	11346	Q8N3V7	0.72
LIMA1	51474	Q9UHB6	0.72
ANLN	54443	Q9NQW6	0.72
MYO19	80179	Q96H55	0.72
TXNDC17	84817	Q9BRA2	0.72
MYO18A	399687	Q92614	0.72
TERF1	7013	P54274	0.73
ISG15	9636	P05161	0.73
POT1	25913	Q9NUX5	0.73
CAPZA2	830	P47755	0.79
ACTB	60	P60709	0.80
ACTG1	71	P63261	0.80
H2AFX	3014	P16104	0.80
EGFR	1956	P00533	0.82
ESR1	2099	P03372	0.82
VCAM1	7412	P19320	0.82
WDR1	9948	O75083	0.82
LIMK2	3985	P53671	0.85
ARRB1	408	P49407	0.86
ARRB2	409	P32121	0.86
LIMK1	3984	P53667	0.87
HSPH1	10808	Q92598	0.95