BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|ISS

BP

GO:0000904

cell morphogenesis involved in differentiation

The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

IEA

BP

GO:0001706

endoderm formation

The formation of the endoderm during gastrulation.

IEA

BP

GO:0001707

mesoderm formation

The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

IEA

BP

GO:0001942

hair follicle development

The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.

IEA

BP

GO:0002090

regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.

IDA

BP

GO:0030178

negative regulation of Wnt signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.

IDA

BP

GO:0030326

embryonic limb morphogenesis

The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.

IEA

BP

GO:0030514

negative regulation of BMP signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

IEA

BP

GO:0030900

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

IEA

BP

GO:0032091

negative regulation of protein binding

Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

IDA

BP

GO:0032526

response to retinoic acid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

IEA

BP

GO:0033137

negative regulation of peptidyl-serine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IDA

BP

GO:0042662

negative regulation of mesodermal cell fate specification

Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.

IDA

BP

GO:0042663

regulation of endodermal cell fate specification

Any process that mediates the specification of a cell into an endoderm cell.

IDA

BP

GO:0048642

negative regulation of skeletal muscle tissue development

Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.

IEA

BP

GO:0050807

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

IEA

BP

GO:0051966

regulation of synaptic transmission, glutamatergic

Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

IEA

BP

GO:0060325

face morphogenesis

The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.

IEA

BP

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

IDA

BP

GO:0061743

motor learning

Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.

IEA

BP

GO:0090082

positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway

Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

ISS

BP

GO:0090090

negative regulation of canonical Wnt signaling pathway

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

IDA|IGI|NAS|TAS

BP

GO:0090244

Wnt signaling pathway involved in somitogenesis

The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.

IEA

BP

GO:0098883

synapse disassembly

A cellular process that results in the controlled breakdown of synapse.

TAS

BP

GO:1900116

extracellular negative regulation of signal transduction

Any negative regulation of signal transduction that takes place in extracellular region.

IEA

BP

GO:1901296

negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

Any process that stops, prevents or reduces the frequency, rate or extent of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment.

IDA

BP

GO:1904338

regulation of dopaminergic neuron differentiation

Any process that modulates the frequency, rate or extent of dopaminergic neuron differentiation.

TAS

BP

GO:1904723

negative regulation of Wnt-Frizzled-LRP5/6 complex assembly

Any process that stops, prevents or reduces the frequency, rate or extent of Wnt-Frizzled-LRP5/6 complex assembly.

IDA|IPI

BP

GO:1904958

positive regulation of midbrain dopaminergic neuron differentiation

Any process that activates or increases the frequency, rate or extent of midbrain dopaminergic neuron differentiation.

IEA

BP

GO:2000726

negative regulation of cardiac muscle cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0031901

early endosome membrane

The lipid bilayer surrounding an early endosome.

TAS

MF

GO:0004871

signal transducer activity

Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

TAS

MF

GO:0039706

co-receptor binding

Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.

IPI|TAS

MF

GO:0048019

receptor antagonist activity

Interacts with receptors to reduce the action of another ligand, the agonist.

IDA

MF

GO:0050750

low-density lipoprotein particle receptor binding

Interacting selectively and non-covalently with a low-density lipoprotein receptor.

IDA