| Gene Symbol | SEPHS1 |
| Entrez ID | 22929 |
| Uniprot ID | P49903 |
| Description | selenophosphate synthetase 1 |
| Chromosomal Location | chr10: 13,317,424-13,348,298 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006464 | cellular protein modification process |
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). | TAS |
BP | GO:0016310 | phosphorylation |
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. | IEA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IEA |
CC | GO:0005886 | plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | IEA |
CC | GO:0031965 | nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. | IEA |
MF | GO:0004756 | selenide, water dikinase activity |
Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. | IEA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IEA |
MF | GO:0005525 | GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. | TAS |
MF | GO:0042802 | identical protein binding |
Interacting selectively and non-covalently with an identical protein or proteins. | IPI |
| Domain ID | Description |
|---|---|
IPR004536 | Selenophosphate synthetase |
IPR010918 | AIR synthase-related protein, C-terminal domain |
IPR016188 | PurM-like, N-terminal domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00450 | Selenocompound metabolism | KEGG |
hsa01100 | Metabolic pathways | KEGG |
WP28 | Selenium Metabolism and Selenoproteins | WikiPathways |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
breast | adipocytes |
breast | glandular cells |
breast | myoepithelial cells |
bronchus | respiratory epithelial cells |
cerebral cortex | neuronal cells |
cervix, uterine | glandular cells |
cervix, uterine | squamous epithelial cells |
colon | endothelial cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | glandular cells |
endometrium | cells in endometrial stroma |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
pancreas | exocrine glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skin | fibroblasts |
skin | keratinocytes |
skin | Langerhans |
skin | melanocytes |
skin | epidermal cells |
small intestine | glandular cells |
soft tissue | adipocytes |
soft tissue | fibroblasts |
soft tissue | peripheral nerve |
soft tissue | chondrocytes |
stomach | glandular cells |
testis | cells in seminiferous ducts |
testis | Leydig cells |
thyroid gland | glandular cells |
tonsil | non-germinal center cells |
urinary bladder | urothelial cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
ACADS | 35 | P16219 | 0.49 |
CRKL | 1399 | P46109 | 0.49 |
G6PD | 2539 | P11413 | 0.49 |
HSPB1 | 3315 | P04792 | 0.49 |
SEC13 | 6396 | P55735 | 0.49 |
TPD52 | 7163 | P55327 | 0.49 |
TUFM | 7284 | P49411 | 0.49 |
PDCD6 | 10016 | O75340 | 0.49 |
SUGT1 | 10910 | Q9Y2Z0 | 0.49 |
XPO7 | 23039 | Q9UIA9 | 0.49 |
RTCB | 51493 | Q9Y3I0 | 0.49 |
DDX19A | 55308 | Q9NUU7 | 0.49 |
MCFD2 | 90411 | Q8NI22 | 0.49 |
WDR12 | 55759 | Q9GZL7 | 0.59 |
CRMP1 | 1400 | Q14194 | 0.63 |
C14orf1 | 11161 | Q9UKR5 | 0.63 |
QRICH1 | 54870 | Q2TAL8 | 0.63 |
SLC35F6 | 54978 | Q8N357 | 0.63 |
IGSF21 | 84966 | Q96ID5 | 0.63 |
DEPDC7 | 91614 | Q96QD5 | 0.63 |
GBP7 | 388646 | Q8N8V2 | 0.63 |
ZBTB25 | 7597 | P24278 | 0.73 |
SEPHS1 | 22929 | P49903 | 0.74 |
CLIC1 | 1192 | O00299 | 0.49 |
ECH1 | 1891 | Q13011 | 0.49 |
FDPS | 2224 | P14324 | 0.49 |
PTPRF | 5792 | P10586 | 0.49 |
UMPS | 7372 | P11172 | 0.49 |
XPO1 | 7514 | O14980 | 0.49 |
COPS2 | 9318 | P61201 | 0.49 |
AHCYL1 | 10768 | O43865 | 0.49 |
DIS3 | 22894 | Q9Y2L1 | 0.49 |
HYPK | 25764 | Q9NX55 | 0.49 |
CLIC4 | 25932 | Q9Y696 | 0.49 |
REXO2 | 25996 | Q9Y3B8 | 0.49 |
MAT2B | 27430 | Q9NZL9 | 0.49 |
PPIL3 | 53938 | Q9H2H8 | 0.49 |
PIPSL | 266971 | A2A3N6 | 0.49 |
GART | 2618 | P22102 | 0.59 |
PFAS | 5198 | O15067 | 0.59 |
PUM1 | 9698 | Q14671 | 0.59 |
CNN3 | 1266 | Q15417 | 0.63 |
ELAVL1 | 1994 | Q15717 | 0.63 |
GBP2 | 2634 | P32456 | 0.63 |
SAT1 | 6303 | P21673 | 0.63 |
SOX2 | 6657 | P48431 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
TNFRSF10D | 8793 | Q9UBN6 | 0.63 |
UNC119 | 9094 | Q13432 | 0.63 |
EIF1B | 10289 | O60739 | 0.63 |
SPACA9 | 11092 | Q96E40 | 0.63 |
CDCA4 | 55038 | Q9BXL8 | 0.63 |
CCDC130 | 81576 | P13994 | 0.63 |
TAS2R41 | 259287 | P59536 | 0.63 |