Protein Description

Gene Symbol MGAT4B
Entrez ID 11282
Uniprot ID Q9UQ53
Description mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Chromosomal Location chr5: 179,797,597-179,806,952
Ontology GO ID GO Term Definition Evidence

BP

GO:0006491

N-glycan processing

The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.

TAS

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0008454

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.

TAS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR006759

Glycosyl transferase family 54

Pathway ID Pathway Term Pathway Source

hsa00510

N-Glycan biosynthesis

KEGG

hsa01100

Metabolic pathways

KEGG

No diseases found.

Tissue Cell Type

kidney

cells in tubules

placenta

trophoblastic cells

spleen

cells in red pulp

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

SLC26A2

1836

P50443

0.49

UQCRFS1

7386

P47985

0.49

VDAC1

7416

P21796

0.49

SYNJ2BP

55333

P57105

0.49

SFXN2

118980

Q96NB2

0.49

ATP6V0A1

535

Q93050

0.63

HBB

3043

P68871

0.63

LRSAM1

90678

Q6UWE0

0.73

PLAUR

5329

Q03405

0.63