BP

GO:0001578

microtubule bundle formation

A process that results in a parallel arrangement of microtubules.

ISS

BP

GO:0001933

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

ISS

BP

GO:0006469

negative regulation of protein kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

ISS

BP

GO:0006611

protein export from nucleus

The directed movement of a protein from the nucleus into the cytoplasm.

ISS

BP

GO:0006813

potassium ion transport

The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

TAS

BP

GO:0007264

small GTPase mediated signal transduction

Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.

TAS

BP

GO:0010923

negative regulation of phosphatase activity

Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

IDA

BP

GO:0017156

calcium ion regulated exocytosis

The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.

IEA

BP

GO:0022406

membrane docking

The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.

ISS

BP

GO:0030214

hyaluronan catabolic process

The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

TAS

BP

GO:0031122

cytoplasmic microtubule organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.

ISS

BP

GO:0031397

negative regulation of protein ubiquitination

Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.

ISS

BP

GO:0031953

negative regulation of protein autophosphorylation

Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.

ISS

BP

GO:0032088

negative regulation of NF-kappaB transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.

IDA

BP

GO:0032417

positive regulation of sodium:proton antiporter activity

Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).

IDA|ISS

BP

GO:0042308

negative regulation of protein import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.

IDA

BP

GO:0050821

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

ISS

BP

GO:0051222

positive regulation of protein transport

Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ISS

BP

GO:0051259

protein oligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IEA

BP

GO:0051453

regulation of intracellular pH

Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.

IDA

BP

GO:0060050

positive regulation of protein glycosylation

Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

ISS

BP

GO:0061024

membrane organization

A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ISS

BP

GO:0061025

membrane fusion

The membrane organization process that joins two lipid bilayers to form a single membrane.

ISS

BP

GO:0070885

negative regulation of calcineurin-NFAT signaling cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade.

IDA

BP

GO:0071468

cellular response to acidic pH

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.

ISS

BP

GO:0090314

positive regulation of protein targeting to membrane

Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

ISS

BP

GO:1901214

regulation of neuron death

Any process that modulates the frequency, rate or extent of neuron death.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

ISS

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

ISS

CC

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0015630

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

ISS

CC

GO:0030133

transport vesicle

Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

ISS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004860

protein kinase inhibitor activity

Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

IEA

MF

GO:0005215

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.

ISS

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008017

microtubule binding

Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.

ISS

MF

GO:0015459

potassium channel regulator activity

Modulates the activity of a potassium channel.

TAS

MF

GO:0019900

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

ISS

MF

GO:0048306

calcium-dependent protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.

IDA