Gene Symbol | NUDT3 |
Entrez ID | 11165 |
Uniprot ID | O95989 |
Description | nudix hydrolase 3 |
Chromosomal Location | chr6: 34,279,679-34,392,674 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007267 |
cell-cell signaling |
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
TAS |
BP |
GO:0015961 |
diadenosine polyphosphate catabolic process |
The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached. |
TAS |
BP |
GO:0043647 |
inositol phosphate metabolic process |
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. |
TAS |
BP |
GO:0071544 |
diphosphoinositol polyphosphate catabolic process |
The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached. |
IDA |
BP |
GO:1901907 |
diadenosine pentaphosphate catabolic process |
The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate. |
IBA |
BP |
GO:1901909 |
diadenosine hexaphosphate catabolic process |
The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate. |
IBA |
BP |
GO:1901911 |
adenosine 5'-(hexahydrogen pentaphosphate) catabolic process |
The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate). |
IBA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IBA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
MF |
GO:0000298 |
endopolyphosphatase activity |
Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. |
IBA |
MF |
GO:0008486 |
diphosphoinositol-polyphosphate diphosphatase activity |
Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. |
IDA |
MF |
GO:0034431 |
bis(5'-adenosyl)-hexaphosphatase activity |
Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate. |
IBA |
MF |
GO:0034432 |
bis(5'-adenosyl)-pentaphosphatase activity |
Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. |
IBA |
MF |
GO:0050072 |
m7G(5')pppN diphosphatase activity |
Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. |
IBA |
MF |
GO:0052840 |
inositol diphosphate tetrakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. |
IEA |
MF |
GO:0052841 |
inositol bisdiphosphate tetrakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate. |
TAS |
MF |
GO:0052842 |
inositol diphosphate pentakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. |
TAS |
MF |
GO:0052843 |
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
IEA |
MF |
GO:0052844 |
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
IEA |
MF |
GO:0052845 |
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. |
IEA |
MF |
GO:0052846 |
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+. |
IEA |
MF |
GO:0052847 |
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+. |
IEA |
MF |
GO:0052848 |
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+. |
IEA |
Domain ID | Description |
---|---|
IPR000086 |
NUDIX hydrolase domain |
IPR015797 |
NUDIX hydrolase domain-like |
IPR020084 |
NUDIX hydrolase, conserved site |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
cervix, uterine |
squamous epithelial cells |
skin |
keratinocytes |
skin |
epidermal cells |
spleen |
cells in red pulp |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ALAS1 |
211 |
P13196 |
0.63 |
APEX1 |
328 |
P27695 |
0.63 |
VPS51 |
738 |
Q9UID3 |
0.63 |
DDR1 |
780 |
Q08345 |
0.63 |
DBN1 |
1627 |
Q16643 |
0.63 |
EEF1G |
1937 |
P26641 |
0.63 |
HES1 |
3280 |
Q14469 |
0.63 |
DNAJA1 |
3301 |
P31689 |
0.63 |
MCM5 |
4174 |
P33992 |
0.63 |
OAT |
4942 |
P04181 |
0.63 |
FXYD3 |
5349 |
Q14802 |
0.63 |
PEX5 |
5830 |
P50542 |
0.63 |
RPL8 |
6132 |
P62917 |
0.63 |
RPL17 |
6139 |
P18621 |
0.63 |
CCL11 |
6356 |
P51671 |
0.63 |
TNNT3 |
7140 |
P45378 |
0.63 |
NR2C1 |
7181 |
P13056 |
0.63 |
XPNPEP1 |
7511 |
Q9NQW7 |
0.63 |
TUBA1A |
7846 |
Q71U36 |
0.63 |
REEP5 |
7905 |
Q00765 |
0.63 |
PDCD5 |
9141 |
O14737 |
0.63 |
NUDT5 |
11164 |
Q9UKK9 |
0.63 |
ARL6IP1 |
23204 |
Q15041 |
0.63 |
PRKD3 |
23683 |
O94806 |
0.63 |
TUBGCP4 |
27229 |
Q9UGJ1 |
0.63 |
WDR74 |
54663 |
Q6RFH5 |
0.63 |
CHCHD3 |
54927 |
Q9NX63 |
0.63 |
RNF126 |
55658 |
Q9BV68 |
0.63 |
RAB17 |
64284 |
Q9H0T7 |
0.63 |
ITFG1 |
81533 |
Q8TB96 |
0.63 |
MEX3B |
84206 |
Q6ZN04 |
0.63 |
MAF1 |
84232 |
Q9H063 |
0.63 |
UBR1 |
197131 |
Q8IWV7 |
0.63 |
ASB13 |
79754 |
Q8WXK3 |
0.73 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
MOV10 |
4343 |
Q9HCE1 |
0.63 |
NXF1 |
10482 |
Q9UBU9 |
0.63 |
SOX30 |
11063 |
O94993 |
0.63 |
AP1S2 |
8905 |
P56377 |
0.72 |
IQCB1 |
9657 |
Q15051 |
0.72 |
RPLP1 |
6176 |
P05386 |
0.73 |