Protein Description

Gene Symbol NUDT3
Entrez ID 11165
Uniprot ID O95989
Description nudix hydrolase 3
Chromosomal Location chr6: 34,279,679-34,392,674
Ontology GO ID GO Term Definition Evidence

BP

GO:0007267

cell-cell signaling

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

TAS

BP

GO:0015961

diadenosine polyphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached.

TAS

BP

GO:0043647

inositol phosphate metabolic process

The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

TAS

BP

GO:0071544

diphosphoinositol polyphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of a diphosphoinositol polyphosphate, 1,2,3,4,5,6-cyclohexanehexol with one or more diphosphate groups and multiple monophosphate groups attached.

IDA

BP

GO:1901907

diadenosine pentaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine pentaphosphate.

IBA

BP

GO:1901909

diadenosine hexaphosphate catabolic process

The chemical reactions and pathways resulting in the breakdown of diadenosine hexaphosphate.

IBA

BP

GO:1901911

adenosine 5'-(hexahydrogen pentaphosphate) catabolic process

The chemical reactions and pathways resulting in the breakdown of adenosine 5'-(hexahydrogen pentaphosphate).

IBA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IBA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0000298

endopolyphosphatase activity

Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.

IBA

MF

GO:0008486

diphosphoinositol-polyphosphate diphosphatase activity

Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.

IDA

MF

GO:0034431

bis(5'-adenosyl)-hexaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate.

IBA

MF

GO:0034432

bis(5'-adenosyl)-pentaphosphatase activity

Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.

IBA

MF

GO:0050072

m7G(5')pppN diphosphatase activity

Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.

IBA

MF

GO:0052840

inositol diphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate.

IEA

MF

GO:0052841

inositol bisdiphosphate tetrakisphosphate diphosphatase activity

Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate.

TAS

MF

GO:0052842

inositol diphosphate pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate.

TAS

MF

GO:0052843

inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

IEA

MF

GO:0052844

inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

IEA

MF

GO:0052845

inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity

Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.

IEA

MF

GO:0052846

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+.

IEA

MF

GO:0052847

inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+.

IEA

MF

GO:0052848

inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity

Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+.

IEA

Domain ID Description

IPR000086

NUDIX hydrolase domain

IPR015797

NUDIX hydrolase domain-like

IPR020084

NUDIX hydrolase, conserved site

No pathways found.

No diseases found.

Tissue Cell Type

bone marrow

hematopoietic cells

cervix, uterine

squamous epithelial cells

skin

keratinocytes

skin

epidermal cells

spleen

cells in red pulp

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

12734205

Wood et al.

2003

The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis

Gene Symbol Entrez ID Uniprot ID Score

ALAS1

211

P13196

0.63

APEX1

328

P27695

0.63

VPS51

738

Q9UID3

0.63

DDR1

780

Q08345

0.63

DBN1

1627

Q16643

0.63

EEF1G

1937

P26641

0.63

HES1

3280

Q14469

0.63

DNAJA1

3301

P31689

0.63

MCM5

4174

P33992

0.63

OAT

4942

P04181

0.63

FXYD3

5349

Q14802

0.63

PEX5

5830

P50542

0.63

RPL8

6132

P62917

0.63

RPL17

6139

P18621

0.63

CCL11

6356

P51671

0.63

TNNT3

7140

P45378

0.63

NR2C1

7181

P13056

0.63

XPNPEP1

7511

Q9NQW7

0.63

TUBA1A

7846

Q71U36

0.63

REEP5

7905

Q00765

0.63

PDCD5

9141

O14737

0.63

NUDT5

11164

Q9UKK9

0.63

ARL6IP1

23204

Q15041

0.63

PRKD3

23683

O94806

0.63

TUBGCP4

27229

Q9UGJ1

0.63

WDR74

54663

Q6RFH5

0.63

CHCHD3

54927

Q9NX63

0.63

RNF126

55658

Q9BV68

0.63

RAB17

64284

Q9H0T7

0.63

ITFG1

81533

Q8TB96

0.63

MEX3B

84206

Q6ZN04

0.63

MAF1

84232

Q9H063

0.63

UBR1

197131

Q8IWV7

0.63

ASB13

79754

Q8WXK3

0.73

ELAVL1

1994

Q15717

0.63

MOV10

4343

Q9HCE1

0.63

NXF1

10482

Q9UBU9

0.63

SOX30

11063

O94993

0.63

AP1S2

8905

P56377

0.72

IQCB1

9657

Q15051

0.72

RPLP1

6176

P05386

0.73