PCOSBase

Protein Description

Gene Symbol	AP4S1
Entrez ID	11154
Uniprot ID	Q9Y587
Description	adaptor related protein complex 4, sigma 1 subunit
Chromosomal Location	chr14: 31,025,106-31,096,450

Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0015031	protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	IEA
CC	GO:0005905	clathrin-coated pit	A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.	IEA
CC	GO:0031904	endosome lumen	The volume enclosed by the membrane of an endosome.	TAS
CC	GO:0032588	trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.	TAS
MF	GO:0005215	transporter activity	Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.	TAS
MF	GO:0008565	protein transporter activity	Enables the directed movement of proteins into, out of or within a cell, or between cells.	IEA

Domain ID	Description
IPR011012	Longin-like domain
IPR016635	Adaptor protein complex, sigma subunit
IPR022775	AP complex, mu/sigma subunit

Pathway ID	Pathway Term	Pathway Source
hsa04142	Lysosome	KEGG

Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
APP	351	P05067	0.56
AFP	174	P02771	0.63
GTF2I	2969	P78347	0.63
RPL10	6134	P27635	0.63
TMPO	7112	P42166	0.63
TMPO	7112	P42167	0.63
GALNT2	2590	Q10471	0.72
MECP2	4204	P51608	0.72
SLC9A1	6548	P19634	0.72
HLTF	6596	Q14527	0.72
AP4M1	9179	O00189	0.72
APPBP2	10513	Q92624	0.72
AP4B1	10717	Q9Y6B7	0.72
GOLIM4	27333	O00461	0.72
CDC73	79577	Q6P1J9	0.72
C19orf52	90580	Q9BSF4	0.72
CEP104	9731	O60308	0.49
ENTHD2	146705	Q96N21	0.63
GRB2	2885	P62993	0.63
TEAD3	7005	Q99594	0.63
AP4E1	23431	Q9UPM8	0.86