Protein Description

Gene Symbol CDKN1A
Entrez ID 1026
Uniprot ID P38936
Description cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Chromosomal Location chr6: 36,676,460-36,687,339
Ontology GO ID GO Term Definition Evidence

BP

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

TAS

BP

GO:0000082

G1/S transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

IDA|TAS

BP

GO:0000086

G2/M transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.

IMP

BP

GO:0006974

cellular response to DNA damage stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

IMP

BP

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

IDA|TAS

BP

GO:0007050

cell cycle arrest

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

IDA|IMP

BP

GO:0007265

Ras protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

IEP

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IDA|IMP

BP

GO:0009636

response to toxic substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

IEA

BP

GO:0010165

response to X-ray

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).

IEA

BP

GO:0010243

response to organonitrogen compound

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.

IEA

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IEA

BP

GO:0030308

negative regulation of cell growth

Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.

IDA

BP

GO:0030890

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

IEA

BP

GO:0031100

animal organ regeneration

The regrowth of a lost or destroyed animal organ.

IEA

BP

GO:0031668

cellular response to extracellular stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

IMP

BP

GO:0033158

regulation of protein import into nucleus, translocation

Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane.

IEA

BP

GO:0034198

cellular response to amino acid starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.

IMP

BP

GO:0034605

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

IEA

BP

GO:0042326

negative regulation of phosphorylation

Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.

IDA

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

IEA

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IEA

BP

GO:0043068

positive regulation of programmed cell death

Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

IEA

BP

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

IEA

BP

GO:0045860

positive regulation of protein kinase activity

Any process that activates or increases the frequency, rate or extent of protein kinase activity.

IDA

BP

GO:0046685

response to arsenic-containing substance

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

IEA

BP

GO:0048146

positive regulation of fibroblast proliferation

Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

IMP

BP

GO:0050821

protein stabilization

Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

TAS

BP

GO:0051412

response to corticosterone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.

IEA

BP

GO:0055093

response to hyperoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.

IEA

BP

GO:0060574

intestinal epithelial cell maturation

The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.

IEA

BP

GO:0071479

cellular response to ionizing radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

IMP

BP

GO:0071493

cellular response to UV-B

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.

ISS

BP

GO:0071850

mitotic cell cycle arrest

The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).

IEA

BP

GO:0090398

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

IMP

BP

GO:0090399

replicative senescence

A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.

IEA

BP

GO:0090400

stress-induced premature senescence

A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.

TAS

BP

GO:0097193

intrinsic apoptotic signaling pathway

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).

TAS

BP

GO:1904031

positive regulation of cyclin-dependent protein kinase activity

Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity.

IEA

BP

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle.

IGI

BP

GO:2000278

regulation of DNA biosynthetic process

Any process that modulates the frequency, rate or extent of DNA biosynthetic process.

IEA

BP

GO:2000379

positive regulation of reactive oxygen species metabolic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.

IMP

CC

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0070557

PCNA-p21 complex

A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.

IDA

MF

GO:0004861

cyclin-dependent protein serine/threonine kinase inhibitor activity

Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019912

cyclin-dependent protein kinase activating kinase activity

Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).

IDA

MF

GO:0030332

cyclin binding

Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.

IEA

MF

GO:0031625

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

IPI

MF

GO:0032403

protein complex binding

Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR003175

Cyclin-dependent kinase inhibitor

IPR029841

Cyclin-dependent kinase inhibitor 1, vertebrate

Pathway ID Pathway Term Pathway Source

hsa01522

Endocrine resistance

KEGG

hsa01524

Platinum drug resistance

KEGG

hsa04012

ErbB signaling pathway

KEGG

hsa04066

HIF-1 signaling pathway

KEGG

hsa04068

FoxO signaling pathway

KEGG

hsa04110

Cell cycle

KEGG

hsa04115

p53 signaling pathway

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04630

Jak-STAT signaling pathway

KEGG

hsa04921

Oxytocin signaling pathway

KEGG

hsa05160

Hepatitis C

KEGG

hsa05161

Hepatitis B

KEGG

hsa05166

HTLV-I infection

KEGG

hsa05169

Epstein-Barr virus infection

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05202

Transcriptional misregulation in cancer

KEGG

hsa05203

Viral carcinogenesis

KEGG

hsa05205

Proteoglycans in cancer

KEGG

hsa05206

MicroRNAs in cancer

KEGG

hsa05214

Glioma

KEGG

hsa05215

Prostate cancer

KEGG

hsa05218

Melanoma

KEGG

hsa05219

Bladder cancer

KEGG

hsa05220

Chronic myeloid leukemia

KEGG

hsa05224

Breast cancer

KEGG

WP3596

miR-517 relationship with ARCN1 and USP1

WikiPathways

WP707

DNA Damage Response

WikiPathways

WP3941

Oxidative Damage

WikiPathways

WP1742

TP53 Network

WikiPathways

WP1545

miRNAs involved in DNA damage response

WikiPathways

WP2572

Primary Focal Segmental Glomerulosclerosis FSGS

WikiPathways

WP3646

Hepatitis C and Hepatocellular Carcinoma

WikiPathways

WP366

TGF-beta Signaling Pathway

WikiPathways

WP2516

ATM Signaling Pathway

WikiPathways

WP3611

Photodynamic therapy-induced AP-1 survival signaling.

WikiPathways

WP3672

LncRNA-mediated mechanisms of therapeutic resistance

WikiPathways

WP710

DNA Damage Response (only ATM dependent)

WikiPathways

WP236

Adipogenesis

WikiPathways

WP2828

Bladder Cancer

WikiPathways

WP1530

miRNA Regulation of DNA Damage Response

WikiPathways

WP61

Notch Signaling Pathway

WikiPathways

WP615

Senescence and Autophagy in Cancer

WikiPathways

WP45

G1 to S cell cycle control

WikiPathways

WP1971

Integrated Cancer Pathway

WikiPathways

WP1403

AMP-activated Protein Kinase (AMPK) Signaling

WikiPathways

WP2261

Signaling Pathways in Glioblastoma

WikiPathways

WP3680

Association Between Physico-Chemical Features and Toxicity Associated Pathways

WikiPathways

WP179

Cell Cycle

WikiPathways

WP2586

Aryl Hydrocarbon Receptor

WikiPathways

WP2446

Retinoblastoma (RB) in Cancer

WikiPathways

WP2864

Apoptosis-related network due to altered Notch3 in ovarian cancer

WikiPathways

WP138

Androgen receptor signaling pathway

WikiPathways

WP673

ErbB Signaling Pathway

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_atmPathway

ATM Signaling Pathway

BioCarta

h_g2Pathway

Cell Cycle: G2/M Checkpoint

BioCarta

h_g1Pathway

Cell Cycle: G1/S Check Point

BioCarta

h_cellcyclePathway

Cyclins and Cell Cycle Regulation

BioCarta

h_calcineurinPathway

Effects of calcineurin in Keratinocyte Differentiation

BioCarta

h_eponfkbPathway

Erythropoietin mediated neuroprotection through NF-kB

BioCarta

h_p53hypoxiaPathway

Hypoxia and p53 in the Cardiovascular system

BioCarta

h_RacCycDPathway

Influence of Ras and Rho proteins on G1 to S Transition

BioCarta

h_p53Pathway

p53 Signaling Pathway

BioCarta

UMLS CUI UMLS Term

C0005695

Bladder Neoplasm

C0007138

Carcinoma, Transitional Cell

C0009375

Colonic Neoplasms

C0019693

HIV Infections

C0021841

Intestinal Neoplasms

C0022658

Kidney Diseases

C0024121

Lung Neoplasms

C0025267

Multiple Endocrine Neoplasia Type 1

C0030354

Papilloma

C0033578

Prostatic Neoplasms

C0035126

Reperfusion Injury

C0038356

Stomach Neoplasms

C0238288

Muscular Dystrophy, Facioscapulohumeral

Tissue Cell Type

bronchus

respiratory epithelial cells

cervix, uterine

squamous epithelial cells

placenta

trophoblastic cells

testis

Leydig cells

vagina

squamous epithelial cells

Database Name

DisGeNET

Pubmed ID Author Year Title

15308691

Jansen et al.

2004

Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

PAK3

5063

O75914

0.00

PSMC5

5705

P62195

0.49

CDKN1A

1026

P38936

0.52

CSNK2A1

1457

P68400

0.52

FOXO1

2308

Q12778

0.52

HIST1H1B

3009

P16401

0.52

APP

351

P05067

0.56

CDC42

998

P60953

0.56

HDAC2

3066

Q92769

0.56

MCM7

4176

P33993

0.56

NOV

4856

P48745

0.56

HDAC4

9759

P56524

0.56

HDAC6

10013

Q9UBN7

0.56

CDKN1B

1027

P46527

0.62

A1BG

1

P04217

0.63

A2M

2

P01023

0.63

ABR

29

Q12979

0.63

ACTB

60

P60709

0.63

ALAS1

211

P13196

0.63

ANGPT2

285

O15123

0.63

APLP1

333

P51693

0.63

ATP5B

506

P06576

0.63

ATP6V1A

523

P38606

0.63

CAMK2D

817

Q13557

0.63

CENPB

1059

P07199

0.63

CHGB

1114

P05060

0.63

CKS1B

1163

P61024

0.63

CKS2

1164

P33552

0.63

COL4A5

1287

P29400

0.63

CTSB

1508

P07858

0.63

DYNC1I1

1780

O14576

0.63

EEF1A1

1915

P68104

0.63

MARK2

2011

Q7KZI7

0.63

EXT2

2132

Q93063

0.63

F13A1

2162

P00488

0.63

FGB

2244

P02675

0.63

GDF9

2661

O60383

0.63

GNB2

2783

P62879

0.63

HADHB

3032

P55084

0.63

ZBTB48

3104

P10074

0.63

HNRNPA2B1

3181

P22626

0.63

HOXD8

3234

P13378

0.63

HSPA1A

3303

P0DMV8

0.63

HSPA1B

3304

P0DMV9

0.63

HSPA2

3306

P54652

0.63

HSPA5

3309

P11021

0.63

HSPA8

3312

P11142

0.63

HSPA9

3313

P38646

0.63

SP110

3431

Q9HB58

0.63

JUN

3725

P05412

0.63

KRT31

3881

Q15323

0.63

SMAD3

4088

P84022

0.63

ATXN3

4287

P54252

0.63

MSH2

4436

P43246

0.63

NCL

4691

P19338

0.63

NFE2L2

4780

Q16236

0.63

NGFR

4804

P08138

0.63

PDHB

5162

P11177

0.63

PHKA1

5255

P46020

0.63

PHKG2

5261

P15735

0.63

PKM

5315

P14618

0.63

QARS

5859

P47897

0.63

RAB1A

5861

P62820

0.63

RBBP4

5928

Q09028

0.63

RBL2

5934

Q08999

0.63

RPS2

6187

P15880

0.63

RPS4X

6191

P62701

0.63

RPS9

6203

P46781

0.63

RPS16

6217

P62249

0.63

RPS25

6230

P62851

0.63

S100A8

6279

P05109

0.63

SBF1

6305

O95248

0.63

SUMO3

6612

P55854

0.63

SNTB2

6645

Q13425

0.63

SUPT6H

6830

Q7KZ85

0.63

TCF4

6925

P15884

0.63

TLE1

7088

Q04724

0.63

TMSB4X

7114

P62328

0.63

CLEC3B

7123

P05452

0.63

TRAF1

7185

Q13077

0.63

UBC

7316

P0CG48

0.63

UBE2D1

7321

P51668

0.63

USP4

7375

Q13107

0.63

NR1H2

7376

P55055

0.63

VIM

7431

P08670

0.63

ZNF135

7694

P52742

0.63

ZBTB16

7704

Q05516

0.63

MOGS

7841

Q13724

0.63

PDHX

8050

O00330

0.63

USP11

8237

P51784

0.63

BRAP

8315

Q7Z569

0.63

SLC25A11

8402

Q02978

0.63

IRS4

8471

O14654

0.63

PPFIBP1

8496

Q86W92

0.63

PPFIA1

8500

Q13136

0.63

IKBKG

8517

Q9Y6K9

0.63

EIF4EBP3

8637

O60516

0.63

KAT2B

8850

Q92831

0.63

UNC119

9094

Q13432

0.63

EFTUD2

9343

Q15029

0.63

CPNE6

9362

O95741

0.63

PDE4DIP

9659

Q5VU43

0.63

CLINT1

9685

Q14677

0.63

PUM1

9698

Q14671

0.63

KMT2B

9757

Q9UMN6

0.63

SETDB1

9869

Q15047

0.63

TBC1D4

9882

O60343

0.63

LRPPRC

10128

P42704

0.63

CCNO

10309

P22674

0.63

TUBB3

10381

Q13509

0.63

RACK1

10399

P63244

0.63

DEAF1

10522

O75398

0.63

CCT7

10574

Q99832

0.63

PRPF8

10594

Q6P2Q9

0.63

NPRL2

10641

Q8WTW4

0.63

IGF2BP1

10642

Q9NZI8

0.63

GNB5

10681

O14775

0.63

RAI1

10743

Q7Z5J4

0.63

COPS6

10980

Q7L5N1

0.63

FAF1

11124

Q9UNN5

0.63

CELF3

11189

Q5SZQ8

0.63

RPL35

11224

P42766

0.63

IKZF3

22806

Q9UKT9

0.63

PUF60

22827

Q9UHX1

0.63

HMGXB3

22993

Q12766

0.63

FBXO21

23014

O94952

0.63

SNRNP200

23020

O75643

0.63

TTLL5

23093

Q6EMB2

0.63

UBR4

23352

Q5T4S7

0.63

DDAH2

23564

O95865

0.63

ANKRD17

26057

O75179

0.63

GIGYF2

26058

Q6Y7W6

0.63

TRMT2A

27037

Q8IZ69

0.63

TAF5L

27097

O75529

0.63

NMRK2

27231

Q9NPI5

0.63

NRBP1

29959

Q9UHY1

0.63

MED31

51003

Q9Y3C7

0.63

SDF4

51150

Q9BRK5

0.63

UBR5

51366

O95071

0.63

CSAD

51380

Q9Y600

0.63

ACTL6B

51412

O94805

0.63

GET4

51608

Q7L5D6

0.63

INPP5K

51763

Q9BT40

0.63

CPVL

54504

Q9H3G5

0.63

YTHDF1

54915

Q9BYJ9

0.63

C1orf123

54987

Q9NWV4

0.63

OTUB1

55611

Q96FW1

0.63

LRIF1

55791

Q5T3J3

0.63

TRIM54

57159

Q9BYV2

0.63

WIZ

58525

O95785

0.63

NTN4

59277

Q9HB63

0.63

CRELD2

79174

Q6UXH1

0.63

HDAC11

79885

Q96DB2

0.63

CEP290

80184

O15078

0.63

ADAMTS10

81794

Q9H324

0.63

EPPK1

83481

P58107

0.63

RBM48

84060

Q5RL73

0.63

ING5

84289

Q8WYH8

0.63

FBN3

84467

Q75N90

0.63

WDR73

84942

Q6P4I2

0.63

RAVER1

125950

Q8IY67

0.63

KLHL23

151230

Q8NBE8

0.63

AMOT

154796

Q4VCS5

0.63

SPRED1

161742

Q7Z699

0.63

ZNF431

170959

Q8TF32

0.63

CRTC2

200186

Q53ET0

0.63

TUBB

203068

P07437

0.63

CPNE2

221184

Q96FN4

0.63

TUBB2B

347733

Q9BVA1

0.63

EP300

2033

Q09472

0.68

GAPDH

2597

P04406

0.68

YWHAQ

10971

P27348

0.68

NPM1

4869

P06748

0.70

SS18

6760

Q15532

0.72

CUL4A

8451

Q13619

0.72

CDK5R1

8851

Q15078

0.72

RUSC2

9853

Q8N2Y8

0.72

OPTN

10133

Q96CV9

0.72

MAP3K5

4217

Q99683

0.73

BAG6

7917

P46379

0.73

CCDC85B

11007

Q15834

0.73

NABP2

79035

Q9BQ15

0.73

FLAD1

80308

Q8NFF5

0.73

HAUS1

115106

Q96CS2

0.73

TEX11

56159

Q8IYF3

0.74

CREBBP

1387

Q92793

0.75

FKBPL

63943

Q9UIM3

0.75

CEBPA

1050

P49715

0.76

MKRN1

23608

Q9UHC7

0.76

UBB

7314

P0CG47

0.77

CDC45

8318

O75419

0.80

GMNN

51053

O75496

0.80

HDAC1

3065

Q13547

0.81

TUBA1A

7846

Q71U36

0.82

DOCK7

85440

Q96N67

0.82

DDB1

100290337

Q16531

0.83

CSNK2B

1460

P67870

0.85

STAT3

6774

P40763

0.85

MDM2

4193

Q00987

0.87

CCND2

894

P30279

0.89

CDK14

5218

O94921

0.89

DTL

51514

Q9NZJ0

0.89

CDK7

1022

P50613

0.00

AKT3

10000

Q9Y243

0.00

E2F1

1869

Q01094

0.52

SMAD4

4089

Q13485

0.52

GADD45B

4616

O75293

0.52

LATS2

26524

Q9NRM7

0.52

DAPK3

1613

O43293

0.58

BAD

572

Q92934

0.63

VPS51

738

Q9UID3

0.63

GCKR

2646

Q14397

0.63

HNRNPK

3190

P61978

0.63

HPD

3242

P32754

0.63

HSP90AA1

3320

P07900

0.63

MGMT

4255

P16455

0.63

POLR2A

5430

P24928

0.63

PSMD2

5708

Q13200

0.63

RPL18

6141

Q07020

0.63

TXN

7295

P10599

0.63

VCP

7415

P55072

0.63

VDR

7421

P11473

0.63

TRRAP

8295

Q9Y4A5

0.63

CUL1

8454

Q13616

0.63

NCOR1

9611

O75376

0.63

NCOR2

9612

Q9Y618

0.63

TNIP1

10318

Q15025

0.63

CXCL13

10563

O43927

0.63

TXNDC11

51061

Q6PKC3

0.63

TRIM39

56658

Q9HCM9

0.63

TNIP2

79155

Q8NFZ5

0.63

NKD2

85409

Q969F2

0.63

FBXO32

114907

Q969P5

0.63

RNF126

55658

Q9BV68

0.65

AKT2

208

P31751

0.68

CASP3

836

P42574

0.69

RB1

5925

P06400

0.70

CDC7

8317

O00311

0.70

CCNB2

9133

O95067

0.70

RNF144B

255488

Q7Z419

0.71

CDC27

996

P30260

0.72

CHEK1

1111

O14757

0.72

SIPA1

6494

Q96FS4

0.72

PSME3

10197

P61289

0.72

POLD2

5425

P49005

0.73

SKP1

6500

P63208

0.75

HERC5

51191

Q9UII4

0.75

AKT1

207

P31749

0.77

MAPK8

5599

P45983

0.77

CIZ1

25792

Q9ULV3

0.77

MDM4

4194

O15151

0.78

PIM1

5292

P11309

0.78

ESR1

2099

P03372

0.79

CDC5L

988

Q99459

0.80

MCM10

55388

Q7L590

0.80

CDC6

990

Q99741

0.81

CDC20

991

Q12834

0.82

CDK3

1018

Q00526

0.84

CDK6

1021

Q00534

0.86

CDK1

983

P06493

0.87

SET

6418

Q01105

0.87

CCNA1

8900

P78396

0.87

SKP2

6502

Q13309

0.88

TK1

7083

P04183

0.88

TP53

7157

P04637

0.88

CCNE2

9134

O96020

0.88

PARP1

142

P09874

0.89

CCNB1

891

P14635

0.89

CDK5

1020

Q00535

0.89

PSMA3

5684

P25788

0.89

BCCIP

56647

Q9P287

0.89

CCNA2

890

P20248

0.90

CCND3

896

P30281

0.90

CCNE1

898

P24864

0.90

GADD45A

1647

P24522

0.90

PCNA

5111

P12004

0.90

TSG101

7251

Q99816

0.95

CDK4

1019

P11802

0.96

GADD45G

10912

O95257

0.96

CCND1

595

P24385

0.97

CDK2

1017

P24941

0.97