Gene Symbol | CDKN1A |
Entrez ID | 1026 |
Uniprot ID | P38936 |
Description | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
Chromosomal Location | chr6: 36,676,460-36,687,339 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000079 |
regulation of cyclin-dependent protein serine/threonine kinase activity |
Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
TAS |
BP |
GO:0000082 |
G1/S transition of mitotic cell cycle |
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
IDA|TAS |
BP |
GO:0000086 |
G2/M transition of mitotic cell cycle |
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
IMP |
BP |
GO:0006974 |
cellular response to DNA damage stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
IMP |
BP |
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. |
IDA|TAS |
BP |
GO:0007050 |
cell cycle arrest |
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). |
IDA|IMP |
BP |
GO:0007265 |
Ras protein signal transduction |
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
IEP |
BP |
GO:0008285 |
negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
IDA|IMP |
BP |
GO:0009636 |
response to toxic substance |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
IEA |
BP |
GO:0010165 |
response to X-ray |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). |
IEA |
BP |
GO:0010243 |
response to organonitrogen compound |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. |
IEA |
BP |
GO:0010629 |
negative regulation of gene expression |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IEA |
BP |
GO:0030308 |
negative regulation of cell growth |
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
IDA |
BP |
GO:0030890 |
positive regulation of B cell proliferation |
Any process that activates or increases the rate or extent of B cell proliferation. |
IEA |
BP |
GO:0031100 |
animal organ regeneration |
The regrowth of a lost or destroyed animal organ. |
IEA |
BP |
GO:0031668 |
cellular response to extracellular stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. |
IMP |
BP |
GO:0033158 |
regulation of protein import into nucleus, translocation |
Any process that modulates the vectorial transfer of a protein from the cytoplasm into the nucleus, across the nuclear membrane. |
IEA |
BP |
GO:0034198 |
cellular response to amino acid starvation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. |
IMP |
BP |
GO:0034605 |
cellular response to heat |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
IEA |
BP |
GO:0042326 |
negative regulation of phosphorylation |
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule. |
IDA |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. |
IEA |
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IEA |
BP |
GO:0043068 |
positive regulation of programmed cell death |
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. |
IEA |
BP |
GO:0045736 |
negative regulation of cyclin-dependent protein serine/threonine kinase activity |
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
IEA |
BP |
GO:0045860 |
positive regulation of protein kinase activity |
Any process that activates or increases the frequency, rate or extent of protein kinase activity. |
IDA |
BP |
GO:0046685 |
response to arsenic-containing substance |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. |
IEA |
BP |
GO:0048146 |
positive regulation of fibroblast proliferation |
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells. |
IMP |
BP |
GO:0050821 |
protein stabilization |
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
TAS |
BP |
GO:0051412 |
response to corticosterone |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. |
IEA |
BP |
GO:0055093 |
response to hyperoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. |
IEA |
BP |
GO:0060574 |
intestinal epithelial cell maturation |
The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. |
IEA |
BP |
GO:0071479 |
cellular response to ionizing radiation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. |
IMP |
BP |
GO:0071493 |
cellular response to UV-B |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. |
ISS |
BP |
GO:0071850 |
mitotic cell cycle arrest |
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M). |
IEA |
BP |
GO:0090398 |
cellular senescence |
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. |
IMP |
BP |
GO:0090399 |
replicative senescence |
A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. |
IEA |
BP |
GO:0090400 |
stress-induced premature senescence |
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. |
TAS |
BP |
GO:0097193 |
intrinsic apoptotic signaling pathway |
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). |
TAS |
BP |
GO:1904031 |
positive regulation of cyclin-dependent protein kinase activity |
Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. |
IEA |
BP |
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle. |
IGI |
BP |
GO:2000278 |
regulation of DNA biosynthetic process |
Any process that modulates the frequency, rate or extent of DNA biosynthetic process. |
IEA |
BP |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process. |
IMP |
CC |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0043234 |
protein complex |
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. |
IDA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IEA |
CC |
GO:0070557 |
PCNA-p21 complex |
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. |
IDA |
MF |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019912 |
cyclin-dependent protein kinase activating kinase activity |
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). |
IDA |
MF |
GO:0030332 |
cyclin binding |
Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. |
IEA |
MF |
GO:0031625 |
ubiquitin protein ligase binding |
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
IPI |
MF |
GO:0032403 |
protein complex binding |
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IEA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
Domain ID | Description |
---|---|
IPR003175 |
Cyclin-dependent kinase inhibitor |
IPR029841 |
Cyclin-dependent kinase inhibitor 1, vertebrate |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa01522 |
Endocrine resistance |
KEGG |
hsa01524 |
Platinum drug resistance |
KEGG |
hsa04012 |
ErbB signaling pathway |
KEGG |
hsa04066 |
HIF-1 signaling pathway |
KEGG |
hsa04068 |
FoxO signaling pathway |
KEGG |
hsa04110 |
Cell cycle |
KEGG |
hsa04115 |
p53 signaling pathway |
KEGG |
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
hsa04921 |
Oxytocin signaling pathway |
KEGG |
hsa05160 |
Hepatitis C |
KEGG |
hsa05161 |
Hepatitis B |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
hsa05169 |
Epstein-Barr virus infection |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05202 |
Transcriptional misregulation in cancer |
KEGG |
hsa05203 |
Viral carcinogenesis |
KEGG |
hsa05205 |
Proteoglycans in cancer |
KEGG |
hsa05206 |
MicroRNAs in cancer |
KEGG |
hsa05214 |
Glioma |
KEGG |
hsa05215 |
Prostate cancer |
KEGG |
hsa05218 |
Melanoma |
KEGG |
hsa05219 |
Bladder cancer |
KEGG |
hsa05220 |
Chronic myeloid leukemia |
KEGG |
hsa05224 |
Breast cancer |
KEGG |
WP3596 |
miR-517 relationship with ARCN1 and USP1 |
WikiPathways |
WP707 |
DNA Damage Response |
WikiPathways |
WP3941 |
Oxidative Damage |
WikiPathways |
WP1742 |
TP53 Network |
WikiPathways |
WP1545 |
miRNAs involved in DNA damage response |
WikiPathways |
WP2572 |
Primary Focal Segmental Glomerulosclerosis FSGS |
WikiPathways |
WP3646 |
Hepatitis C and Hepatocellular Carcinoma |
WikiPathways |
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
WP2516 |
ATM Signaling Pathway |
WikiPathways |
WP3611 |
Photodynamic therapy-induced AP-1 survival signaling. |
WikiPathways |
WP3672 |
LncRNA-mediated mechanisms of therapeutic resistance |
WikiPathways |
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
WP236 |
Adipogenesis |
WikiPathways |
WP2828 |
Bladder Cancer |
WikiPathways |
WP1530 |
miRNA Regulation of DNA Damage Response |
WikiPathways |
WP61 |
Notch Signaling Pathway |
WikiPathways |
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
WP45 |
G1 to S cell cycle control |
WikiPathways |
WP1971 |
Integrated Cancer Pathway |
WikiPathways |
WP1403 |
AMP-activated Protein Kinase (AMPK) Signaling |
WikiPathways |
WP2261 |
Signaling Pathways in Glioblastoma |
WikiPathways |
WP3680 |
Association Between Physico-Chemical Features and Toxicity Associated Pathways |
WikiPathways |
WP179 |
Cell Cycle |
WikiPathways |
WP2586 |
Aryl Hydrocarbon Receptor |
WikiPathways |
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
WP2864 |
Apoptosis-related network due to altered Notch3 in ovarian cancer |
WikiPathways |
WP138 |
Androgen receptor signaling pathway |
WikiPathways |
WP673 |
ErbB Signaling Pathway |
WikiPathways |
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
h_atmPathway |
ATM Signaling Pathway |
BioCarta |
h_g2Pathway |
Cell Cycle: G2/M Checkpoint |
BioCarta |
h_g1Pathway |
Cell Cycle: G1/S Check Point |
BioCarta |
h_cellcyclePathway |
Cyclins and Cell Cycle Regulation |
BioCarta |
h_calcineurinPathway |
Effects of calcineurin in Keratinocyte Differentiation |
BioCarta |
h_eponfkbPathway |
Erythropoietin mediated neuroprotection through NF-kB |
BioCarta |
h_p53hypoxiaPathway |
Hypoxia and p53 in the Cardiovascular system |
BioCarta |
h_RacCycDPathway |
Influence of Ras and Rho proteins on G1 to S Transition |
BioCarta |
h_p53Pathway |
p53 Signaling Pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0005695 |
Bladder Neoplasm |
C0007138 |
Carcinoma, Transitional Cell |
C0009375 |
Colonic Neoplasms |
C0019693 |
HIV Infections |
C0021841 |
Intestinal Neoplasms |
C0022658 |
Kidney Diseases |
C0024121 |
Lung Neoplasms |
C0025267 |
Multiple Endocrine Neoplasia Type 1 |
C0030354 |
Papilloma |
C0033578 |
Prostatic Neoplasms |
C0035126 |
Reperfusion Injury |
C0038356 |
Stomach Neoplasms |
C0238288 |
Muscular Dystrophy, Facioscapulohumeral |
Tissue | Cell Type |
---|---|
bronchus |
respiratory epithelial cells |
cervix, uterine |
squamous epithelial cells |
placenta |
trophoblastic cells |
testis |
Leydig cells |
vagina |
squamous epithelial cells |
Database Name |
---|
DisGeNET |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15308691 |
Jansen et al. |
2004 |
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients |
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
PAK3 |
5063 |
O75914 |
0.00 |
PSMC5 |
5705 |
P62195 |
0.49 |
CDKN1A |
1026 |
P38936 |
0.52 |
CSNK2A1 |
1457 |
P68400 |
0.52 |
FOXO1 |
2308 |
Q12778 |
0.52 |
HIST1H1B |
3009 |
P16401 |
0.52 |
APP |
351 |
P05067 |
0.56 |
CDC42 |
998 |
P60953 |
0.56 |
HDAC2 |
3066 |
Q92769 |
0.56 |
MCM7 |
4176 |
P33993 |
0.56 |
NOV |
4856 |
P48745 |
0.56 |
HDAC4 |
9759 |
P56524 |
0.56 |
HDAC6 |
10013 |
Q9UBN7 |
0.56 |
CDKN1B |
1027 |
P46527 |
0.62 |
A1BG |
1 |
P04217 |
0.63 |
A2M |
2 |
P01023 |
0.63 |
ABR |
29 |
Q12979 |
0.63 |
ACTB |
60 |
P60709 |
0.63 |
ALAS1 |
211 |
P13196 |
0.63 |
ANGPT2 |
285 |
O15123 |
0.63 |
APLP1 |
333 |
P51693 |
0.63 |
ATP5B |
506 |
P06576 |
0.63 |
ATP6V1A |
523 |
P38606 |
0.63 |
CAMK2D |
817 |
Q13557 |
0.63 |
CENPB |
1059 |
P07199 |
0.63 |
CHGB |
1114 |
P05060 |
0.63 |
CKS1B |
1163 |
P61024 |
0.63 |
CKS2 |
1164 |
P33552 |
0.63 |
COL4A5 |
1287 |
P29400 |
0.63 |
CTSB |
1508 |
P07858 |
0.63 |
DYNC1I1 |
1780 |
O14576 |
0.63 |
EEF1A1 |
1915 |
P68104 |
0.63 |
MARK2 |
2011 |
Q7KZI7 |
0.63 |
EXT2 |
2132 |
Q93063 |
0.63 |
F13A1 |
2162 |
P00488 |
0.63 |
FGB |
2244 |
P02675 |
0.63 |
GDF9 |
2661 |
O60383 |
0.63 |
GNB2 |
2783 |
P62879 |
0.63 |
HADHB |
3032 |
P55084 |
0.63 |
ZBTB48 |
3104 |
P10074 |
0.63 |
HNRNPA2B1 |
3181 |
P22626 |
0.63 |
HOXD8 |
3234 |
P13378 |
0.63 |
HSPA1A |
3303 |
P0DMV8 |
0.63 |
HSPA1B |
3304 |
P0DMV9 |
0.63 |
HSPA2 |
3306 |
P54652 |
0.63 |
HSPA5 |
3309 |
P11021 |
0.63 |
HSPA8 |
3312 |
P11142 |
0.63 |
HSPA9 |
3313 |
P38646 |
0.63 |
SP110 |
3431 |
Q9HB58 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
KRT31 |
3881 |
Q15323 |
0.63 |
SMAD3 |
4088 |
P84022 |
0.63 |
ATXN3 |
4287 |
P54252 |
0.63 |
MSH2 |
4436 |
P43246 |
0.63 |
NCL |
4691 |
P19338 |
0.63 |
NFE2L2 |
4780 |
Q16236 |
0.63 |
NGFR |
4804 |
P08138 |
0.63 |
PDHB |
5162 |
P11177 |
0.63 |
PHKA1 |
5255 |
P46020 |
0.63 |
PHKG2 |
5261 |
P15735 |
0.63 |
PKM |
5315 |
P14618 |
0.63 |
QARS |
5859 |
P47897 |
0.63 |
RAB1A |
5861 |
P62820 |
0.63 |
RBBP4 |
5928 |
Q09028 |
0.63 |
RBL2 |
5934 |
Q08999 |
0.63 |
RPS2 |
6187 |
P15880 |
0.63 |
RPS4X |
6191 |
P62701 |
0.63 |
RPS9 |
6203 |
P46781 |
0.63 |
RPS16 |
6217 |
P62249 |
0.63 |
RPS25 |
6230 |
P62851 |
0.63 |
S100A8 |
6279 |
P05109 |
0.63 |
SBF1 |
6305 |
O95248 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
SNTB2 |
6645 |
Q13425 |
0.63 |
SUPT6H |
6830 |
Q7KZ85 |
0.63 |
TCF4 |
6925 |
P15884 |
0.63 |
TLE1 |
7088 |
Q04724 |
0.63 |
TMSB4X |
7114 |
P62328 |
0.63 |
CLEC3B |
7123 |
P05452 |
0.63 |
TRAF1 |
7185 |
Q13077 |
0.63 |
UBC |
7316 |
P0CG48 |
0.63 |
UBE2D1 |
7321 |
P51668 |
0.63 |
USP4 |
7375 |
Q13107 |
0.63 |
NR1H2 |
7376 |
P55055 |
0.63 |
VIM |
7431 |
P08670 |
0.63 |
ZNF135 |
7694 |
P52742 |
0.63 |
ZBTB16 |
7704 |
Q05516 |
0.63 |
MOGS |
7841 |
Q13724 |
0.63 |
PDHX |
8050 |
O00330 |
0.63 |
USP11 |
8237 |
P51784 |
0.63 |
BRAP |
8315 |
Q7Z569 |
0.63 |
SLC25A11 |
8402 |
Q02978 |
0.63 |
IRS4 |
8471 |
O14654 |
0.63 |
PPFIBP1 |
8496 |
Q86W92 |
0.63 |
PPFIA1 |
8500 |
Q13136 |
0.63 |
IKBKG |
8517 |
Q9Y6K9 |
0.63 |
EIF4EBP3 |
8637 |
O60516 |
0.63 |
KAT2B |
8850 |
Q92831 |
0.63 |
UNC119 |
9094 |
Q13432 |
0.63 |
EFTUD2 |
9343 |
Q15029 |
0.63 |
CPNE6 |
9362 |
O95741 |
0.63 |
PDE4DIP |
9659 |
Q5VU43 |
0.63 |
CLINT1 |
9685 |
Q14677 |
0.63 |
PUM1 |
9698 |
Q14671 |
0.63 |
KMT2B |
9757 |
Q9UMN6 |
0.63 |
SETDB1 |
9869 |
Q15047 |
0.63 |
TBC1D4 |
9882 |
O60343 |
0.63 |
LRPPRC |
10128 |
P42704 |
0.63 |
CCNO |
10309 |
P22674 |
0.63 |
TUBB3 |
10381 |
Q13509 |
0.63 |
RACK1 |
10399 |
P63244 |
0.63 |
DEAF1 |
10522 |
O75398 |
0.63 |
CCT7 |
10574 |
Q99832 |
0.63 |
PRPF8 |
10594 |
Q6P2Q9 |
0.63 |
NPRL2 |
10641 |
Q8WTW4 |
0.63 |
IGF2BP1 |
10642 |
Q9NZI8 |
0.63 |
GNB5 |
10681 |
O14775 |
0.63 |
RAI1 |
10743 |
Q7Z5J4 |
0.63 |
COPS6 |
10980 |
Q7L5N1 |
0.63 |
FAF1 |
11124 |
Q9UNN5 |
0.63 |
CELF3 |
11189 |
Q5SZQ8 |
0.63 |
RPL35 |
11224 |
P42766 |
0.63 |
IKZF3 |
22806 |
Q9UKT9 |
0.63 |
PUF60 |
22827 |
Q9UHX1 |
0.63 |
HMGXB3 |
22993 |
Q12766 |
0.63 |
FBXO21 |
23014 |
O94952 |
0.63 |
SNRNP200 |
23020 |
O75643 |
0.63 |
TTLL5 |
23093 |
Q6EMB2 |
0.63 |
UBR4 |
23352 |
Q5T4S7 |
0.63 |
DDAH2 |
23564 |
O95865 |
0.63 |
ANKRD17 |
26057 |
O75179 |
0.63 |
GIGYF2 |
26058 |
Q6Y7W6 |
0.63 |
TRMT2A |
27037 |
Q8IZ69 |
0.63 |
TAF5L |
27097 |
O75529 |
0.63 |
NMRK2 |
27231 |
Q9NPI5 |
0.63 |
NRBP1 |
29959 |
Q9UHY1 |
0.63 |
MED31 |
51003 |
Q9Y3C7 |
0.63 |
SDF4 |
51150 |
Q9BRK5 |
0.63 |
UBR5 |
51366 |
O95071 |
0.63 |
CSAD |
51380 |
Q9Y600 |
0.63 |
ACTL6B |
51412 |
O94805 |
0.63 |
GET4 |
51608 |
Q7L5D6 |
0.63 |
INPP5K |
51763 |
Q9BT40 |
0.63 |
CPVL |
54504 |
Q9H3G5 |
0.63 |
YTHDF1 |
54915 |
Q9BYJ9 |
0.63 |
C1orf123 |
54987 |
Q9NWV4 |
0.63 |
OTUB1 |
55611 |
Q96FW1 |
0.63 |
LRIF1 |
55791 |
Q5T3J3 |
0.63 |
TRIM54 |
57159 |
Q9BYV2 |
0.63 |
WIZ |
58525 |
O95785 |
0.63 |
NTN4 |
59277 |
Q9HB63 |
0.63 |
CRELD2 |
79174 |
Q6UXH1 |
0.63 |
HDAC11 |
79885 |
Q96DB2 |
0.63 |
CEP290 |
80184 |
O15078 |
0.63 |
ADAMTS10 |
81794 |
Q9H324 |
0.63 |
EPPK1 |
83481 |
P58107 |
0.63 |
RBM48 |
84060 |
Q5RL73 |
0.63 |
ING5 |
84289 |
Q8WYH8 |
0.63 |
FBN3 |
84467 |
Q75N90 |
0.63 |
WDR73 |
84942 |
Q6P4I2 |
0.63 |
RAVER1 |
125950 |
Q8IY67 |
0.63 |
KLHL23 |
151230 |
Q8NBE8 |
0.63 |
AMOT |
154796 |
Q4VCS5 |
0.63 |
SPRED1 |
161742 |
Q7Z699 |
0.63 |
ZNF431 |
170959 |
Q8TF32 |
0.63 |
CRTC2 |
200186 |
Q53ET0 |
0.63 |
TUBB |
203068 |
P07437 |
0.63 |
CPNE2 |
221184 |
Q96FN4 |
0.63 |
TUBB2B |
347733 |
Q9BVA1 |
0.63 |
EP300 |
2033 |
Q09472 |
0.68 |
GAPDH |
2597 |
P04406 |
0.68 |
YWHAQ |
10971 |
P27348 |
0.68 |
NPM1 |
4869 |
P06748 |
0.70 |
SS18 |
6760 |
Q15532 |
0.72 |
CUL4A |
8451 |
Q13619 |
0.72 |
CDK5R1 |
8851 |
Q15078 |
0.72 |
RUSC2 |
9853 |
Q8N2Y8 |
0.72 |
OPTN |
10133 |
Q96CV9 |
0.72 |
MAP3K5 |
4217 |
Q99683 |
0.73 |
BAG6 |
7917 |
P46379 |
0.73 |
CCDC85B |
11007 |
Q15834 |
0.73 |
NABP2 |
79035 |
Q9BQ15 |
0.73 |
FLAD1 |
80308 |
Q8NFF5 |
0.73 |
HAUS1 |
115106 |
Q96CS2 |
0.73 |
TEX11 |
56159 |
Q8IYF3 |
0.74 |
CREBBP |
1387 |
Q92793 |
0.75 |
FKBPL |
63943 |
Q9UIM3 |
0.75 |
CEBPA |
1050 |
P49715 |
0.76 |
MKRN1 |
23608 |
Q9UHC7 |
0.76 |
UBB |
7314 |
P0CG47 |
0.77 |
CDC45 |
8318 |
O75419 |
0.80 |
GMNN |
51053 |
O75496 |
0.80 |
HDAC1 |
3065 |
Q13547 |
0.81 |
TUBA1A |
7846 |
Q71U36 |
0.82 |
DOCK7 |
85440 |
Q96N67 |
0.82 |
DDB1 |
100290337 |
Q16531 |
0.83 |
CSNK2B |
1460 |
P67870 |
0.85 |
STAT3 |
6774 |
P40763 |
0.85 |
MDM2 |
4193 |
Q00987 |
0.87 |
CCND2 |
894 |
P30279 |
0.89 |
CDK14 |
5218 |
O94921 |
0.89 |
DTL |
51514 |
Q9NZJ0 |
0.89 |
CDK7 |
1022 |
P50613 |
0.00 |
AKT3 |
10000 |
Q9Y243 |
0.00 |
E2F1 |
1869 |
Q01094 |
0.52 |
SMAD4 |
4089 |
Q13485 |
0.52 |
GADD45B |
4616 |
O75293 |
0.52 |
LATS2 |
26524 |
Q9NRM7 |
0.52 |
DAPK3 |
1613 |
O43293 |
0.58 |
BAD |
572 |
Q92934 |
0.63 |
VPS51 |
738 |
Q9UID3 |
0.63 |
GCKR |
2646 |
Q14397 |
0.63 |
HNRNPK |
3190 |
P61978 |
0.63 |
HPD |
3242 |
P32754 |
0.63 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
MGMT |
4255 |
P16455 |
0.63 |
POLR2A |
5430 |
P24928 |
0.63 |
PSMD2 |
5708 |
Q13200 |
0.63 |
RPL18 |
6141 |
Q07020 |
0.63 |
TXN |
7295 |
P10599 |
0.63 |
VCP |
7415 |
P55072 |
0.63 |
VDR |
7421 |
P11473 |
0.63 |
TRRAP |
8295 |
Q9Y4A5 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
NCOR1 |
9611 |
O75376 |
0.63 |
NCOR2 |
9612 |
Q9Y618 |
0.63 |
TNIP1 |
10318 |
Q15025 |
0.63 |
CXCL13 |
10563 |
O43927 |
0.63 |
TXNDC11 |
51061 |
Q6PKC3 |
0.63 |
TRIM39 |
56658 |
Q9HCM9 |
0.63 |
TNIP2 |
79155 |
Q8NFZ5 |
0.63 |
NKD2 |
85409 |
Q969F2 |
0.63 |
FBXO32 |
114907 |
Q969P5 |
0.63 |
RNF126 |
55658 |
Q9BV68 |
0.65 |
AKT2 |
208 |
P31751 |
0.68 |
CASP3 |
836 |
P42574 |
0.69 |
RB1 |
5925 |
P06400 |
0.70 |
CDC7 |
8317 |
O00311 |
0.70 |
CCNB2 |
9133 |
O95067 |
0.70 |
RNF144B |
255488 |
Q7Z419 |
0.71 |
CDC27 |
996 |
P30260 |
0.72 |
CHEK1 |
1111 |
O14757 |
0.72 |
SIPA1 |
6494 |
Q96FS4 |
0.72 |
PSME3 |
10197 |
P61289 |
0.72 |
POLD2 |
5425 |
P49005 |
0.73 |
SKP1 |
6500 |
P63208 |
0.75 |
HERC5 |
51191 |
Q9UII4 |
0.75 |
AKT1 |
207 |
P31749 |
0.77 |
MAPK8 |
5599 |
P45983 |
0.77 |
CIZ1 |
25792 |
Q9ULV3 |
0.77 |
MDM4 |
4194 |
O15151 |
0.78 |
PIM1 |
5292 |
P11309 |
0.78 |
ESR1 |
2099 |
P03372 |
0.79 |
CDC5L |
988 |
Q99459 |
0.80 |
MCM10 |
55388 |
Q7L590 |
0.80 |
CDC6 |
990 |
Q99741 |
0.81 |
CDC20 |
991 |
Q12834 |
0.82 |
CDK3 |
1018 |
Q00526 |
0.84 |
CDK6 |
1021 |
Q00534 |
0.86 |
CDK1 |
983 |
P06493 |
0.87 |
SET |
6418 |
Q01105 |
0.87 |
CCNA1 |
8900 |
P78396 |
0.87 |
SKP2 |
6502 |
Q13309 |
0.88 |
TK1 |
7083 |
P04183 |
0.88 |
TP53 |
7157 |
P04637 |
0.88 |
CCNE2 |
9134 |
O96020 |
0.88 |
PARP1 |
142 |
P09874 |
0.89 |
CCNB1 |
891 |
P14635 |
0.89 |
CDK5 |
1020 |
Q00535 |
0.89 |
PSMA3 |
5684 |
P25788 |
0.89 |
BCCIP |
56647 |
Q9P287 |
0.89 |
CCNA2 |
890 |
P20248 |
0.90 |
CCND3 |
896 |
P30281 |
0.90 |
CCNE1 |
898 |
P24864 |
0.90 |
GADD45A |
1647 |
P24522 |
0.90 |
PCNA |
5111 |
P12004 |
0.90 |
TSG101 |
7251 |
Q99816 |
0.95 |
CDK4 |
1019 |
P11802 |
0.96 |
GADD45G |
10912 |
O95257 |
0.96 |
CCND1 |
595 |
P24385 |
0.97 |
CDK2 |
1017 |
P24941 |
0.97 |