| Gene Symbol | DSTN |
| Entrez ID | 11034 |
| Uniprot ID | P60981 |
| Description | destrin (actin depolymerizing factor) |
| Chromosomal Location | chr20: 17,569,863-17,609,919 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0008154 |
actin polymerization or depolymerization |
Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. |
TAS |
|
BP |
GO:0030042 |
actin filament depolymerization |
Disassembly of actin filaments by the removal of actin monomers from a filament. |
IDA |
|
BP |
GO:0030836 |
positive regulation of actin filament depolymerization |
Any process that activates or increases the frequency, rate or extent of actin depolymerization. |
IEA |
|
BP |
GO:0051014 |
actin filament severing |
The process in which an actin filament is broken down into smaller filaments. |
IEA |
|
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
TAS |
|
CC |
GO:0030864 |
cortical actin cytoskeleton |
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0051015 |
actin filament binding |
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR002108 |
Actin-depolymerising factor homology domain |
|
IPR017904 |
ADF/Cofilin |
|
IPR029006 |
ADF-H/Gelsolin-like domain |
|
IPR029924 |
Destrin |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP138 |
Androgen receptor signaling pathway |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
cerebellum |
Purkinje cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ABAT |
18 |
P80404 |
0.49 |
|
ACTA1 |
58 |
P68133 |
0.49 |
|
HSPE1 |
3336 |
P61604 |
0.49 |
|
IGFBP7 |
3490 |
Q16270 |
0.49 |
|
ITGB1 |
3688 |
P05556 |
0.49 |
|
LDHA |
3939 |
P00338 |
0.49 |
|
LDHB |
3945 |
P07195 |
0.49 |
|
MCM7 |
4176 |
P33993 |
0.49 |
|
MIF |
4282 |
P14174 |
0.49 |
|
MYH11 |
4629 |
P35749 |
0.49 |
|
PCBP1 |
5093 |
Q15365 |
0.49 |
|
PSMD9 |
5715 |
O00233 |
0.49 |
|
PTMA |
5757 |
P06454 |
0.49 |
|
PTMS |
5763 |
P20962 |
0.49 |
|
PEX19 |
5824 |
P40855 |
0.49 |
|
PXN |
5829 |
P49023 |
0.49 |
|
RNH1 |
6050 |
P13489 |
0.49 |
|
S100A9 |
6280 |
P06702 |
0.49 |
|
SRSF2 |
6427 |
Q01130 |
0.49 |
|
SGTA |
6449 |
O43765 |
0.49 |
|
ITSN1 |
6453 |
Q15811 |
0.49 |
|
SP100 |
6672 |
P23497 |
0.49 |
|
SPR |
6697 |
P35270 |
0.49 |
|
STAT6 |
6778 |
P42226 |
0.49 |
|
TPI1 |
7167 |
P60174 |
0.49 |
|
TPM2 |
7169 |
P07951 |
0.49 |
|
TSTA3 |
7264 |
Q13630 |
0.49 |
|
TTC1 |
7265 |
Q99614 |
0.49 |
|
UBE2B |
7320 |
P63146 |
0.49 |
|
VCP |
7415 |
P55072 |
0.49 |
|
ALDH4A1 |
8659 |
P30038 |
0.49 |
|
LIMD1 |
8994 |
Q9UGP4 |
0.49 |
|
UBA3 |
9039 |
Q8TBC4 |
0.49 |
|
NMI |
9111 |
Q13287 |
0.49 |
|
PUM1 |
9698 |
Q14671 |
0.49 |
|
PIEZO1 |
9780 |
Q92508 |
0.49 |
|
DPP3 |
10072 |
Q9NY33 |
0.49 |
|
LAMTOR5 |
10542 |
O43504 |
0.49 |
|
DNPH1 |
10591 |
O43598 |
0.49 |
|
PDLIM5 |
10611 |
Q96HC4 |
0.49 |
|
SEC24A |
10802 |
O95486 |
0.49 |
|
STMN2 |
11075 |
Q93045 |
0.49 |
|
SEC23IP |
11196 |
Q9Y6Y8 |
0.49 |
|
PALLD |
23022 |
Q8WX93 |
0.49 |
|
HIBCH |
26275 |
Q6NVY1 |
0.49 |
|
HSPB8 |
26353 |
Q9UJY1 |
0.49 |
|
MEMO1 |
51072 |
Q9Y316 |
0.49 |
|
POMP |
51371 |
Q9Y244 |
0.49 |
|
CROT |
54677 |
Q9UKG9 |
0.49 |
|
DNAJB12 |
54788 |
Q9NXW2 |
0.49 |
|
OTUB1 |
55611 |
Q96FW1 |
0.49 |
|
RNF114 |
55905 |
Q9Y508 |
0.49 |
|
C12orf10 |
60314 |
Q9HB07 |
0.49 |
|
URM1 |
81605 |
Q9BTM9 |
0.49 |
|
SLIRP |
81892 |
Q9GZT3 |
0.49 |
|
TUBA1C |
84790 |
Q9BQE3 |
0.49 |
|
ZFYVE19 |
84936 |
Q96K21 |
0.49 |
|
UNK |
85451 |
Q9C0B0 |
0.49 |
|
OTULIN |
90268 |
Q96BN8 |
0.49 |
|
MCFD2 |
90411 |
Q8NI22 |
0.49 |
|
MDP1 |
145553 |
Q86V88 |
0.49 |
|
TOM1L2 |
146691 |
Q6ZVM7 |
0.49 |
|
PPP4R2 |
151987 |
Q9NY27 |
0.49 |
|
LDHAL6A |
160287 |
Q6ZMR3 |
0.49 |
|
NME2 |
4831 |
P22392 |
0.56 |
|
PRDX5 |
25824 |
P30044 |
0.56 |
|
SHBG |
6462 |
P04278 |
0.63 |
|
SMAD9 |
4093 |
O15198 |
0.73 |
|
ACTG1 |
71 |
P63261 |
0.92 |
|
CRIP1 |
1396 |
P50238 |
0.49 |
|
ST13 |
6767 |
P50502 |
0.49 |
|
PIR |
8544 |
O00625 |
0.49 |
|
KYNU |
8942 |
Q16719 |
0.49 |
|
HTRA2 |
27429 |
O43464 |
0.49 |
|
TESK2 |
10420 |
Q96S53 |
0.52 |
|
SOD1 |
6647 |
P00441 |
0.56 |
|
WDR1 |
9948 |
O75083 |
0.56 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
CFL2 |
1073 |
Q9Y281 |
0.63 |
|
GH1 |
2688 |
P01241 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
TAX1BP1 |
8887 |
Q86VP1 |
0.63 |
|
ISG15 |
9636 |
P05161 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
TNIK |
23043 |
Q9UKE5 |
0.63 |
|
PINX1 |
54984 |
Q96BK5 |
0.63 |
|
SSH1 |
54434 |
Q8WYL5 |
0.65 |
|
MCM2 |
4171 |
P49736 |
0.70 |
|
MYH9 |
4627 |
P35579 |
0.72 |
|
MYO1C |
4641 |
O00159 |
0.72 |
|
PPP1CB |
5500 |
P62140 |
0.72 |
|
RRBP1 |
6238 |
Q9P2E9 |
0.72 |
|
MYO18A |
399687 |
Q92614 |
0.72 |
|
ACTB |
60 |
P60709 |
0.73 |