| Gene Symbol | CBX1 |
| Entrez ID | 10951 |
| Uniprot ID | P83916 |
| Description | chromobox 1 |
| Chromosomal Location | chr17: 48,070,052-48,101,521 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
IEA |
|
CC |
GO:0000775 |
chromosome, centromeric region |
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. |
IDA |
|
CC |
GO:0000784 |
nuclear chromosome, telomeric region |
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. |
IDA |
|
CC |
GO:0000785 |
chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
IDA |
|
CC |
GO:0001939 |
female pronucleus |
The pronucleus originating from the ovum that is being fertilized. |
IEA |
|
CC |
GO:0001940 |
male pronucleus |
The pronucleus originating from the spermatozoa that was involved in fertilization. |
IEA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005720 |
nuclear heterochromatin |
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin. |
TAS |
|
CC |
GO:0005721 |
pericentric heterochromatin |
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. |
IEA |
|
CC |
GO:0005819 |
spindle |
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
IDA |
|
CC |
GO:0010369 |
chromocenter |
A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure. |
IEA |
|
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
|
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IEA |
|
MF |
GO:1990226 |
histone methyltransferase binding |
Interacting selectively and non-covalently with a histone methyltransferase enzyme. |
IPI |
| Domain ID | Description |
|---|---|
|
IPR000953 |
Chromo/chromo shadow domain |
|
IPR008251 |
Chromo shadow domain |
|
IPR016197 |
Chromo domain-like |
|
IPR017984 |
Chromo domain subgroup |
|
IPR023779 |
Chromo domain, conserved site |
|
IPR023780 |
Chromo domain |
| UMLS CUI | UMLS Term |
|---|---|
|
C0033578 |
Prostatic Neoplasms |
| Tissue | Cell Type |
|---|---|
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
glial cells |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
peripheral nerve |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
KLF11 |
8462 |
O14901 |
0.56 |
|
TRIM24 |
8805 |
O15164 |
0.59 |
|
ACP2 |
53 |
P11117 |
0.63 |
|
AGL |
178 |
P35573 |
0.63 |
|
CHD3 |
1107 |
Q12873 |
0.63 |
|
DTNA |
1837 |
Q9Y4J8 |
0.63 |
|
FAT1 |
2195 |
Q14517 |
0.63 |
|
HIST1H2AD |
3013 |
P20671 |
0.63 |
|
HIST1H2BB |
3018 |
P33778 |
0.63 |
|
KPNA4 |
3839 |
O00629 |
0.63 |
|
KPNA3 |
3840 |
O00505 |
0.63 |
|
LBR |
3930 |
Q14739 |
0.63 |
|
PCNA |
5111 |
P12004 |
0.63 |
|
PRKACA |
5566 |
P17612 |
0.63 |
|
SMARCA4 |
6597 |
P51532 |
0.63 |
|
VTN |
7448 |
P04004 |
0.63 |
|
CHAF1B |
8208 |
Q13112 |
0.63 |
|
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI |
8339 |
P62807 |
0.63 |
|
EIF5B |
9669 |
O60841 |
0.63 |
|
ZBED4 |
9889 |
O75132 |
0.63 |
|
THRAP3 |
9967 |
Q9Y2W1 |
0.63 |
|
NINL |
22981 |
Q9Y2I6 |
0.63 |
|
ZCCHC11 |
23318 |
Q5TAX3 |
0.63 |
|
ABI3BP |
25890 |
Q7Z7G0 |
0.63 |
|
INTS1 |
26173 |
Q8N201 |
0.63 |
|
ARL5A |
26225 |
Q9Y689 |
0.63 |
|
AHDC1 |
27245 |
Q5TGY3 |
0.63 |
|
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
|
SSH1 |
54434 |
Q8WYL5 |
0.63 |
|
ZNF280D |
54816 |
Q6N043 |
0.63 |
|
RIF1 |
55183 |
Q5UIP0 |
0.63 |
|
LRIF1 |
55791 |
Q5T3J3 |
0.63 |
|
PLEKHH1 |
57475 |
Q9ULM0 |
0.63 |
|
NLN |
57486 |
Q9BYT8 |
0.63 |
|
H2AFV |
94239 |
Q71UI9 |
0.63 |
|
CCDC148 |
130940 |
Q8NFR7 |
0.63 |
|
C2orf69 |
205327 |
Q8N8R5 |
0.63 |
|
FMN1 |
342184 |
Q68DA7 |
0.63 |
|
H2AFB1 |
474382 |
P0C5Y9 |
0.63 |
|
HIST1H2AB; HIST1H2AE |
3012 |
P04908 |
0.63 |
|
XRCC6 |
2547 |
P12956 |
0.72 |
|
MKI67 |
4288 |
P46013 |
0.72 |
|
HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4 |
121504 |
P62805 |
0.72 |
|
PIM1 |
5292 |
P11309 |
0.74 |
|
DNMT3B |
1789 |
Q9UBC3 |
0.75 |
|
NR2F6 |
2063 |
P10588 |
0.75 |
|
DNMT1 |
1786 |
P26358 |
0.76 |
|
DNMT3A |
1788 |
Q9Y6K1 |
0.76 |
|
ADNP2 |
22850 |
Q6IQ32 |
0.76 |
|
BARD1 |
580 |
Q99728 |
0.78 |
|
CHD4 |
1108 |
Q14839 |
0.82 |
|
SUV39H1 |
6839 |
O43463 |
0.85 |
|
ADNP |
23394 |
Q9H2P0 |
0.86 |
|
CHAMP1 |
283489 |
Q96JM3 |
0.87 |
|
CBX3 |
11335 |
Q13185 |
0.90 |
|
CHAF1A |
10036 |
Q13111 |
0.95 |
|
TRIM28 |
10155 |
Q13263 |
0.96 |
|
HIST1H3A |
8350 |
P68431 |
0.97 |
|
CBX1 |
10951 |
P83916 |
0.97 |
|
CBX5 |
23468 |
P45973 |
0.97 |
|
HIST1H1E |
3008 |
P10412 |
0.52 |
|
CDYL |
9425 |
Q9Y232 |
0.55 |
|
BRCA1 |
672 |
P38398 |
0.56 |
|
H3F3A; H3F3B |
3020 |
P84243 |
0.63 |
|
HSPB1 |
3315 |
P04792 |
0.63 |
|
IFI16 |
3428 |
Q16666 |
0.63 |
|
MECP2 |
4204 |
P51608 |
0.63 |
|
MYOD1 |
4654 |
P15172 |
0.63 |
|
PARK2 |
5071 |
O60260 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RPL12 |
6136 |
P30050 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
SP100 |
6672 |
P23497 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
UCHL1 |
7345 |
P09936 |
0.63 |
|
BANF1 |
8815 |
O75531 |
0.63 |
|
CHD1L |
9557 |
Q86WJ1 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
USP39 |
10713 |
Q53GS9 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
NSL1 |
25936 |
Q96IY1 |
0.63 |
|
TRIM33 |
51592 |
Q9UPN9 |
0.63 |
|
TRIM39 |
56658 |
Q9HCM9 |
0.63 |
|
SUV39H2 |
79723 |
Q9H5I1 |
0.63 |
|
ZNF382 |
84911 |
Q96SR6 |
0.63 |
|
PRDM6 |
93166 |
Q9NQX0 |
0.63 |
|
VHL |
7428 |
P40337 |
0.68 |
|
H2AFY |
9555 |
O75367 |
0.72 |
|
MAU2 |
23383 |
Q9Y6X3 |
0.72 |
|
RB1 |
5925 |
P06400 |
0.75 |
|
BAP1 |
8314 |
Q92560 |
0.76 |
|
USP17L2 |
377630 |
Q6R6M4 |
0.76 |
|
KMT5C |
84787 |
Q86Y97 |
0.78 |
|
EHMT2 |
10919 |
Q96KQ7 |
0.79 |
|
HIST3H3 |
8290 |
Q16695 |
0.84 |
|
POGZ |
23126 |
Q7Z3K3 |
0.87 |
|
EMSY |
56946 |
Q7Z589 |
0.90 |