PCOSBase

Protein Description

Gene Symbol	SF3A3
Entrez ID	10946
Uniprot ID	Q12874
Description	splicing factor 3a subunit 3
Chromosomal Location	chr1: 37,956,975-37,990,921

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000375	RNA splicing, via transesterification reactions	Splicing of RNA via a series of two transesterification reactions.	TAS
BP	GO:0000389	mRNA 3'-splice site recognition	Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome.	TAS
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	IC\|TAS
BP	GO:0006397	mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.	IMP
BP	GO:0008380	RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.	TAS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005681	spliceosomal complex	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.	IDA
CC	GO:0016607	nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.	IEA
CC	GO:0071013	catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.	IDA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	IBA
MF	GO:0008270	zinc ion binding	Interacting selectively and non-covalently with zinc (Zn) ions.	IEA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000690	Matrin/U1-C, C2H2-type zinc finger
IPR021966	Splicing factor SF3a60 binding domain
IPR024598	Domain of unknown function DUF3449
IPR031774	SF3A3 domain
IPR031776	Splicing factor 3A subunit 3

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Pathway ID	Pathway Term	Pathway Source
hsa03040	Spliceosome	KEGG
WP411	mRNA Processing	WikiPathways
WP410	Exercise-induced Circadian Regulation	WikiPathways

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UMLS CUI	UMLS Term
C0019693	HIV Infections

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Tissue	Cell Type
adrenal gland	glandular cells
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
kidney	cells in tubules
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
placenta	trophoblastic cells
rectum	glandular cells
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
DCTN1	1639	Q14203	0.49
GTF2F1	2962	P35269	0.49
SRPK1	6732	Q96SB4	0.49
TTC4	7268	O95801	0.49
VASP	7408	P50552	0.49
SRSF9	8683	Q13242	0.49
TOX4	9878	O94842	0.49
ACTR1A	10121	P61163	0.49
PSME3	10197	P61289	0.49
SF3B4	10262	Q15427	0.49
PRPF40B	25766	Q6NWY9	0.49
ISY1	57461	Q9ULR0	0.49
TSKS	60385	Q9UJT2	0.49
TRPM8	79054	Q7Z2W7	0.49
ZNF830	91603	Q96NB3	0.49
U2AF1	7307	Q01081	0.55
APP	351	P05067	0.56
PLRG1	5356	O43660	0.56
COPS3	8533	Q9UNS2	0.56
PRPF4	9128	O43172	0.56
XAB2	56949	Q9HCS7	0.56
SNRPA	6626	P09012	0.59
SART1	9092	O43290	0.59
ADAP1	11033	O75689	0.62
VAV2	7410	P52735	0.63
HGS	9146	O14964	0.63
PRMT5	10419	O14744	0.63
SF3B3	23450	Q15393	0.65
SF3B1	23451	O75533	0.65
CCDC85B	11007	Q15834	0.73
TRIM69	140691	Q86WT6	0.73
HSPB1	3315	P04792	0.76
TCERG1	10915	O14776	0.85
SF3A1	10291	Q15459	0.99
EEF1D	1936	P29692	0.49
EPB41	2035	P11171	0.49
FLNC	2318	Q14315	0.49
FOS	2353	P01100	0.49
HNRNPH3	3189	P31942	0.49
MCM4	4173	P33991	0.49
MCM5	4174	P33992	0.49
RAD21	5885	O60216	0.49
SNRPC	6631	P09234	0.49
PRPF3	9129	O43395	0.49
DDX23	9416	Q9BUQ8	0.49
MATR3	9782	P43243	0.49
ABI1	10006	Q8IZP0	0.49
HNRNPR	10236	O43390	0.49
POP1	10940	Q99575	0.49
WDHD1	11169	O75717	0.49
LSM4	25804	Q9Y4Z0	0.49
ZNF638	27332	Q14966	0.49
DDB1	100290337	Q16531	0.49
DHX15	1665	O43143	0.56
SNRPD1	6632	P62314	0.56
SNRPD2	6633	P62316	0.56
SNRPD3	6634	P62318	0.56
SNRNP200	23020	O75643	0.56
PRPF6	24148	O94906	0.56
EIF4G1	1981	Q04637	0.59
SNRNP70	6625	P08621	0.59
SNRPB2	6629	P08579	0.59
DDX46	9879	Q7L014	0.59
PRPF19	27339	Q9UMS4	0.59
ACTN4	81	O43707	0.63
ACTN1	87	P12814	0.63
CDC5L	988	Q99459	0.63
CHM	1121	P24386	0.63
EEF1G	1937	P26641	0.63
FUS	2521	P35637	0.63
JUN	3725	P05412	0.63
MDM2	4193	Q00987	0.63
MTNR1B	4544	P49286	0.63
NEDD8	4738	Q15843	0.63
NTRK1	4914	P04629	0.63
PSMA3	5684	P25788	0.63
RNF2	6045	Q99496	0.63
SNRPB	6628	P14678	0.63
TCF3	6929	P15923	0.63
SF1	7536	Q15637	0.63
ZNF212	7988	Q9UDV6	0.63
ZRSR2	8233	Q15696	0.63
HIST1H3A	8350	P68431	0.63
EED	8726	O75530	0.63
CUL7	9820	Q14999	0.63
HUWE1	10075	Q7Z6Z7	0.63
RBM7	10179	Q9Y580	0.63
STAM2	10254	O75886	0.63
UBD	10537	O15205	0.63
SPIN1	10927	Q9Y657	0.63
COPS5	10987	Q92905	0.63
SNW1	22938	Q13573	0.63
OBSL1	23363	O75147	0.63
ZDHHC17	23390	Q8IUH5	0.63
QPRT	23475	Q15274	0.63
SUZ12	23512	Q15022	0.63
FTSJ1	24140	Q9UET6	0.63
DDX41	51428	Q9UJV9	0.63
WWOX	51741	Q9NZC7	0.63
FBXW7	55294	Q969H0	0.63
CAND1	55832	Q86VP6	0.63
SREK1	140890	Q8WXA9	0.63
CDAN1	146059	Q8IWY9	0.63
PRPF31	26121	Q8WWY3	0.65
APBB1	322	O00213	0.68
WBP4	11193	O75554	0.68
PRPF40A	55660	O75400	0.68
FN1	2335	P02751	0.72
RAE1	8480	P78406	0.72
EMC2	9694	Q15006	0.72
RNPS1	10921	Q15287	0.72
FOXB1	27023	Q99853	0.72
FOXQ1	94234	Q9C009	0.72
TADA2A	6871	O75478	0.73
SMNDC1	10285	O75940	0.76
SF3A2	8175	Q15428	0.83
PUF60	22827	Q9UHX1	0.86
SNRPA1	6627	P09661	0.87