Protein Description

Gene Symbol NMU
Entrez ID 10874
Uniprot ID P48645
Description neuromedin U
Chromosomal Location chr4: 55,595,229-55,636,698
Ontology GO ID GO Term Definition Evidence

BP

GO:0001696

gastric acid secretion

The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.

IEA

BP

GO:0006940

regulation of smooth muscle contraction

Any process that modulates the frequency, rate or extent of smooth muscle contraction.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007186

G-protein coupled receptor signaling pathway

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).

TAS

BP

GO:0007218

neuropeptide signaling pathway

The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.

IEA

BP

GO:0007586

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

TAS

BP

GO:0009648

photoperiodism

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.

IEA

BP

GO:0019233

sensory perception of pain

The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.

IEA

BP

GO:0042755

eating behavior

The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.

IEA

BP

GO:0045987

positive regulation of smooth muscle contraction

Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.

IEA

BP

GO:0046887

positive regulation of hormone secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.

IEA

BP

GO:0050806

positive regulation of synaptic transmission

Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0043195

terminal bouton

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

IEA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042922

neuromedin U receptor binding

Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor.

IEA

Domain ID Description

IPR008200

Neuromedin U, C-terminal

IPR018070

Neuromedin U, amidation site

No pathways found.

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

TNS2

23371

Q63HR2

0.63

NOTCH2NL

388677

Q7Z3S9

0.63

SNTA1

6640

Q13424

0.49

HLA-DPA1

3113

P20036

0.63

KRTAP5-9

3846

P26371

0.63

B3GALNT1

8706

O75752

0.63

IL20RB

53833

Q6UXL0

0.63

GINM1

116254

Q9NU53

0.63

NMUR1

10316

Q9HB89

0.93

NMUR2

56923

Q9GZQ4

0.93