BP

GO:0006730

one-carbon metabolic process

The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.

IBA

BP

GO:0009396

folic acid-containing compound biosynthetic process

The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.

IEA

BP

GO:0046653

tetrahydrofolate metabolic process

The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

IDA

BP

GO:0046655

folic acid metabolic process

The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.

TAS

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IBA|ISS

CC

GO:0005759

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

TAS

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0004477

methenyltetrahydrofolate cyclohydrolase activity

Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

IBA|ISS|TAS

MF

GO:0004487

methylenetetrahydrofolate dehydrogenase (NAD+) activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.

IDA|TAS

MF

GO:0004488

methylenetetrahydrofolate dehydrogenase (NADP+) activity

Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.

IDA

MF

GO:0042301

phosphate ion binding

Interacting selectively and non-covalently with phosphate.

IDA