Protein Description

Gene Symbol CDH15
Entrez ID 1013
Uniprot ID P55291
Description cadherin 15, type 1, M-cadherin (myotubule)
Chromosomal Location chr16: 89,171,767-89,195,492
Ontology GO ID GO Term Definition Evidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

TAS

BP

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.

IEA

BP

GO:0034332

adherens junction organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.

TAS

BP

GO:0051149

positive regulation of muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005901

caveola

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0031594

neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR000233

Cadherin, cytoplasmic domain

IPR002126

Cadherin

IPR015919

Cadherin-like

IPR020894

Cadherin conserved site

IPR027397

Catenin binding domain

Pathway ID Pathway Term Pathway Source

hsa04514

Cell adhesion molecules (CAMs)

KEGG

No diseases found.

Tissue Cell Type

skeletal muscle

myocytes

smooth muscle

smooth muscle cells

Database Name

DisGeNET

Pubmed ID Author Year Title

21411543

Savaris et al.

2011

Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles

Gene Symbol Entrez ID Uniprot ID Score

SGTA

6449

O43765

0.63

CDH7

1005

Q9ULB5

0.52

CDH9

1007

Q9ULB4

0.52

CTNNA1

1495

P35221

0.52

CTNNB1

1499

P35222

0.52

JUP

3728

P14923

0.52

CDON

50937

Q4KMG0

0.65

BOC

91653

Q9BWV1

0.65

GNA12

2768

Q03113

0.78

ARVCF

421

O00192

0.86