Protein Description

Gene Symbol CHL1
Entrez ID 10752
Uniprot ID O00533
Description cell adhesion molecule L1-like
Chromosomal Location chr3: 196,596-409,417
Ontology GO ID GO Term Definition Evidence

BP

GO:0001764

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

IEA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007411

axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

IEA

BP

GO:0008344

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

IEA

BP

GO:0031103

axon regeneration

The regrowth of axons following their loss or damage.

IEA

BP

GO:0035640

exploration behavior

The specific behavior of an organism in response to a novel environment or stimulus.

IEA

BP

GO:0043524

negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

IEA

BP

GO:0050890

cognition

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

IEA

CC

GO:0005578

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0030425

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

IEA

CC

GO:0045177

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IEA

Domain ID Description

IPR003598

Immunoglobulin subtype 2

IPR003599

Immunoglobulin subtype

IPR003961

Fibronectin type III

IPR007110

Immunoglobulin-like domain

IPR013098

Immunoglobulin I-set

IPR013151

Immunoglobulin

IPR013783

Immunoglobulin-like fold

IPR026966

Neurofascin/L1/NrCAM, C-terminal domain

No pathways found.

UMLS CUI UMLS Term

C0028754

Obesity

C0036341

Schizophrenia

C3714756

Intellectual Disability

Tissue Cell Type

cerebral cortex

neuropil

colon

peripheral nerve/ganglion

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

E2F1

1869

Q01094

0.49

JUN

3725

P05412

0.49