Gene Symbol | CHL1 |
Entrez ID | 10752 |
Uniprot ID | O00533 |
Description | cell adhesion molecule L1-like |
Chromosomal Location | chr3: 196,596-409,417 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001764 |
neuron migration |
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
IEA |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0007411 |
axon guidance |
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
IEA |
BP |
GO:0008344 |
adult locomotory behavior |
Locomotory behavior in a fully developed and mature organism. |
IEA |
BP |
GO:0031103 |
axon regeneration |
The regrowth of axons following their loss or damage. |
IEA |
BP |
GO:0035640 |
exploration behavior |
The specific behavior of an organism in response to a novel environment or stimulus. |
IEA |
BP |
GO:0043524 |
negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
IEA |
BP |
GO:0050890 |
cognition |
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. |
IEA |
CC |
GO:0005578 |
proteinaceous extracellular matrix |
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
CC |
GO:0030425 |
dendrite |
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
IEA |
CC |
GO:0045177 |
apical part of cell |
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0002020 |
protease binding |
Interacting selectively and non-covalently with any protease or peptidase. |
IEA |
Domain ID | Description |
---|---|
IPR003598 |
Immunoglobulin subtype 2 |
IPR003599 |
Immunoglobulin subtype |
IPR003961 |
Fibronectin type III |
IPR007110 |
Immunoglobulin-like domain |
IPR013098 |
Immunoglobulin I-set |
IPR013151 |
Immunoglobulin |
IPR013783 |
Immunoglobulin-like fold |
IPR026966 |
Neurofascin/L1/NrCAM, C-terminal domain |
UMLS CUI | UMLS Term |
---|---|
C0028754 |
Obesity |
C0036341 |
Schizophrenia |
C3714756 |
Intellectual Disability |
Tissue | Cell Type |
---|---|
cerebral cortex |
neuropil |
colon |
peripheral nerve/ganglion |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
E2F1 |
1869 |
Q01094 |
0.49 |
JUN |
3725 |
P05412 |
0.49 |