Protein Description

Gene Symbol TNFSF13B
Entrez ID 10673
Uniprot ID Q9Y275
Description tumor necrosis factor superfamily member 13b
Chromosomal Location chr13: 108,251,240-108,308,484
Ontology GO ID GO Term Definition Evidence

BP

GO:0001782

B cell homeostasis

The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.

IEA

BP

GO:0002636

positive regulation of germinal center formation

Any process that activates or increases the frequency, rate, or extent of germinal center formation.

IEA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

TAS

BP

GO:0030890

positive regulation of B cell proliferation

Any process that activates or increases the rate or extent of B cell proliferation.

IMP

BP

GO:0031295

T cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.

IEA

BP

GO:0031296

B cell costimulation

The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.

IEA

BP

GO:0033209

tumor necrosis factor-mediated signaling pathway

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TAS

BP

GO:0042102

positive regulation of T cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.

IEA

BP

GO:0048305

immunoglobulin secretion

The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

TAS

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IEA

MF

GO:0005164

tumor necrosis factor receptor binding

Interacting selectively and non-covalently with the tumor necrosis factor receptor.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

Domain ID Description

IPR006052

Tumour necrosis factor domain

IPR008983

Tumour necrosis factor-like domain

Pathway ID Pathway Term Pathway Source

hsa04060

Cytokine-cytokine receptor interaction

KEGG

hsa04064

NF-kappa B signaling pathway

KEGG

hsa04672

Intestinal immune network for IgA production

KEGG

hsa05323

Rheumatoid arthritis

KEGG

WP2431

Spinal Cord Injury

WikiPathways

h_tall1Pathway

TACI and BCMA stimulation of B cell immune responses

BioCarta

No diseases found.

Tissue Cell Type

appendix

lymphoid tissue

bone marrow

hematopoietic cells

lymph node

germinal center cells

lymph node

non-germinal center cells

spleen

cells in red pulp

spleen

cells in white pulp

testis

cells in seminiferous ducts

tonsil

germinal center cells

tonsil

non-germinal center cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

FANCD2

2177

Q9BXW9

0.63

HLA-DPB1

3115

P04440

0.63

ITGA7

3679

Q13683

0.63

ITGB1

3688

P05556

0.63

MAP3K5

4217

Q99683

0.63

MFAP3

4238

P55082

0.63

NF1

4763

P21359

0.63

BTAF1

9044

O14981

0.63

MAP3K6

9064

O95382

0.63

PIGQ

9091

Q9BRB3

0.63

VTI1B

10490

Q9UEU0

0.63

IPO8

10526

O15397

0.63

IPO7

10527

O95373

0.63

MON2

23041

Q7Z3U7

0.63

CAND2

23066

O75155

0.63

TMEM131

23505

Q92545

0.63

PDSS1

23590

Q5T2R2

0.63

RANBP6

26953

O60518

0.63

HOOK2

29911

Q96ED9

0.63

TNPO2

30000

O14787

0.63

IPO11

51194

Q9UI26

0.63

HOOK1

51361

Q9UJC3

0.63

IMPAD1

54928

Q9NX62

0.63

FAM118A

55007

Q9NWS6

0.63

HEATR1

55127

Q9H583

0.63

TMEM39A

55254

Q9NV64

0.63

CHST12

55501

Q9NRB3

0.63

IPO9

55705

Q96P70

0.63

TTC17

55761

Q96AE7

0.63

FAM160B1

57700

Q5W0V3

0.63

NCAPG

64151

Q9BPX3

0.63

XPO4

64328

Q9C0E2

0.63

AKTIP

64400

Q9H8T0

0.63

NUP85

79902

Q9BW27

0.63

FAM160A2

84067

Q8N612

0.63

HOOK3

84376

Q86VS8

0.63

SAAL1

113174

Q96ER3

0.63

LRIG3

121227

Q6UXM1

0.63

ARSK

153642

Q6UWY0

0.63

BRAT1

221927

Q6PJG6

0.63

MAP3K15

389840

Q6ZN16

0.63

TNFSF13B

10673

Q9Y275

0.84

TNFRSF17

608

Q02223

0.90

TNFSF12

8742

O43508

0.63

TNFSF13

8741

O75888

0.73

TNFRSF13C

115650

Q96RJ3

0.89

TNFRSF13B

23495

O14836

0.90