Gene Symbol | TNFSF13B |
Entrez ID | 10673 |
Uniprot ID | Q9Y275 |
Description | tumor necrosis factor superfamily member 13b |
Chromosomal Location | chr13: 108,251,240-108,308,484 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001782 |
B cell homeostasis |
The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. |
IEA |
BP |
GO:0002636 |
positive regulation of germinal center formation |
Any process that activates or increases the frequency, rate, or extent of germinal center formation. |
IEA |
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0008283 |
cell proliferation |
The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
TAS |
BP |
GO:0008284 |
positive regulation of cell proliferation |
Any process that activates or increases the rate or extent of cell proliferation. |
TAS |
BP |
GO:0030890 |
positive regulation of B cell proliferation |
Any process that activates or increases the rate or extent of B cell proliferation. |
IMP |
BP |
GO:0031295 |
T cell costimulation |
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. |
IEA |
BP |
GO:0031296 |
B cell costimulation |
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. |
IEA |
BP |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
TAS |
BP |
GO:0042102 |
positive regulation of T cell proliferation |
Any process that activates or increases the rate or extent of T cell proliferation. |
IEA |
BP |
GO:0048305 |
immunoglobulin secretion |
The regulated release of immunoglobulins from a B cell or plasma cell, whose mechanism includes the use of alternate polyadenylylation signals to favor the biosynthesis of secreted forms of immunoglobulin over membrane-bound immunoglobulin. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
NAS |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IDA |
MF |
GO:0005102 |
receptor binding |
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
TAS |
MF |
GO:0005125 |
cytokine activity |
Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
IEA |
MF |
GO:0005164 |
tumor necrosis factor receptor binding |
Interacting selectively and non-covalently with the tumor necrosis factor receptor. |
IEA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
Domain ID | Description |
---|---|
IPR006052 |
Tumour necrosis factor domain |
IPR008983 |
Tumour necrosis factor-like domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04060 |
Cytokine-cytokine receptor interaction |
KEGG |
hsa04064 |
NF-kappa B signaling pathway |
KEGG |
hsa04672 |
Intestinal immune network for IgA production |
KEGG |
hsa05323 |
Rheumatoid arthritis |
KEGG |
WP2431 |
Spinal Cord Injury |
WikiPathways |
h_tall1Pathway |
TACI and BCMA stimulation of B cell immune responses |
BioCarta |
Tissue | Cell Type |
---|---|
appendix |
lymphoid tissue |
bone marrow |
hematopoietic cells |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
spleen |
cells in red pulp |
spleen |
cells in white pulp |
testis |
cells in seminiferous ducts |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
APP |
351 |
P05067 |
0.56 |
FANCD2 |
2177 |
Q9BXW9 |
0.63 |
HLA-DPB1 |
3115 |
P04440 |
0.63 |
ITGA7 |
3679 |
Q13683 |
0.63 |
ITGB1 |
3688 |
P05556 |
0.63 |
MAP3K5 |
4217 |
Q99683 |
0.63 |
MFAP3 |
4238 |
P55082 |
0.63 |
NF1 |
4763 |
P21359 |
0.63 |
BTAF1 |
9044 |
O14981 |
0.63 |
MAP3K6 |
9064 |
O95382 |
0.63 |
PIGQ |
9091 |
Q9BRB3 |
0.63 |
VTI1B |
10490 |
Q9UEU0 |
0.63 |
IPO8 |
10526 |
O15397 |
0.63 |
IPO7 |
10527 |
O95373 |
0.63 |
MON2 |
23041 |
Q7Z3U7 |
0.63 |
CAND2 |
23066 |
O75155 |
0.63 |
TMEM131 |
23505 |
Q92545 |
0.63 |
PDSS1 |
23590 |
Q5T2R2 |
0.63 |
RANBP6 |
26953 |
O60518 |
0.63 |
HOOK2 |
29911 |
Q96ED9 |
0.63 |
TNPO2 |
30000 |
O14787 |
0.63 |
IPO11 |
51194 |
Q9UI26 |
0.63 |
HOOK1 |
51361 |
Q9UJC3 |
0.63 |
IMPAD1 |
54928 |
Q9NX62 |
0.63 |
FAM118A |
55007 |
Q9NWS6 |
0.63 |
HEATR1 |
55127 |
Q9H583 |
0.63 |
TMEM39A |
55254 |
Q9NV64 |
0.63 |
CHST12 |
55501 |
Q9NRB3 |
0.63 |
IPO9 |
55705 |
Q96P70 |
0.63 |
TTC17 |
55761 |
Q96AE7 |
0.63 |
FAM160B1 |
57700 |
Q5W0V3 |
0.63 |
NCAPG |
64151 |
Q9BPX3 |
0.63 |
XPO4 |
64328 |
Q9C0E2 |
0.63 |
AKTIP |
64400 |
Q9H8T0 |
0.63 |
NUP85 |
79902 |
Q9BW27 |
0.63 |
FAM160A2 |
84067 |
Q8N612 |
0.63 |
HOOK3 |
84376 |
Q86VS8 |
0.63 |
SAAL1 |
113174 |
Q96ER3 |
0.63 |
LRIG3 |
121227 |
Q6UXM1 |
0.63 |
ARSK |
153642 |
Q6UWY0 |
0.63 |
BRAT1 |
221927 |
Q6PJG6 |
0.63 |
MAP3K15 |
389840 |
Q6ZN16 |
0.63 |
TNFSF13B |
10673 |
Q9Y275 |
0.84 |
TNFRSF17 |
608 |
Q02223 |
0.90 |
TNFSF12 |
8742 |
O43508 |
0.63 |
TNFSF13 |
8741 |
O75888 |
0.73 |
TNFRSF13C |
115650 |
Q96RJ3 |
0.89 |
TNFRSF13B |
23495 |
O14836 |
0.90 |