| Gene Symbol | FARS2 |
| Entrez ID | 10667 |
| Uniprot ID | O95363 |
| Description | phenylalanyl-tRNA synthetase 2, mitochondrial |
| Chromosomal Location | chr6: 5,261,044-5,771,580 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006418 | tRNA aminoacylation for protein translation |
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. | TAS |
BP | GO:0006432 | phenylalanyl-tRNA aminoacylation |
The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. | IDA |
BP | GO:0008033 | tRNA processing |
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. | IDA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IBA |
CC | GO:0005759 | mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. | TAS |
MF | GO:0000049 | tRNA binding |
Interacting selectively and non-covalently with transfer RNA. | IDA |
MF | GO:0000287 | magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. | IEA |
MF | GO:0004826 | phenylalanine-tRNA ligase activity |
Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). | IDA|TAS |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IEA |
| Domain ID | Description |
|---|---|
IPR002319 | Phenylalanyl-tRNA synthetase |
IPR004530 | Phenylalanyl-tRNA synthetase, class IIc, mitochondrial |
IPR005121 | Ferrodoxin-fold anticodon-binding domain |
IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00970 | Aminoacyl-tRNA biosynthesis | KEGG |
| UMLS CUI | UMLS Term |
|---|---|
C0028754 | Obesity |
C0162666 | Mitochondrial Encephalomyopathies |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 | Piltonen et al. | 2013 | Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
MID2 | 11043 | Q9UJV3 | 0.63 |
IKZF3 | 22806 | Q9UKT9 | 0.63 |
APPL1 | 26060 | Q9UKG1 | 0.63 |
ADAMTSL4 | 54507 | Q6UY14 | 0.63 |
AGTRAP | 57085 | Q6RW13 | 0.63 |
TRIM54 | 57159 | Q9BYV2 | 0.63 |
HMBOX1 | 79618 | Q6NT76 | 0.63 |
CMTM5 | 116173 | Q96DZ9 | 0.63 |
KRT40 | 125115 | Q6A162 | 0.63 |
KRTAP10-7 | 386675 | P60409 | 0.63 |
KRTAP10-9 | 386676 | P60411 | 0.63 |
KRTAP10-5 | 386680 | P60370 | 0.63 |
KRTAP10-3 | 386682 | P60369 | 0.63 |
NOTCH2NL | 388677 | Q7Z3S9 | 0.63 |
RCBTB2 | 1102 | O95199 | 0.63 |
ENO1 | 2023 | P06733 | 0.63 |
GAMT | 2593 | Q14353 | 0.63 |
HIST1H1A | 3024 | Q02539 | 0.63 |
HNRNPA1 | 3178 | P09651 | 0.63 |
KRT13 | 3860 | P13646 | 0.63 |
KRT31 | 3881 | Q15323 | 0.63 |
NEDD8 | 4738 | Q15843 | 0.63 |
YBX1 | 4904 | P67809 | 0.63 |
TRIM27 | 5987 | P14373 | 0.63 |
SHMT2 | 6472 | P34897 | 0.63 |
TADA2A | 6871 | O75478 | 0.63 |
TFCP2 | 7024 | Q12800 | 0.63 |
SUMO1 | 7341 | P63165 | 0.63 |
MKRN3 | 7681 | Q13064 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
STX11 | 8676 | O75558 | 0.63 |
ISG15 | 9636 | P05161 | 0.63 |
CALCOCO2 | 10241 | Q13137 | 0.63 |
NXF1 | 10482 | Q9UBU9 | 0.63 |
ZC3H3 | 23144 | Q8IXZ2 | 0.63 |
ICT1 | 3396 | Q14197 | 0.72 |
STAT5A | 6776 | P42229 | 0.72 |
TOMM40 | 10452 | O96008 | 0.72 |
CHST15 | 51363 | Q7LFX5 | 0.72 |
NEDD1 | 121441 | Q8NHV4 | 0.72 |
G3BP2 | 9908 | Q9UN86 | 0.76 |
USP45 | 85015 | Q70EL2 | 0.76 |