Gene Symbol | FARS2 |
Entrez ID | 10667 |
Uniprot ID | O95363 |
Description | phenylalanyl-tRNA synthetase 2, mitochondrial |
Chromosomal Location | chr6: 5,261,044-5,771,580 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006418 |
tRNA aminoacylation for protein translation |
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. |
TAS |
BP |
GO:0006432 |
phenylalanyl-tRNA aminoacylation |
The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. |
IDA |
BP |
GO:0008033 |
tRNA processing |
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
IDA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IBA |
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
MF |
GO:0000049 |
tRNA binding |
Interacting selectively and non-covalently with transfer RNA. |
IDA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IEA |
MF |
GO:0004826 |
phenylalanine-tRNA ligase activity |
Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). |
IDA|TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
Domain ID | Description |
---|---|
IPR002319 |
Phenylalanyl-tRNA synthetase |
IPR004530 |
Phenylalanyl-tRNA synthetase, class IIc, mitochondrial |
IPR005121 |
Ferrodoxin-fold anticodon-binding domain |
IPR006195 |
Aminoacyl-tRNA synthetase, class II |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00970 |
Aminoacyl-tRNA biosynthesis |
KEGG |
UMLS CUI | UMLS Term |
---|---|
C0028754 |
Obesity |
C0162666 |
Mitochondrial Encephalomyopathies |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MID2 |
11043 |
Q9UJV3 |
0.63 |
IKZF3 |
22806 |
Q9UKT9 |
0.63 |
APPL1 |
26060 |
Q9UKG1 |
0.63 |
ADAMTSL4 |
54507 |
Q6UY14 |
0.63 |
AGTRAP |
57085 |
Q6RW13 |
0.63 |
TRIM54 |
57159 |
Q9BYV2 |
0.63 |
HMBOX1 |
79618 |
Q6NT76 |
0.63 |
CMTM5 |
116173 |
Q96DZ9 |
0.63 |
KRT40 |
125115 |
Q6A162 |
0.63 |
KRTAP10-7 |
386675 |
P60409 |
0.63 |
KRTAP10-9 |
386676 |
P60411 |
0.63 |
KRTAP10-5 |
386680 |
P60370 |
0.63 |
KRTAP10-3 |
386682 |
P60369 |
0.63 |
NOTCH2NL |
388677 |
Q7Z3S9 |
0.63 |
RCBTB2 |
1102 |
O95199 |
0.63 |
ENO1 |
2023 |
P06733 |
0.63 |
GAMT |
2593 |
Q14353 |
0.63 |
HIST1H1A |
3024 |
Q02539 |
0.63 |
HNRNPA1 |
3178 |
P09651 |
0.63 |
KRT13 |
3860 |
P13646 |
0.63 |
KRT31 |
3881 |
Q15323 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
YBX1 |
4904 |
P67809 |
0.63 |
TRIM27 |
5987 |
P14373 |
0.63 |
SHMT2 |
6472 |
P34897 |
0.63 |
TADA2A |
6871 |
O75478 |
0.63 |
TFCP2 |
7024 |
Q12800 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
MKRN3 |
7681 |
Q13064 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
STX11 |
8676 |
O75558 |
0.63 |
ISG15 |
9636 |
P05161 |
0.63 |
CALCOCO2 |
10241 |
Q13137 |
0.63 |
NXF1 |
10482 |
Q9UBU9 |
0.63 |
ZC3H3 |
23144 |
Q8IXZ2 |
0.63 |
ICT1 |
3396 |
Q14197 |
0.72 |
STAT5A |
6776 |
P42229 |
0.72 |
TOMM40 |
10452 |
O96008 |
0.72 |
CHST15 |
51363 |
Q7LFX5 |
0.72 |
NEDD1 |
121441 |
Q8NHV4 |
0.72 |
G3BP2 |
9908 |
Q9UN86 |
0.76 |
USP45 |
85015 |
Q70EL2 |
0.76 |