Protein Description

Gene Symbol FARS2
Entrez ID 10667
Uniprot ID O95363
Description phenylalanyl-tRNA synthetase 2, mitochondrial
Chromosomal Location chr6: 5,261,044-5,771,580
Ontology GO ID GO Term Definition Evidence

BP

GO:0006418

tRNA aminoacylation for protein translation

The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis.

TAS

BP

GO:0006432

phenylalanyl-tRNA aminoacylation

The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA.

IDA

BP

GO:0008033

tRNA processing

The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IBA

CC

GO:0005759

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

TAS

MF

GO:0000049

tRNA binding

Interacting selectively and non-covalently with transfer RNA.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0004826

phenylalanine-tRNA ligase activity

Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR002319

Phenylalanyl-tRNA synthetase

IPR004530

Phenylalanyl-tRNA synthetase, class IIc, mitochondrial

IPR005121

Ferrodoxin-fold anticodon-binding domain

IPR006195

Aminoacyl-tRNA synthetase, class II

Pathway ID Pathway Term Pathway Source

hsa00970

Aminoacyl-tRNA biosynthesis

KEGG

UMLS CUI UMLS Term

C0028754

Obesity

C0162666

Mitochondrial Encephalomyopathies

No tissues found.

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

MID2

11043

Q9UJV3

0.63

IKZF3

22806

Q9UKT9

0.63

APPL1

26060

Q9UKG1

0.63

ADAMTSL4

54507

Q6UY14

0.63

AGTRAP

57085

Q6RW13

0.63

TRIM54

57159

Q9BYV2

0.63

HMBOX1

79618

Q6NT76

0.63

CMTM5

116173

Q96DZ9

0.63

KRT40

125115

Q6A162

0.63

KRTAP10-7

386675

P60409

0.63

KRTAP10-9

386676

P60411

0.63

KRTAP10-5

386680

P60370

0.63

KRTAP10-3

386682

P60369

0.63

NOTCH2NL

388677

Q7Z3S9

0.63

RCBTB2

1102

O95199

0.63

ENO1

2023

P06733

0.63

GAMT

2593

Q14353

0.63

HIST1H1A

3024

Q02539

0.63

HNRNPA1

3178

P09651

0.63

KRT13

3860

P13646

0.63

KRT31

3881

Q15323

0.63

NEDD8

4738

Q15843

0.63

YBX1

4904

P67809

0.63

TRIM27

5987

P14373

0.63

SHMT2

6472

P34897

0.63

TADA2A

6871

O75478

0.63

TFCP2

7024

Q12800

0.63

SUMO1

7341

P63165

0.63

MKRN3

7681

Q13064

0.63

CUL3

8452

Q13618

0.63

STX11

8676

O75558

0.63

ISG15

9636

P05161

0.63

CALCOCO2

10241

Q13137

0.63

NXF1

10482

Q9UBU9

0.63

ZC3H3

23144

Q8IXZ2

0.63

ICT1

3396

Q14197

0.72

STAT5A

6776

P42229

0.72

TOMM40

10452

O96008

0.72

CHST15

51363

Q7LFX5

0.72

NEDD1

121441

Q8NHV4

0.72

G3BP2

9908

Q9UN86

0.76

USP45

85015

Q70EL2

0.76