BP

GO:0001501

skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

TAS

BP

GO:0001666

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

IEA

BP

GO:0001953

negative regulation of cell-matrix adhesion

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

IEA

BP

GO:0003073

regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

IEA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IDA

BP

GO:0008593

regulation of Notch signaling pathway

Any process that modulates the frequency, rate or extent of the Notch signaling pathway.

IEA

BP

GO:0009612

response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0014850

response to muscle activity

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.

IEA

BP

GO:0014911

positive regulation of smooth muscle cell migration

Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

IBA

BP

GO:0032355

response to estradiol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IEA

BP

GO:0044344

cellular response to fibroblast growth factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.

IEA

BP

GO:0071307

cellular response to vitamin K

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.

IDA

BP

GO:0071356

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

IEA

BP

GO:0071560

cellular response to transforming growth factor beta stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

IEA

BP

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IEA

BP

GO:1904209

positive regulation of chemokine (C-C motif) ligand 2 secretion

Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 2 secretion.

IEA

BP

GO:1990138

neuron projection extension

Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

IEA

BP

GO:1990523

bone regeneration

The regrowth of bone following its loss or destruction.

IEA

CC

GO:0005578

proteinaceous extracellular matrix

A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.

IBA|ISS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IBA

CC

GO:0005802

trans-Golgi network

The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

IDA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA

CC

GO:0031594

neuromuscular junction

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

ISS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IDA

MF

GO:0050839

cell adhesion molecule binding

Interacting selectively and non-covalently with a cell adhesion molecule.

IBA