| Gene Symbol | MYL12A |
| Entrez ID | 10627 |
| Uniprot ID | P19105 |
| Description | myosin light chain 12A |
| Chromosomal Location | chr18: 3,247,481-3,256,236 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006936 |
muscle contraction |
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. |
TAS |
|
BP |
GO:0048013 |
ephrin receptor signaling pathway |
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. |
TAS |
|
BP |
GO:0070527 |
platelet aggregation |
The adhesion of one platelet to one or more other platelets via adhesion molecules. |
IMP |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0016459 |
myosin complex |
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
IEA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005509 |
calcium ion binding |
Interacting selectively and non-covalently with calcium ions (Ca2+). |
IEA |
| Domain ID | Description |
|---|---|
|
IPR002048 |
EF-hand domain |
|
IPR011992 |
EF-hand domain pair |
|
IPR015070 |
DJBP, EF-hand domain |
|
IPR018247 |
EF-Hand 1, calcium-binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04510 |
Focal adhesion |
KEGG |
|
hsa04530 |
Tight junction |
KEGG |
|
hsa04611 |
Platelet activation |
KEGG |
|
hsa04670 |
Leukocyte transendothelial migration |
KEGG |
|
hsa04810 |
Regulation of actin cytoskeleton |
KEGG |
| Tissue | Cell Type |
|---|---|
|
smooth muscle |
smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
NDUFB4 |
4710 |
O95168 |
0.49 |
|
SLC25A3 |
5250 |
Q00325 |
0.49 |
|
RPL13 |
6137 |
P26373 |
0.49 |
|
RPL18 |
6141 |
Q07020 |
0.49 |
|
UQCRB |
7381 |
P14927 |
0.49 |
|
MRPS21 |
54460 |
P82921 |
0.49 |
|
GLS |
2744 |
O94925 |
0.63 |
|
MYL6 |
4637 |
P60660 |
0.63 |
|
HERC1 |
8925 |
Q15751 |
0.63 |
|
MYL9 |
10398 |
P24844 |
0.63 |
|
CDC42BPA |
8476 |
Q5VT25 |
0.68 |
|
IGBP1 |
3476 |
P78318 |
0.49 |
|
CAP1 |
10487 |
Q01518 |
0.49 |
|
SYNCRIP |
10492 |
O60506 |
0.49 |
|
HYPK |
25764 |
Q9NX55 |
0.49 |
|
ACTB |
60 |
P60709 |
0.55 |
|
PTEN |
5728 |
P60484 |
0.56 |
|
BRCA1 |
672 |
P38398 |
0.63 |
|
CD4 |
920 |
P01730 |
0.63 |
|
ECT2 |
1894 |
Q9H8V3 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
HSPB1 |
3315 |
P04792 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
LIG4 |
3981 |
P49917 |
0.63 |
|
MCC |
4163 |
P23508 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
NFKB1 |
4790 |
P19838 |
0.63 |
|
PARK2 |
5071 |
O60260 |
0.63 |
|
PRKAB1 |
5564 |
Q9Y478 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
SP1 |
6667 |
P08047 |
0.63 |
|
SVIL |
6840 |
O95425 |
0.63 |
|
TP53BP1 |
7158 |
Q12888 |
0.63 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.63 |
|
TP63 |
8626 |
Q9H3D4 |
0.63 |
|
MDC1 |
9656 |
Q14676 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
PAXIP1 |
22976 |
Q6ZW49 |
0.63 |
|
TNIK |
23043 |
Q9UKE5 |
0.63 |
|
RABL6 |
55684 |
Q3YEC7 |
0.63 |
|
LIN37 |
55957 |
Q96GY3 |
0.63 |
|
CDC73 |
79577 |
Q6P1J9 |
0.63 |
|
MYH14 |
79784 |
Q7Z406 |
0.63 |
|
COG3 |
83548 |
Q96JB2 |
0.63 |
|
LIN9 |
286826 |
Q5TKA1 |
0.63 |
|
CDKN2A |
1029 |
P42771 |
0.68 |
|
MYLK |
4638 |
Q15746 |
0.68 |
|
CIT |
11113 |
O14578 |
0.68 |
|
CAPZA2 |
830 |
P47755 |
0.72 |
|
MAP3K3 |
4215 |
Q99759 |
0.72 |
|
TNFRSF1A |
7132 |
P19438 |
0.72 |
|
IKBKG |
8517 |
Q9Y6K9 |
0.72 |
|
PDLIM7 |
9260 |
Q9NR12 |
0.72 |
|
RIPK3 |
11035 |
Q9Y572 |
0.72 |
|
ANLN |
54443 |
Q9NQW6 |
0.72 |
|
SUV39H2 |
79723 |
Q9H5I1 |
0.72 |
|
MYO19 |
80179 |
Q96H55 |
0.72 |
|
MYO18A |
399687 |
Q92614 |
0.72 |
|
VHL |
7428 |
P40337 |
0.76 |
|
EIF1B |
10289 |
O60739 |
0.76 |
|
GRB2 |
2885 |
P62993 |
0.78 |
|
MYH9 |
4627 |
P35579 |
0.82 |
|
CHUK |
1147 |
O15111 |
0.86 |
|
IKBKE |
9641 |
Q14164 |
0.86 |