| Gene Symbol | HEXIM1 |
| Entrez ID | 10614 |
| Uniprot ID | O94992 |
| Description | hexamethylene bis-acetamide inducible 1 |
| Chromosomal Location | chr17: 45,148,502-45,152,101 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
|
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
IEA |
|
BP |
GO:0045736 |
negative regulation of cyclin-dependent protein serine/threonine kinase activity |
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. |
IDA |
|
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
|
BP |
GO:1901798 |
positive regulation of signal transduction by p53 class mediator |
Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator. |
IMP |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
MF |
GO:0004861 |
cyclin-dependent protein serine/threonine kinase inhibitor activity |
Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0017069 |
snRNA binding |
Interacting selectively and non-covalently with a small nuclear RNA (snRNA). |
IDA |
|
MF |
GO:0097322 |
7SK snRNA binding |
Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA). |
IDA |
| Domain ID | Description |
|---|---|
|
IPR024872 |
HEXIM |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP3414 |
Initiation of transcription and translation elongation at the HIV-1 LTR |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CSNK2A1 |
1457 |
P68400 |
0.63 |
|
CSNK2A2 |
1459 |
P19784 |
0.63 |
|
CSNK2B |
1460 |
P67870 |
0.63 |
|
DHX9 |
1660 |
Q08211 |
0.63 |
|
EEF1A2 |
1917 |
Q05639 |
0.63 |
|
FHL2 |
2274 |
Q14192 |
0.63 |
|
HDAC1 |
3065 |
Q13547 |
0.63 |
|
TP53 |
7157 |
P04637 |
0.63 |
|
NSMAF |
8439 |
Q92636 |
0.63 |
|
AP1M1 |
8907 |
Q9BXS5 |
0.63 |
|
PEO1 |
56652 |
Q96RR1 |
0.63 |
|
UBE2O |
63893 |
Q9C0C9 |
0.63 |
|
EGLN3 |
112399 |
Q9H6Z9 |
0.63 |
|
OSBPL1A |
114876 |
Q9BXW6 |
0.63 |
|
EGFR |
1956 |
P00533 |
0.72 |
|
HEXIM1 |
10614 |
O94992 |
0.72 |
|
RELA |
5970 |
Q04206 |
0.85 |
|
LARP7 |
51574 |
Q4G0J3 |
0.85 |
|
RN7SK |
125050 |
N/A |
0.87 |
|
CCNT1 |
904 |
O60563 |
0.90 |
|
DDX1 |
1653 |
Q92499 |
0.49 |
|
DYNC1H1 |
1778 |
Q14204 |
0.49 |
|
CTTN |
2017 |
Q14247 |
0.49 |
|
HSPD1 |
3329 |
P10809 |
0.49 |
|
SRSF11 |
9295 |
Q05519 |
0.49 |
|
NUCKS1 |
64710 |
Q9H1E3 |
0.49 |
|
HIF1A |
3091 |
Q16665 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
SHMT2 |
6472 |
P34897 |
0.63 |
|
SURF2 |
6835 |
Q15527 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
POLA2 |
23649 |
Q14181 |
0.63 |
|
AFF4 |
27125 |
Q9UHB7 |
0.63 |
|
COPS7B |
64708 |
Q9H9Q2 |
0.63 |
|
RTN4IP1 |
84816 |
Q8WWV3 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.71 |
|
EPHA2 |
1969 |
P29317 |
0.72 |
|
NCAPH |
23397 |
Q15003 |
0.72 |
|
HAUS2 |
55142 |
Q9NVX0 |
0.72 |
|
ACTR5 |
79913 |
Q9H9F9 |
0.72 |
|
AFF1 |
4299 |
P51825 |
0.73 |
|
TERF1 |
7013 |
P54274 |
0.73 |
|
HEXIM2 |
124790 |
Q96MH2 |
0.73 |
|
TERF2 |
7014 |
Q15554 |
0.75 |
|
BRD4 |
23476 |
O60885 |
0.82 |
|
MEPCE |
56257 |
Q7L2J0 |
0.82 |
|
CCNT2 |
905 |
O60583 |
0.84 |
|
CDK9 |
1025 |
P50750 |
0.90 |