| Gene Symbol | PAICS |
| Entrez ID | 10606 |
| Uniprot ID | P22234 |
| Description | phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase |
| Chromosomal Location | chr4: 56,435,741-56,464,579 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006189 |
de novo' IMP biosynthetic process |
The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. |
IBA|IEA |
|
BP |
GO:0009113 |
purine nucleobase biosynthetic process |
The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. |
TAS |
|
BP |
GO:0009168 |
purine ribonucleoside monophosphate biosynthetic process |
The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar. |
TAS |
|
BP |
GO:0046084 |
adenine biosynthetic process |
The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. |
IBA |
|
BP |
GO:0098609 |
cell-cell adhesion |
The attachment of one cell to another cell via adhesion molecules. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA|TAS |
|
CC |
GO:0005913 |
cell-cell adherens junction |
An adherens junction which connects a cell to another cell. |
IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0004638 |
phosphoribosylaminoimidazole carboxylase activity |
Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). |
IBA|TAS |
|
MF |
GO:0004639 |
phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. |
TAS |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0042802 |
identical protein binding |
Interacting selectively and non-covalently with an identical protein or proteins. |
IPI |
|
MF |
GO:0098641 |
cadherin binding involved in cell-cell adhesion |
Any cadherin binding that occurs as part of the process of cell-cell adhesion. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000031 |
PurE domain |
|
IPR018236 |
SAICAR synthetase, conserved site |
|
IPR028923 |
SAICAR synthetase/ADE2, N-terminal |
|
IPR033626 |
Class II PurE |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00230 |
Purine metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuropil |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
glial cells |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ASNS |
440 |
P08243 |
0.49 |
|
ASS1 |
445 |
P00966 |
0.49 |
|
ETFA |
2108 |
P13804 |
0.49 |
|
HSPB1 |
3315 |
P04792 |
0.49 |
|
HSPE1 |
3336 |
P61604 |
0.49 |
|
IMPA2 |
3613 |
O14732 |
0.49 |
|
MIF |
4282 |
P14174 |
0.49 |
|
ABCC1 |
4363 |
P33527 |
0.49 |
|
PCBP1 |
5093 |
Q15365 |
0.49 |
|
PKLR |
5313 |
P30613 |
0.49 |
|
PKM |
5315 |
P14618 |
0.49 |
|
SHMT1 |
6470 |
P34896 |
0.49 |
|
PRDX2 |
7001 |
P32119 |
0.49 |
|
TKT |
7086 |
P29401 |
0.49 |
|
TTC1 |
7265 |
Q99614 |
0.49 |
|
UBE2B |
7320 |
P63146 |
0.49 |
|
UGP2 |
7360 |
Q16851 |
0.49 |
|
ZPR1 |
8882 |
O75312 |
0.49 |
|
STUB1 |
10273 |
Q9UNE7 |
0.49 |
|
TACC3 |
10460 |
Q9Y6A5 |
0.49 |
|
SSSCA1 |
10534 |
O60232 |
0.49 |
|
RPIA |
22934 |
P49247 |
0.49 |
|
RPAP1 |
26015 |
Q9BWH6 |
0.49 |
|
GLOD4 |
51031 |
Q9HC38 |
0.49 |
|
GLRX5 |
51218 |
Q86SX6 |
0.49 |
|
TMEM177 |
80775 |
Q53S58 |
0.49 |
|
GINS4 |
84296 |
Q9BRT9 |
0.49 |
|
UNK |
85451 |
Q9C0B0 |
0.49 |
|
ATIC |
471 |
P31939 |
0.56 |
|
PFAS |
5198 |
O15067 |
0.56 |
|
CHD3 |
1107 |
Q12873 |
0.63 |
|
PRKAG1 |
5571 |
P54619 |
0.63 |
|
SUPT5H |
6829 |
O00267 |
0.63 |
|
SWAP70 |
23075 |
Q9UH65 |
0.63 |
|
QRICH1 |
54870 |
Q2TAL8 |
0.63 |
|
NIF3L1 |
60491 |
Q9GZT8 |
0.63 |
|
L3MBTL2 |
83746 |
Q969R5 |
0.63 |
|
CEP76 |
79959 |
Q8TAP6 |
0.73 |
|
LNX1 |
84708 |
Q8TBB1 |
0.73 |
|
FXR2 |
9513 |
P51116 |
0.74 |
|
NUDT18 |
79873 |
Q6ZVK8 |
0.74 |
|
PAICS |
10606 |
P22234 |
0.86 |
|
ADSL |
158 |
P30566 |
0.49 |
|
ARF1 |
375 |
P84077 |
0.49 |
|
NDUFV1 |
4723 |
P49821 |
0.49 |
|
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI |
8339 |
P62807 |
0.49 |
|
PUM1 |
9698 |
Q14671 |
0.49 |
|
DAZAP1 |
26528 |
Q96EP5 |
0.49 |
|
MED4 |
29079 |
Q9NPJ6 |
0.49 |
|
UFM1 |
51569 |
P61960 |
0.49 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
CRY1 |
1407 |
Q16526 |
0.63 |
|
CRY2 |
1408 |
Q49AN0 |
0.63 |
|
FUS |
2521 |
P35637 |
0.63 |
|
GNAS |
2778 |
P63092 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PRKCSH |
5589 |
P14314 |
0.63 |
|
MAPK13 |
5603 |
O15264 |
0.63 |
|
SET |
6418 |
Q01105 |
0.63 |
|
SGK1 |
6446 |
O00141 |
0.63 |
|
SMARCD1 |
6602 |
Q96GM5 |
0.63 |
|
TIMP2 |
7077 |
P16035 |
0.63 |
|
TP53BP1 |
7158 |
Q12888 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
VCAM1 |
7412 |
P19320 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CCNA1 |
8900 |
P78396 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
FARSB |
10056 |
Q9NSD9 |
0.63 |
|
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
UBD |
10537 |
O15205 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
FTSJ1 |
24140 |
Q9UET6 |
0.63 |
|
MOB4 |
25843 |
Q9Y3A3 |
0.63 |
|
EEF2K |
29904 |
O00418 |
0.63 |
|
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
|
WWOX |
51741 |
Q9NZC7 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
|
GART |
2618 |
P22102 |
0.65 |
|
FN1 |
2335 |
P02751 |
0.72 |
|
GNAS |
2778 |
P84996 |
0.72 |
|
HLA-B |
3106 |
P01889 |
0.72 |
|
POLR2G |
5436 |
P62487 |
0.72 |
|
HNRNPA1L2 |
144983 |
Q32P51 |
0.72 |
|
TERF1 |
7013 |
P54274 |
0.73 |
|
EPB41 |
2035 |
P11171 |
0.76 |
|
EIF6 |
3692 |
P56537 |
0.76 |
|
MCC |
4163 |
P23508 |
0.76 |
|
PSMC4 |
5704 |
P43686 |
0.76 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.76 |
|
DGKE |
8526 |
P52429 |
0.76 |