PCOSBase

Protein Description

Gene Symbol	PAICS
Entrez ID	10606
Uniprot ID	P22234
Description	phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
Chromosomal Location	chr4: 56,435,741-56,464,579

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006189	de novo' IMP biosynthetic process	The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.	IBA\|IEA
BP	GO:0009113	purine nucleobase biosynthetic process	The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.	TAS
BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.	TAS
BP	GO:0046084	adenine biosynthetic process	The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.	IBA
BP	GO:0098609	cell-cell adhesion	The attachment of one cell to another cell via adhesion molecules.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IBA\|TAS
CC	GO:0005913	cell-cell adherens junction	An adherens junction which connects a cell to another cell.	IDA
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004638	phosphoribosylaminoimidazole carboxylase activity	Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2).	IBA\|TAS
MF	GO:0004639	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate.	TAS
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0042802	identical protein binding	Interacting selectively and non-covalently with an identical protein or proteins.	IPI
MF	GO:0098641	cadherin binding involved in cell-cell adhesion	Any cadherin binding that occurs as part of the process of cell-cell adhesion.	IDA

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Domain ID	Description
IPR000031	PurE domain
IPR018236	SAICAR synthetase, conserved site
IPR028923	SAICAR synthetase/ADE2, N-terminal
IPR033626	Class II PurE

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Pathway ID	Pathway Term	Pathway Source
hsa00230	Purine metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
cerebral cortex	glial cells
cerebral cortex	neuropil
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	glial cells
kidney	cells in tubules
liver	hepatocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
parathyroid gland	glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
seminal vesicle	glandular cells
skin	keratinocytes
skin	epidermal cells
small intestine	glandular cells
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
12734205	Wood et al.	2003	The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol	Entrez ID	Uniprot ID	Score
ASNS	440	P08243	0.49
ASS1	445	P00966	0.49
ETFA	2108	P13804	0.49
HSPB1	3315	P04792	0.49
HSPE1	3336	P61604	0.49
IMPA2	3613	O14732	0.49
MIF	4282	P14174	0.49
ABCC1	4363	P33527	0.49
PCBP1	5093	Q15365	0.49
PKLR	5313	P30613	0.49
PKM	5315	P14618	0.49
SHMT1	6470	P34896	0.49
PRDX2	7001	P32119	0.49
TKT	7086	P29401	0.49
TTC1	7265	Q99614	0.49
UBE2B	7320	P63146	0.49
UGP2	7360	Q16851	0.49
ZPR1	8882	O75312	0.49
STUB1	10273	Q9UNE7	0.49
TACC3	10460	Q9Y6A5	0.49
SSSCA1	10534	O60232	0.49
RPIA	22934	P49247	0.49
RPAP1	26015	Q9BWH6	0.49
GLOD4	51031	Q9HC38	0.49
GLRX5	51218	Q86SX6	0.49
TMEM177	80775	Q53S58	0.49
GINS4	84296	Q9BRT9	0.49
UNK	85451	Q9C0B0	0.49
ATIC	471	P31939	0.56
PFAS	5198	O15067	0.56
CHD3	1107	Q12873	0.63
PRKAG1	5571	P54619	0.63
SUPT5H	6829	O00267	0.63
SWAP70	23075	Q9UH65	0.63
QRICH1	54870	Q2TAL8	0.63
NIF3L1	60491	Q9GZT8	0.63
L3MBTL2	83746	Q969R5	0.63
CEP76	79959	Q8TAP6	0.73
LNX1	84708	Q8TBB1	0.73
FXR2	9513	P51116	0.74
NUDT18	79873	Q6ZVK8	0.74
PAICS	10606	P22234	0.86
ADSL	158	P30566	0.49
ARF1	375	P84077	0.49
NDUFV1	4723	P49821	0.49
HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI	8339	P62807	0.49
PUM1	9698	Q14671	0.49
DAZAP1	26528	Q96EP5	0.49
MED4	29079	Q9NPJ6	0.49
UFM1	51569	P61960	0.49
CDK2	1017	P24941	0.63
CRY1	1407	Q16526	0.63
CRY2	1408	Q49AN0	0.63
FUS	2521	P35637	0.63
GNAS	2778	P63092	0.63
HLA-B	3106	P30480	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
NTRK1	4914	P04629	0.63
PRKCSH	5589	P14314	0.63
MAPK13	5603	O15264	0.63
SET	6418	Q01105	0.63
SGK1	6446	O00141	0.63
SMARCD1	6602	Q96GM5	0.63
TIMP2	7077	P16035	0.63
TP53BP1	7158	Q12888	0.63
SUMO1	7341	P63165	0.63
VCAM1	7412	P19320	0.63
CUL3	8452	Q13618	0.63
CCNA1	8900	P78396	0.63
KIAA0101	9768	Q15004	0.63
FARSB	10056	Q9NSD9	0.63
HUWE1	10075	Q7Z6Z7	0.63
EIF1B	10289	O60739	0.63
UBD	10537	O15205	0.63
GABARAPL2	11345	P60520	0.63
GABARAPL1	23710	Q9H0R8	0.63
FTSJ1	24140	Q9UET6	0.63
MOB4	25843	Q9Y3A3	0.63
EEF2K	29904	O00418	0.63
SIRT7	51547	Q9NRC8	0.63
WWOX	51741	Q9NZC7	0.63
OTUB1	55611	Q96FW1	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
GART	2618	P22102	0.65
FN1	2335	P02751	0.72
GNAS	2778	P84996	0.72
HLA-B	3106	P01889	0.72
POLR2G	5436	P62487	0.72
HNRNPA1L2	144983	Q32P51	0.72
TERF1	7013	P54274	0.73
EPB41	2035	P11171	0.76
EIF6	3692	P56537	0.76
MCC	4163	P23508	0.76
PSMC4	5704	P43686	0.76
TRAF6	7189	Q9Y4K3	0.76
DGKE	8526	P52429	0.76