PCOSBase

Protein Description

Gene Symbol	CCT7
Entrez ID	10574
Uniprot ID	Q99832
Description	chaperonin containing TCP1, subunit 7 (eta)
Chromosomal Location	chr2: 73,233,420-73,253,021

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006457	protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.	TAS
BP	GO:0007339	binding of sperm to zona pellucida	The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.	IEA
BP	GO:0032212	positive regulation of telomere maintenance via telomerase	Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.	IMP
BP	GO:0050821	protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.	IMP
BP	GO:1901998	toxin transport	The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	IEA
BP	GO:1904851	positive regulation of establishment of protein localization to telomere	Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.	IMP
BP	GO:1904871	positive regulation of protein localization to Cajal body	Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.	IMP
BP	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.	IMP
CC	GO:0002199	zona pellucida receptor complex	A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	TAS
CC	GO:0005739	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	IEA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0005832	chaperonin-containing T-complex	A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.	IDA\|TAS
CC	GO:0005874	microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.	IDA
CC	GO:0044297	cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.	IEA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0042802	identical protein binding	Interacting selectively and non-covalently with an identical protein or proteins.	IEA
MF	GO:0051082	unfolded protein binding	Interacting selectively and non-covalently with an unfolded protein.	IEA

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Domain ID	Description
IPR002194	Chaperonin TCP-1, conserved site
IPR002423	Chaperonin Cpn60/TCP-1 family
IPR012720	T-complex protein 1, eta subunit
IPR017998	Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409	GroEL-like apical domain
IPR027413	GroEL-like equatorial domain

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No pathways found.

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UMLS CUI	UMLS Term
C0019693	HIV Infections
C0038356	Stomach Neoplasms
C0242656	Disease Progression

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
colon	glandular cells
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
liver	bile duct cells
lymph node	germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
skeletal muscle	myocytes
skin	epidermal cells
small intestine	glandular cells
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	germinal center cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
KPNA3	3840	O00505	0.49
RPN1	6184	P04843	0.49
UQCRC2	7385	P22695	0.49
LAGE3	8270	Q14657	0.49
TRIM28	10155	Q13263	0.49
APP	351	P05067	0.56
EEF1G	1937	P26641	0.63
GCNT1	2650	Q02742	0.63
MED31	51003	Q9Y3C7	0.63
CCT8	10694	P50990	0.74
CCT6A	908	P40227	0.80
TCP1	6950	P17987	0.88
ATP1A1	476	P05023	0.49
ATP1A2	477	P50993	0.49
ATP1A3	478	P13637	0.49
CETN2	1069	P41208	0.49
DES	1674	P17661	0.49
EEF1D	1936	P29692	0.49
P4HB	5034	P07237	0.49
SSR4	6748	P51571	0.49
STUB1	10273	Q9UNE7	0.49
B9D1	27077	Q9UPM9	0.49
EHD2	30846	Q9NZN4	0.49
MKS1	54903	Q9NXB0	0.49
PDCL3	79031	Q9H2J4	0.49
CEP19	84984	Q96LK0	0.49
SSX2IP	117178	Q9Y2D8	0.49
CCNC	892	P24863	0.52
BTRC	8945	Q9Y297	0.52
OLR1	4973	P78380	0.56
PEX14	5195	O75381	0.56
CCT6B	10693	Q92526	0.56
ACTL6A	86	O96019	0.63
ANXA1	301	P04083	0.63
ANXA7	310	P20073	0.63
ATP5C1	509	P36542	0.63
MPPED1	758	O15442	0.63
CDC5L	988	Q99459	0.63
CDC20	991	Q12834	0.63
CDK4	1019	P11802	0.63
CDK9	1025	P50750	0.63
CDKN1A	1026	P38936	0.63
CEBPE	1053	Q15744	0.63
RCC1	1104	P18754	0.63
CRMP1	1400	Q14194	0.63
CSNK1E	1454	P49674	0.63
DNM2	1785	P50570	0.63
ENO1	2023	P06733	0.63
ESR2	2100	Q92731	0.63
FN1	2335	P02751	0.63
FUS	2521	P35637	0.63
GRB2	2885	P62993	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
KRAS	3845	P01116	0.63
LFNG	3955	Q8NES3	0.63
LGALS3BP	3959	Q08380	0.63
MCM2	4171	P49736	0.63
MDM2	4193	Q00987	0.63
MOV10	4343	Q9HCE1	0.63
MYBPC3	4607	Q14896	0.63
NKX3-1	4824	Q99801	0.63
NOS2	4843	P35228	0.63
NTRK1	4914	P04629	0.63
PEX7	5191	O00628	0.63
PHKG2	5261	P15735	0.63
PPP2R2A	5520	P63151	0.63
PRKAA1	5562	Q13131	0.63
PRKACB	5567	P22694	0.63
MAPK10	5602	P53779	0.63
PSMA2	5683	P25787	0.63
RAD21	5885	O60216	0.63
RAP1B	5908	P61224	0.63
RPS6KA1	6195	Q15418	0.63
RPS6KB2	6199	Q9UBS0	0.63
SUMO2	6613	P61956	0.63
TFAP2C	7022	Q92754	0.63
THBS3	7059	P49746	0.63
TSSC1	7260	Q53HC9	0.63
VCP	7415	P55072	0.63
GAN	8139	Q9H2C0	0.63
CUL3	8452	Q13618	0.63
DCAF5	8816	Q96JK2	0.63
BUB3	9184	O43684	0.63
BAG3	9531	O95817	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
HDAC6	10013	Q9UBN7	0.63
HDAC5	10014	Q9UQL6	0.63
HUWE1	10075	Q7Z6Z7	0.63
ACTR1B	10120	P42025	0.63
TXNDC9	10190	O14530	0.63
DCAF7	10238	P61962	0.63
NXF1	10482	Q9UBU9	0.63
STK25	10494	O00506	0.63
KAT5	10524	Q92993	0.63
UBD	10537	O15205	0.63
GABARAPL2	11345	P60520	0.63
WDR37	22884	Q9Y2I8	0.63
SNW1	22938	Q13573	0.63
LARP1	23367	Q6PKG0	0.63
METTL21B	25895	Q96AZ1	0.63
SEC31B	25956	Q9NQW1	0.63
TTLL3	26140	Q9Y4R7	0.63
FBXW8	26259	Q8N3Y1	0.63
FBXO25	26260	Q8TCJ0	0.63
FBXO6	26270	Q9NRD1	0.63
STRN4	29888	Q9NRL3	0.63
WWOX	51741	Q9NZC7	0.63
RIOK2	55781	Q9BVS4	0.63
NXF5	55998	Q9H1B4	0.63
SMURF1	57154	Q9HCE7	0.63
AICDA	57379	Q9GZX7	0.63
MLST8	64223	Q9BVC4	0.63
RFWD2	64326	Q8NHY2	0.63
FYCO1	79443	Q9BQS8	0.63
TUBAL3	79861	A6NHL2	0.63
WDR76	79968	Q9H967	0.63
DOCK5	80005	Q9H7D0	0.63
WDR82	80335	Q6UXN9	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
CCDC8	83987	Q9H0W5	0.63
WDR83	84292	Q9BRX9	0.63
MAP1LC3A	84557	Q9H492	0.63
UBASH3B	84959	Q8TF42	0.63
ALKBH8	91801	Q96BT7	0.63
METTL18	92342	O95568	0.63
TUBA3E	112714	Q6PEY2	0.63
TP53RK	112858	Q96S44	0.63
LRRC28	123355	Q86X40	0.63
SEPT12	124404	Q8IYM1	0.63
METTL6	131965	Q8TCB7	0.63
PACRG	135138	Q96M98	0.63
ASB7	140460	Q9H672	0.63
TUBB2B	347733	Q9BVA1	0.63
NUP43	348995	Q8NFH3	0.63
FAM86B2	653333	P0C5J1	0.63
SUMO4	387082	Q6EEV6	0.65
YWHAZ	7534	P63104	0.68
PRPF40A	55660	O75400	0.68
CDK1	983	P06493	0.72
DDB2	1643	Q92466	0.72
HDAC1	3065	Q13547	0.72
IRAK1	3654	P51617	0.72
MAP3K3	4215	Q99759	0.72
PDK3	5165	Q15120	0.72
PPP2R4	5524	Q15257	0.72
TYK2	7297	P29597	0.72
NSMAF	8439	Q92636	0.72
NIPSNAP1	8508	Q9BPW8	0.72
HDAC3	8841	O15379	0.72
PRPF4	9128	O43172	0.72
ACTR2	10097	P61160	0.72
SGK2	10110	Q9HBY8	0.72
RIPK3	11035	Q9Y572	0.72
MOB4	25843	Q9Y3A3	0.72
TBK1	29110	Q9UHD2	0.72
ATG16L1	55054	Q676U5	0.72
RFWD3	55159	Q6PCD5	0.72
KIF21A	55605	Q7Z4S6	0.72
PPP2R2D	55844	Q66LE6	0.72
SEH1L	81929	Q96EE3	0.72
TSSK6	83983	Q9BXA6	0.72
TUBA1C	84790	Q9BQE3	0.72
ARMC6	93436	Q6NXE6	0.72
POC1A	25886	Q8NBT0	0.73
CDK2	1017	P24941	0.73
FBXW4	6468	P57775	0.73
VHL	7428	P40337	0.73
CCT3	7203	P49368	0.74
CCT5	22948	P48643	0.74
PPP2R2B	5521	Q00005	0.75
STK24	8428	Q9Y6E0	0.76
CCT4	10575	P50991	0.80
CCT2	10576	P78371	0.80
ESR1	2099	P03372	0.82
STK4	6789	Q13043	0.82
TUBG1	7283	P23258	0.82
VCAM1	7412	P19320	0.82
SSSCA1	10534	O60232	0.82
WRAP53	55135	Q9BUR4	0.82
NEDD1	121441	Q8NHV4	0.82
TP53	7157	P04637	0.83
CDK5	1020	Q00535	0.86
PAN2	9924	Q504Q3	0.86
ILK	3611	Q13418	0.87
PPP2CA	5515	P67775	0.87
STRN	6801	O43815	0.87
STRN3	29966	Q13033	0.87
PPP2CB	5516	P62714	0.89
PPP2R2C	5522	Q9Y2T4	0.89
PPP4C	5531	P60510	0.89
IGBP1	3476	P78318	0.94