Protein Description

Gene Symbol ZNHIT1
Entrez ID 10467
Uniprot ID O43257
Description zinc finger, HIT-type containing 1
Chromosomal Location chr7: 101,217,668-101,224,190
Ontology GO ID GO Term Definition Evidence

BP

GO:0031063

regulation of histone deacetylation

Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.

IBA

BP

GO:0043486

histone exchange

The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.

IBA

CC

GO:0000812

Swr1 complex

A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.

IBA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0031491

nucleosome binding

Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

IBA

MF

GO:0042826

histone deacetylase binding

Interacting selectively and non-covalently with the enzyme histone deacetylase.

IBA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR007529

Zinc finger, HIT-type

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

placenta

decidual cells

placenta

trophoblastic cells

rectum

glandular cells

skin

melanocytes

small intestine

glandular cells

thyroid gland

glandular cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

TP53

7157

P04637

0.62

DAPP1

27071

Q9UN19

0.63

KRTAP10-7

386675

P60409

0.63

CSNK2B

1460

P67870

0.73

H2AFZ

3015

P0C0S5

0.76

MAPK11

5600

Q15759

0.76

VPS72

6944

Q15906

0.82

RUVBL1

8607

Q9Y265

0.82

SRCAP

10847

Q6ZRS2

0.82

RUVBL2

10856

Q9Y230

0.82

DMAP1

55929

Q9NPF5

0.82

ACTL6A

86

O96019

0.86

YEATS4

8089

O95619

0.87

ACTR6

64431

Q9GZN1

0.87

MAPK14

1432

Q16539

0.88

GRB7

2886

Q14451

0.63

SH2D1A

4068

O60880

0.63

UBC

7316

P0CG48

0.63

TNIP1

10318

Q15025

0.63

HINFP

25988

Q9BQA5

0.63

HIST1H2BA

255626

Q96A08

0.63

TP53BP1

7158

Q12888

0.68

LCA5

167691

Q86VQ0

0.72