BP

GO:0002376

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

IEA

BP

GO:0007080

mitotic metaphase plate congression

The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.

IMP

BP

GO:0010531

activation of JAK1 kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK1 (Janus Activated Kinase 1) protein, thereby activating it.

IDA

BP

GO:0031393

negative regulation of prostaglandin biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.

IDA

BP

GO:0032695

negative regulation of interleukin-12 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.

IDA

BP

GO:0032733

positive regulation of interleukin-10 production

Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.

IDA

BP

GO:0032815

negative regulation of natural killer cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.

IDA

BP

GO:0035058

nonmotile primary cilium assembly

The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.

IMP

BP

GO:0042521

negative regulation of tyrosine phosphorylation of Stat4 protein

Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.

IDA

BP

GO:0042526

positive regulation of tyrosine phosphorylation of Stat6 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.

IDA

BP

GO:0071539

protein localization to centrosome

A process in which a protein is transported to, or maintained at, the centrosome.

IMP

BP

GO:0090307

mitotic spindle assembly

The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis.

IMP

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IDA

CC

GO:0034451

centriolar satellite

A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.

IDA

MF

GO:0005136

interleukin-4 receptor binding

Interacting selectively and non-covalently with the interleukin-4 receptor.

IDA