| Gene Symbol | PGRMC2 |
| Entrez ID | 10424 |
| Uniprot ID | O15173 |
| Description | progesterone receptor membrane component 2 |
| Chromosomal Location | chr4: 128,269,237-128,288,829 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0043401 |
steroid hormone mediated signaling pathway |
A series of molecular signals mediated by a steroid hormone binding to a receptor. |
IEA |
|
CC |
GO:0005635 |
nuclear envelope |
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
IDA |
|
CC |
GO:0012505 |
endomembrane system |
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
IBA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0003707 |
steroid hormone receptor activity |
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
TAS |
|
MF |
GO:0005496 |
steroid binding |
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
IEA |
|
MF |
GO:0020037 |
heme binding |
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR001199 |
Cytochrome b5-like heme/steroid binding domain |
| Tissue | Cell Type |
|---|---|
|
colon |
endothelial cells |
|
duodenum |
glandular cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
seminal vesicle |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
15308691 |
Jansen et al. |
2004 |
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ABCC1 |
4363 |
P33527 |
0.49 |
|
NUP160 |
23279 |
Q12769 |
0.49 |
|
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
|
TMEM216 |
51259 |
Q9P0N5 |
0.49 |
|
TCTN2 |
79867 |
Q96GX1 |
0.49 |
|
TMEM67 |
91147 |
Q5HYA8 |
0.49 |
|
NUP35 |
129401 |
Q8NFH5 |
0.49 |
|
EVC2 |
132884 |
Q86UK5 |
0.49 |
|
TMEM17 |
200728 |
Q86X19 |
0.49 |
|
LMNA |
4000 |
P02545 |
0.59 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
PMF1 |
11243 |
Q6P1K2 |
0.63 |
|
DERL1 |
79139 |
Q9BUN8 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |