Protein Description

Gene Symbol PGRMC2
Entrez ID 10424
Uniprot ID O15173
Description progesterone receptor membrane component 2
Chromosomal Location chr4: 128,269,237-128,288,829
Ontology GO ID GO Term Definition Evidence

BP

GO:0043401

steroid hormone mediated signaling pathway

A series of molecular signals mediated by a steroid hormone binding to a receptor.

IEA

CC

GO:0005635

nuclear envelope

The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

IDA

CC

GO:0012505

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

IBA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0003707

steroid hormone receptor activity

Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.

TAS

MF

GO:0005496

steroid binding

Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

IEA

MF

GO:0020037

heme binding

Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.

IBA

Domain ID Description

IPR001199

Cytochrome b5-like heme/steroid binding domain

No pathways found.

No diseases found.

Tissue Cell Type

colon

endothelial cells

duodenum

glandular cells

pancreas

exocrine glandular cells

placenta

decidual cells

placenta

trophoblastic cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

15308691

Jansen et al.

2004

Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ABCC1

4363

P33527

0.49

NUP160

23279

Q12769

0.49

TCTN3

26123

Q6NUS6

0.49

TMEM216

51259

Q9P0N5

0.49

TCTN2

79867

Q96GX1

0.49

TMEM67

91147

Q5HYA8

0.49

NUP35

129401

Q8NFH5

0.49

EVC2

132884

Q86UK5

0.49

TMEM17

200728

Q86X19

0.49

LMNA

4000

P02545

0.59

NTRK1

4914

P04629

0.63

IKBKE

9641

Q14164

0.63

PMF1

11243

Q6P1K2

0.63

DERL1

79139

Q9BUN8

0.63

CCDC8

83987

Q9H0W5

0.63