Protein Description

Gene Symbol NSA2
Entrez ID 10412
Uniprot ID O95478
Description NSA2, ribosome biogenesis homolog
Chromosomal Location chr5: 74,766,991-74,780,113
Ontology GO ID GO Term Definition Evidence

BP

GO:0000460

maturation of 5.8S rRNA

Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.

IBA

BP

GO:0000470

maturation of LSU-rRNA

Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.

IBA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IBA|IDA

CC

GO:0030687

preribosome, large subunit precursor

A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

IBA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR022309

Ribosomal protein S8e/ribosomal biogenesis NSA2

No pathways found.

UMLS CUI UMLS Term

C0023892

Biliary Cirrhosis

Tissue Cell Type

cerebellum

Purkinje cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

kidney

cells in tubules

placenta

trophoblastic cells

rectum

glandular cells

skin

Langerhans

stomach

glandular cells

testis

Leydig cells

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

15291743

Diao et al.

2004

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray

Gene Symbol Entrez ID Uniprot ID Score

RPL27

6155

P61353

0.49

NOC2L

26155

Q9Y3T9

0.56

SDAD1

55153

Q9NVU7

0.56

NPM1

4869

P06748

0.63

RPS8

6202

P62241

0.63

PABPC4

8761

Q13310

0.63

ZNF646

9726

O15015

0.63

RRS1

23212

Q15050

0.63

RPL26L1

51121

Q9UNX3

0.63

PTCD3

55037

Q96EY7

0.63

MRPS9

64965

P82933

0.63

CCDC86

79080

Q9H6F5

0.63

TYW5

129450

A2RUC4

0.63

LIN28B

389421

Q6ZN17

0.63

MAGEA9; MAGEA9B

4108

P43362

0.63

GNL2

29889

Q13823

0.70

RSL24D1

51187

Q9UHA3

0.70

NLE1

54475

Q9NVX2

0.70

RPF2

84154

Q9H7B2

0.73

GTPBP4

23560

Q9BZE4

0.79

MRTO4

51154

Q9UKD2

0.79

RPL5

6125

P46777

0.49

EIF2S2

8894

P20042

0.49

EBNA1BP2

10969

Q99848

0.49

BRIX1

55299

Q8TDN6

0.49

DDX24

57062

Q9GZR7

0.49

NIFK

84365

Q9BYG3

0.49

TMEM67

91147

Q5HYA8

0.49

CNTROB

116840

Q8N137

0.49

FTSJ3

117246

Q8IY81

0.49

SPICE1

152185

Q8N0Z3

0.49

TMEM17

200728

Q86X19

0.49

NOP2

4839

P46087

0.56

DDX18

8886

Q9NVP1

0.56

PUM3

9933

Q15397

0.56

NOP56

10528

O00567

0.56

PES1

23481

O00541

0.56

HIST1H1A

3024

Q02539

0.63

MNDA

4332

P41218

0.63

RNF2

6045

Q99496

0.63

IRAK3

11213

Q9Y616

0.63

ZC3H3

23144

Q8IXZ2

0.63

SIRT7

51547

Q9NRC8

0.63

PRR11

55771

Q96HE9

0.63

NOL12

79159

Q9UGY1

0.63

CAMKK1

84254

Q8N5S9

0.72

RPL13

6137

P26373

0.73

IFI16

3428

Q16666

0.82