Protein Description

Gene Symbol MYL9
Entrez ID 10398
Uniprot ID P24844
Description myosin light chain 9
Chromosomal Location chr20: 36,541,484-36,551,447
Ontology GO ID GO Term Definition Evidence

BP

GO:0006936

muscle contraction

A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

TAS

BP

GO:0006937

regulation of muscle contraction

Any process that modulates the frequency, rate or extent of muscle contraction.

TAS

BP

GO:0070527

platelet aggregation

The adhesion of one platelet to one or more other platelets via adhesion molecules.

IMP

CC

GO:0001725

stress fiber

A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005859

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

TAS

CC

GO:0030018

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

IEA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0008307

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

TAS

MF

GO:0032036

myosin heavy chain binding

Interacting selectively and non-covalently with a heavy chain of a myosin complex.

IEA

Domain ID Description

IPR002048

EF-hand domain

IPR011992

EF-hand domain pair

IPR018247

EF-Hand 1, calcium-binding site

Pathway ID Pathway Term Pathway Source

hsa04022

cGMP-PKG signaling pathway

KEGG

hsa04024

cAMP signaling pathway

KEGG

hsa04270

Vascular smooth muscle contraction

KEGG

hsa04510

Focal adhesion

KEGG

hsa04530

Tight junction

KEGG

hsa04670

Leukocyte transendothelial migration

KEGG

hsa04810

Regulation of actin cytoskeleton

KEGG

hsa04921

Oxytocin signaling pathway

KEGG

WP383

Striated Muscle Contraction

WikiPathways

UMLS CUI UMLS Term

C0042373

Vascular Diseases

C1527311

Brain Edema

Tissue Cell Type

skin

epidermal cells

No databases found.

Pubmed ID Author Year Title

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

PIP4K2B

8396

P78356

0.49

EIF3I

8668

Q13347

0.49

EIF2S2

8894

P20042

0.49

PIP4K2C

79837

Q8TBX8

0.49

CDC42BPA

8476

Q5VT25

0.52

HSPB1

3315

P04792

0.63

MCM2

4171

P49736

0.63

SP1

6667

P08047

0.63

TP53

7157

P04637

0.63

TP73

7161

O15350

0.63

TP63

8626

Q9H3D4

0.63

MYL12A

10627

P19105

0.63

FBXO25

26260

Q8TCJ0

0.63

MYH14

79784

Q7Z406

0.63

FOXD3

27022

Q9UJU5

0.72

FOXP1

27086

Q9H334

0.72

MYH9

4627

P35579

0.82

LRRK2

120892

Q5S007

0.82