BP

GO:0001755

neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.

IBA

BP

GO:0001764

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

ISS

BP

GO:0002027

regulation of heart rate

Any process that modulates the frequency or rate of heart contraction.

IEA

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IEA

BP

GO:0007411

axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

TAS

BP

GO:0007413

axonal fasciculation

The collection of axons into a bundle of rods, known as a fascicle.

IEA

BP

GO:0010633

negative regulation of epithelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.

IEA

BP

GO:0010977

negative regulation of neuron projection development

Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

IMP

BP

GO:0021612

facial nerve structural organization

The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.

IEA

BP

GO:0021637

trigeminal nerve structural organization

The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.

IEA

BP

GO:0021675

nerve development

The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.

ISS

BP

GO:0021772

olfactory bulb development

The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.

IMP

BP

GO:0021785

branchiomotor neuron axon guidance

The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.

IEA

BP

GO:0021828

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.

IEA

BP

GO:0036486

ventral trunk neural crest cell migration

The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.

IEA

BP

GO:0048485

sympathetic nervous system development

The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.

TAS

BP

GO:0048813

dendrite morphogenesis

The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell.

IEA

BP

GO:0048841

regulation of axon extension involved in axon guidance

Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.

IDA

BP

GO:0048843

negative regulation of axon extension involved in axon guidance

Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.

IBA

BP

GO:0048846

axon extension involved in axon guidance

The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.

ISS

BP

GO:0048880

sensory system development

The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.

TAS

BP

GO:0050919

negative chemotaxis

The directed movement of a motile cell or organism towards a lower concentration of a chemical.

IEA

BP

GO:0060385

axonogenesis involved in innervation

The neurite development process that generates a long process of a neuron, as it invades a target tissue.

ISS

BP

GO:0060666

dichotomous subdivision of terminal units involved in salivary gland branching

The process in which a salivary epithelial cord bifurcates at its end.

IEA

BP

GO:0061549

sympathetic ganglion development

The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.

ISS

BP

GO:0061551

trigeminal ganglion development

The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.

IEA

BP

GO:0071526

semaphorin-plexin signaling pathway

A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.

TAS

BP

GO:0097490

sympathetic neuron projection extension

Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

ISS

BP

GO:0097491

sympathetic neuron projection guidance

The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.

ISS

BP

GO:1901166

neural crest cell migration involved in autonomic nervous system development

Any neural crest cell migration that is involved in autonomic nervous system development.

ISS

BP

GO:1902285

semaphorin-plexin signaling pathway involved in neuron projection guidance

Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance.

ISS

BP

GO:1902287

semaphorin-plexin signaling pathway involved in axon guidance

Any semaphorin-plexin signaling pathway that is involved in axon guidance.

IEA

BP

GO:1903045

neural crest cell migration involved in sympathetic nervous system development

Any neural crest cell migration that is involved in sympathetic nervous system development.

IEA

BP

GO:1903375

facioacoustic ganglion development

The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure.

IEA

BP

GO:2000020

positive regulation of male gonad development

Any process that activates or increases the frequency, rate or extent of male gonad development.

IEA

BP

GO:2001224

positive regulation of neuron migration

Any process that activates or increases the frequency, rate or extent of neuron migration.

IBA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IBA

CC

GO:0030424

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

IBA

CC

GO:0030425

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

IEA

MF

GO:0030215

semaphorin receptor binding

Interacting selectively and non-covalently with semaphorin receptors.

IBA

MF

GO:0038191

neuropilin binding

Interacting selectively and non-covalently with a member of the neuropilin family.

IBA|ISS

MF

GO:0045499

chemorepellent activity

Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.

TAS