PCOSBase

Protein Description

Gene Symbol	TFG
Entrez ID	10342
Uniprot ID	Q92734
Description	TRK-fused gene
Chromosomal Location	chr3: 100,709,331-100,748,966

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	IEA
BP	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.	IMP
BP	GO:0048208	COPII vesicle coating	The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.	TAS
CC	GO:0000139	Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	NAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
MF	GO:0004871	signal transducer activity	Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.	IMP
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0042802	identical protein binding	Interacting selectively and non-covalently with an identical protein or proteins.	IPI

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Domain ID	Description
IPR000270	PB1 domain
IPR033512	Protein TFG

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Pathway ID	Pathway Term	Pathway Source
hsa05200	Pathways in cancer	KEGG
hsa05216	Thyroid cancer	KEGG

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UMLS CUI	UMLS Term
C0017661	Iga Glomerulonephritis

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Tissue	Cell Type
appendix	glandular cells
cerebral cortex	glial cells
colon	glandular cells
duodenum	glandular cells
gallbladder	glandular cells
kidney	cells in tubules
pancreas	exocrine glandular cells
placenta	trophoblastic cells
rectum	glandular cells
salivary gland	glandular cells
small intestine	glandular cells
tonsil	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

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Gene Symbol	Entrez ID	Uniprot ID	Score
EIF1AX	1964	P47813	0.63
IGHG1	3500	P01857	0.63
PKP1	5317	Q13835	0.63
S100A3	6274	P33764	0.63
S100A7	6278	P31151	0.63
NCOA4	8031	Q13772	0.63
SELENBP1	8991	Q13228	0.63
MYOT	9499	Q9UBF9	0.63
SEC24A	10802	O95486	0.63
SPINK5	11005	Q9NQ38	0.63
RBPMS	11030	Q93062	0.63
DUSP14	11072	O95147	0.63
C14orf1	11161	Q9UKR5	0.63
ABI3BP	25890	Q7Z7G0	0.63
ARHGEF16	27237	Q5VV41	0.63
SPG21	51324	Q9NZD8	0.63
ARL15	54622	Q9NXU5	0.63
VPS37C	55048	A5D8V6	0.63
CEP55	55165	Q53EZ4	0.63
CEP126	57562	Q9P2H0	0.63
FBXO11	80204	Q86XK2	0.63
VOPP1	81552	Q96AW1	0.63
MAPK1IP1L	93487	Q8NDC0	0.63
GPRASP2	114928	Q96D09	0.63
LRRC15	131578	Q8TF66	0.63
RIPPLY2	134701	Q5TAB7	0.63
DSG4	147409	Q86SJ6	0.63
VSIG8	284677	Q5VU13	0.63
HEPHL1	341208	Q6MZM0	0.63
HNRNPCL1	343069	O60812	0.63
GBP7	388646	Q8N8V2	0.63
PEF1	553115	Q9UBV8	0.63
UMAD1	729852	C9J7I0	0.63
HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM	8329	P0C0S8	0.63
ANXA1	301	P04083	0.72
ATP6V1B2	526	P21281	0.72
ATP6V0A1	535	Q93050	0.72
CLTA	1211	P09496	0.72
FLOT2	2319	Q14254	0.72
RPL10A	4736	P62906	0.72
CHMP1A	5119	Q9HD42	0.72
RARS	5917	P54136	0.72
RPL4	6124	P36578	0.72
ITSN1	6453	Q15811	0.72
TOP2A	7153	P11388	0.72
SNX3	8724	O60493	0.72
AURKB	9212	Q96GD4	0.72
CLINT1	9685	Q14677	0.72
IST1	9798	P53990	0.72
URB1	9875	O60287	0.72
PDCD6IP	10015	Q8WUM4	0.72
RCL1	10171	Q9Y2P8	0.72
ATP5H	10476	O75947	0.72
MTUS2	23281	Q5JR59	0.72
NIPBL	25836	Q6KC79	0.72
NEPRO	25871	Q6NW34	0.72
FBXL6	26233	Q8N531	0.72
CHMP2A	27243	O43633	0.72
CHMP4A	29082	Q9BY43	0.72
PHF20	51230	Q9BVI0	0.72
CHMP5	51510	Q9NZZ3	0.72
SCLY	51540	Q96I15	0.72
CHMP3	51652	Q9Y3E7	0.72
DPM3	54344	Q9P2X0	0.72
DGCR8	54487	Q8WYQ5	0.72
NAT10	55226	Q9H0A0	0.72
CHMP1B	57132	Q7LBR1	0.72
ERGIC1	57222	Q969X5	0.72
BOLL	66037	Q8N9W6	0.72
BICC1	80114	Q9H694	0.72
KLHL13	90293	Q9P2N7	0.72
TOP1MT	116447	Q969P6	0.72
CHMP4B	128866	Q9H444	0.72
MITD1	129531	Q8WV92	0.72
PLBD2	196463	Q8NHP8	0.72
TRIM25	7706	Q14258	0.75
TFG	10342	Q92734	0.80
SEC31A	22872	O94979	0.82
GRB2	2885	P62993	0.86
PLSCR1	5359	O15162	0.87
FEN1	2237	P39748	0.49
TMEM17	200728	Q86X19	0.49
MED21	9412	Q13503	0.52
TSSK2	23617	Q96PF2	0.52
PTPN6	5777	P29350	0.62
ANXA11	311	P50995	0.63
CDK2	1017	P24941	0.63
CDK9	1025	P50750	0.63
CRMP1	1400	Q14194	0.63
CSTF2	1478	P33240	0.63
GBP2	2634	P32456	0.63
HNRNPF	3185	P52597	0.63
HSPA5	3309	P11021	0.63
IFI16	3428	Q16666	0.63
MCM2	4171	P49736	0.63
NEDD8	4738	Q15843	0.63
NTRK1	4914	P04629	0.63
PPP1CA	5499	P62136	0.63
MAPK13	5603	O15264	0.63
EIF2AK2	5610	P19525	0.63
RAD21	5885	O60216	0.63
SEC13	6396	P55735	0.63
STAT5B	6777	P51692	0.63
STK4	6789	Q13043	0.63
TRAF3	7187	Q13114	0.63
VRK1	7443	Q99986	0.63
CUL5	8065	Q93034	0.63
STK24	8428	Q9Y6E0	0.63
CUL4B	8450	Q13620	0.63
CUL4A	8451	Q13619	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
BRE	9577	Q9NXR7	0.63
GPRASP1	9737	Q5JY77	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
UBD	10537	O15205	0.63
COPS6	10980	Q7L5N1	0.63
COPS5	10987	Q92905	0.63
AKAP2	11217	Q9Y2D5	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
GABARAPL1	23710	Q9H0R8	0.63
BABAM1	29086	Q9NWV8	0.63
EEF2K	29904	O00418	0.63
STK26	51765	Q9P289	0.63
DCUN1D1	54165	Q96GG9	0.63
TRIM68	55128	Q6AZZ1	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
USE1	55850	Q9NZ43	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
MAP1LC3A	84557	Q9H492	0.63
UNK	85451	Q9C0B0	0.63
TP53RK	112858	Q96S44	0.63
EHBP1L1	254102	Q8N3D4	0.63
ASB18	401036	Q6ZVZ8	0.63
PIN1	5300	Q13526	0.68
CFTR	1080	P13569	0.72
MAP3K3	4215	Q99759	0.72
NFKB2	4791	Q00653	0.72
EWSR1	2130	Q01844	0.73
MAGED1	9500	Q9Y5V3	0.73
TSG101	7251	Q99816	0.82