PCOSBase

Protein Description

Gene Symbol	SAP18
Entrez ID	10284
Uniprot ID	O00422
Description	Sin3A associated protein 18kDa
Chromosomal Location	chr13: 21,140,514-21,149,084

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.	IDA\|IMP
BP	GO:0006351	transcription, DNA-templated	The cellular synthesis of RNA on a template of DNA.	IEA
BP	GO:0006357	regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	TAS
BP	GO:0006397	mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.	IEA
BP	GO:0008380	RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.	IEA
BP	GO:0016575	histone deacetylation	The modification of histones by removal of acetyl groups.	IEA
BP	GO:0043065	positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	IDA
BP	GO:0048025	negative regulation of mRNA splicing, via spliceosome	Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.	IDA
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription.	IEA
CC	GO:0000118	histone deacetylase complex	A protein complex that possesses histone deacetylase activity.	TAS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0016607	nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.	IDA
CC	GO:0035145	exon-exon junction complex	A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.	IDA
CC	GO:0061574	ASAP complex	A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.	IDA
MF	GO:0003714	transcription corepressor activity	Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.	TAS
MF	GO:0004407	histone deacetylase activity	Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.	TAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR010516	Sin3 associated polypeptide p18
IPR017250	Histone deacetylase complex, SAP18 subunit

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Pathway ID	Pathway Term	Pathway Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
WP47	Hedgehog Signaling Pathway	WikiPathways

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No diseases found.

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Tissue	Cell Type
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
endometrium	glandular cells
epididymis	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	neuronal cells
nasopharynx	respiratory epithelial cells
placenta	decidual cells
placenta	trophoblastic cells
testis	cells in seminiferous ducts
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
12734205	Wood et al.	2003	The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis
15598877	Wood et al.	2005	Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
MED19	219541	A0JLT2	0.00
SEPT7	989	Q16181	0.49
GTF3C1	2975	Q12789	0.49
SEPT2	4735	Q15019	0.49
PSAP	5660	P07602	0.49
SRSF1	6426	Q07955	0.49
SRSF3	6428	P84103	0.49
SRSF5	6430	Q13243	0.49
SRSF7	6432	Q16629	0.49
SMARCB1	6598	Q12824	0.49
SMARCC2	6601	Q8TAQ2	0.49
SNRPD2	6633	P62316	0.49
SSR3	6747	Q9UNL2	0.49
SURF4	6836	O15260	0.49
TFPI	7035	P10646	0.49
TPR	7175	P12270	0.49
U2AF1	7307	Q01081	0.49
VTN	7448	P04004	0.49
SMARCA5	8467	O60264	0.49
SART1	9092	O43290	0.49
SRSF11	9295	Q05519	0.49
THRAP3	9967	Q9Y2W1	0.49
SRSF10	10772	O75494	0.49
SUPT16H	11198	Q9Y5B9	0.49
U2AF2	11338	P26368	0.49
PHGDH	26227	O43175	0.49
TRA2A	29896	Q13595	0.49
SRRT	51593	Q9BXP5	0.49
SMU1	55234	Q2TAY7	0.49
WDR18	57418	Q9BV38	0.49
TRIM55	84675	Q9BYV6	0.49
SSRP1	6749	Q08945	0.59
DES	1674	P17661	0.63
FLNB	2317	O75369	0.63
GLS	2744	O94925	0.63
GSPT1	2935	P15170	0.63
DNAJA1	3301	P31689	0.63
HSPB1	3315	P04792	0.63
MAT2A	4144	P31153	0.63
CLPP	8192	Q16740	0.63
NUP93	9688	Q8N1F7	0.63
TADA3	10474	O75528	0.63
DDX19B	11269	Q9UMR2	0.63
SEPT6	23157	Q14141	0.63
MACF1	23499	Q9UPN3	0.63
ATXN10	25814	Q9UBB4	0.63
PCBP3	54039	P57721	0.63
DNAAF5	54919	Q86Y56	0.63
NCLN	56926	Q969V3	0.63
NOL12	79159	Q9UGY1	0.63
ARMC6	93436	Q6NXE6	0.63
INCA1	388324	Q0VD86	0.63
DDX3X	1654	O00571	0.72
SIN3A	25942	Q96ST3	0.75
DDOST	1650	P39656	0.76
EIF3E	3646	P60228	0.76
NSF	4905	P46459	0.76
RPN2	6185	P04844	0.76
YARS	8565	P54577	0.76
ATP5L	10632	O75964	0.76
KIF1BP	26128	Q96EK5	0.76
ARMT1	79624	Q9H993	0.76
POLE2	5427	P56282	0.78
RNPS1	10921	Q15287	0.79
ACIN1	22985	Q9UKV3	0.79
HDAC1	3065	Q13547	0.81
CDC5L	988	Q99459	0.49
HNRNPC	3183	P07910	0.49
HNRNPU	3192	Q00839	0.49
IK	3550	Q13123	0.49
MYO1C	4641	O00159	0.49
NFIA	4774	Q12857	0.49
SNU13	4809	P55769	0.49
S100A9	6280	P06702	0.49
SAFB	6294	Q15424	0.49
DDX21	9188	Q9NR30	0.49
NOLC1	9221	Q14978	0.49
MATR3	9782	P43243	0.49
RBM14	10432	Q96PK6	0.49
EBNA1BP2	10969	Q99848	0.49
PSIP1	11168	O75475	0.49
NCSTN	23385	Q92542	0.49
ADNP	23394	Q9H2P0	0.49
PRPF6	24148	O94906	0.49
PRPF40A	55660	O75400	0.49
LOC255308	255308	Q2VIR3	0.49
BMI1	648	P35226	0.63
CDK2	1017	P24941	0.63
EMD	2010	P50402	0.63
SFN	2810	P31947	0.63
GRK5	2869	P34947	0.63
IFI16	3428	Q16666	0.63
PNN	5411	Q9H307	0.63
RNF2	6045	Q99496	0.63
RPS3A	6189	P61247	0.63
VCP	7415	P55072	0.63
YWHAB	7529	P31946	0.63
YWHAG	7532	P61981	0.63
YWHAZ	7534	P63104	0.63
KIAA0101	9768	Q15004	0.63
SRRM1	10250	Q8IYB3	0.63
ZMYND11	10771	Q15326	0.63
GABARAPL2	11345	P60520	0.63
SUZ12	23512	Q15022	0.63
LUZP4	51213	Q9P127	0.63
DDX41	51428	Q9UJV9	0.63
IKZF1	10320	Q13422	0.65
CSNK2A2	1459	P19784	0.72
GLI1	2735	P08151	0.72
HNRNPD	3184	Q14103	0.72
MAGOH	4116	P61326	0.72
EPB41L3	23136	Q9Y2J2	0.72
CCDC22	28952	O60826	0.72
RNASEH2B	79621	Q5TBB1	0.72
SUMO2	6613	P61956	0.73
EIF4A3	9775	P38919	0.74
RGS10	6001	O43665	0.76
OSBPL10	114884	Q9BXB5	0.76
RBM39	9584	Q14498	0.89
SUFU	51684	Q9UMX1	0.92