Gene Symbol | NET1 |
Entrez ID | 10276 |
Uniprot ID | Q7Z628 |
Description | neuroepithelial cell transforming 1 |
Chromosomal Location | chr10: 5,412,551-5,458,463 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001558 |
regulation of cell growth |
Any process that modulates the frequency, rate, extent or direction of cell growth. |
NAS |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0035023 |
regulation of Rho protein signal transduction |
Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
IEA |
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IEA |
BP |
GO:0043065 |
positive regulation of apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
IDA|TAS |
BP |
GO:0043547 |
positive regulation of GTPase activity |
Any process that activates or increases the activity of a GTPase. |
IMP |
BP |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
TAS |
BP |
GO:0051451 |
myoblast migration |
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
IEA |
BP |
GO:0070301 |
cellular response to hydrogen peroxide |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
IDA |
BP |
GO:0071479 |
cellular response to ionizing radiation |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. |
IDA |
BP |
GO:1900026 |
positive regulation of substrate adhesion-dependent cell spreading |
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
MF |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
TAS |
MF |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
TAS |
MF |
GO:0017049 |
GTP-Rho binding |
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein. |
IEA |
Domain ID | Description |
---|---|
IPR000219 |
Dbl homology (DH) domain |
IPR001331 |
Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
IPR001849 |
Pleckstrin homology domain |
IPR011993 |
PH domain-like |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP2864 |
Apoptosis-related network due to altered Notch3 in ovarian cancer |
WikiPathways |
Tissue | Cell Type |
---|---|
heart muscle |
myocytes |
smooth muscle |
smooth muscle cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
DLG1 |
1739 |
Q12959 |
0.78 |
MAGI1 |
9223 |
Q96QZ7 |
0.94 |
RHOA |
387 |
P61586 |
0.63 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
EPAS1 |
2034 |
Q99814 |
0.63 |
WDR83 |
84292 |
Q9BRX9 |
0.63 |
PRKAB2 |
5565 |
O43741 |
0.72 |
USP11 |
8237 |
P51784 |
0.76 |