BP

GO:0000132

establishment of mitotic spindle orientation

A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.

IEA

BP

GO:0001656

metanephros development

The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.

IEA

BP

GO:0001657

ureteric bud development

The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.

IEA

BP

GO:0001759

organ induction

The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.

IEA

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IEA

BP

GO:0034260

negative regulation of GTPase activity

Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.

IEA

BP

GO:0040037

negative regulation of fibroblast growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.

IEA

BP

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.

TAS

BP

GO:0043407

negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

IEA

BP

GO:0046580

negative regulation of Ras protein signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.

IEA

BP

GO:0051387

negative regulation of neurotrophin TRK receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway.

IEA

BP

GO:0060449

bud elongation involved in lung branching

The process in which a bud in the lung grows out from the point where it is formed.

IEA

BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

ISS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

ISS|TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI