PCOSBase

Protein Description

Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006396	RNA processing	Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.	TAS
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IEA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0003677	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	TAS
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	TAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

Domain ID	Description
IPR000467	G-patch domain
IPR000504	RNA recognition motif domain
IPR028806	RNA-binding protein 6
IPR034123	RBM6, RNA recognition motif 1
IPR034125	RBM6, RNA recognition motif 2

Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
cerebellum	cells in molecular layer
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
kidney	cells in glomeruli
kidney	cells in tubules
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome
26459919	Lan et al.	2015	Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol	Entrez ID	Uniprot ID	Score
SF3B3	23450	Q15393	0.63
FOS	2353	P01100	0.49
EEF1G	1937	P26641	0.63
FGL1	2267	Q08830	0.63
SHMT2	6472	P34897	0.63
TAF7	6879	Q15545	0.63
NXF1	10482	Q9UBU9	0.63
SIRT7	51547	Q9NRC8	0.63
PAPD5	64282	Q8NDF8	0.63
ASB12	142689	Q8WXK4	0.63
ASB18	401036	Q6ZVZ8	0.63
HNRNPA1	3178	P09651	0.72
PPP1CB	5500	P62140	0.72
EMC2	9694	Q15006	0.72
MATR3	9782	P43243	0.72
MMGT1	93380	Q8N4V1	0.72
SUMO2	6613	P61956	0.73