Gene Symbol | CHST4 |
Entrez ID | 10164 |
Uniprot ID | Q8NCG5 |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 |
Chromosomal Location | chr16: 71,525,233-71,538,746 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006044 |
N-acetylglucosamine metabolic process |
The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. |
IDA |
BP |
GO:0006477 |
protein sulfation |
The addition of a sulfate group as an ester to a protein amino acid. |
TAS |
BP |
GO:0006790 |
sulfur compound metabolic process |
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. |
IDA |
BP |
GO:0006928 |
movement of cell or subcellular component |
The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. |
TAS |
BP |
GO:0006954 |
inflammatory response |
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
IEA |
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
TAS |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
TAS |
BP |
GO:0007267 |
cell-cell signaling |
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
TAS |
BP |
GO:0016266 |
O-glycan processing |
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. |
TAS |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0005802 |
trans-Golgi network |
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
IDA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IBA |
CC |
GO:0031228 |
intrinsic component of Golgi membrane |
The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
NAS |
MF |
GO:0001517 |
N-acetylglucosamine 6-O-sulfotransferase activity |
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. |
IDA|TAS |
MF |
GO:0008146 |
sulfotransferase activity |
Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. |
TAS |
Domain ID | Description |
---|---|
IPR000863 |
Sulfotransferase domain |
IPR016469 |
Carbohydrate sulfotransferase |
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00533 |
Glycosaminoglycan biosynthesis - keratan sulfate |
KEGG |
WP702 |
Metapathway biotransformation |
WikiPathways |
Tissue | Cell Type |
---|---|
gallbladder |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CD34 |
947 |
P28906 |
0.52 |
DCPS |
28960 |
Q96C86 |
0.63 |