| Gene Symbol | SH2B3 |
| Entrez ID | 10019 |
| Uniprot ID | Q9UQQ2 |
| Description | SH2B adaptor protein 3 |
| Chromosomal Location | chr12: 111,405,948-111,451,623 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0007596 |
blood coagulation |
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. |
TAS |
|
BP |
GO:0009967 |
positive regulation of signal transduction |
Any process that activates or increases the frequency, rate or extent of signal transduction. |
IEA |
|
BP |
GO:0030154 |
cell differentiation |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
IEA |
|
BP |
GO:0035162 |
embryonic hemopoiesis |
The stages of blood cell formation that take place within the embryo. |
IEA |
|
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IEA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0004871 |
signal transducer activity |
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
IEA |
|
MF |
GO:0035591 |
signaling adaptor activity |
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000980 |
SH2 domain |
|
IPR001849 |
Pleckstrin homology domain |
|
IPR011993 |
PH domain-like |
|
IPR015012 |
Phenylalanine zipper |
|
IPR030522 |
SH2B adapter protein 3 |
|
IPR030523 |
SH2B adapter protein |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04722 |
Neurotrophin signaling pathway |
KEGG |
|
WP3945 |
TYROBP Causal Network |
WikiPathways |
|
WP69 |
T-Cell antigen Receptor (TCR) Signaling Pathway |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0001815 |
Primary Myelofibrosis |
|
C0007570 |
Celiac Disease |
|
C0011854 |
Diabetes Mellitus, Insulin-Dependent |
|
C0020676 |
Hypothyroidism |
|
C0021368 |
Inflammation |
|
C0024141 |
Lupus Erythematosus, Systemic |
|
C0027051 |
Myocardial Infarction |
|
C0040028 |
Thrombocythemia, Essential |
|
C0042900 |
Vitiligo |
|
C0349639 |
Juvenile Myelomonocytic Leukemia |
|
C1956346 |
Coronary Artery Disease |
| Tissue | Cell Type |
|---|---|
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
colon |
endothelial cells |
|
colon |
peripheral nerve/ganglion |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SRC |
6714 |
P12931 |
0.00 |
|
SOCS3 |
9021 |
O14543 |
0.00 |
|
SH2B3 |
10019 |
Q9UQQ2 |
0.55 |
|
CD247 |
919 |
P20963 |
0.62 |
|
EGFR |
1956 |
P00533 |
0.63 |
|
ERBB2 |
2064 |
P04626 |
0.63 |
|
ERBB3 |
2065 |
P21860 |
0.63 |
|
MET |
4233 |
P08581 |
0.72 |
|
PLCG1 |
5335 |
P19174 |
0.72 |
|
FLNA |
2316 |
P21333 |
0.77 |
|
GRB2 |
2885 |
P62993 |
0.85 |
|
KIT |
3815 |
P10721 |
0.89 |
|
ZAP70 |
7535 |
P43403 |
0.52 |
|
HAVCR2 |
84868 |
Q8TDQ0 |
0.56 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
TNS2 |
23371 |
Q63HR2 |
0.63 |
|
LCK |
3932 |
P06239 |
0.85 |