Protein Description

Gene Symbol ENTPD6
Entrez ID 955
Uniprot ID O75354
Description ectonucleoside triphosphate diphosphohydrolase 6 (putative)
Chromosomal Location chr20: 25,195,693-25,226,729
Ontology GO ID GO Term Definition Evidence

BP

GO:0032026

response to magnesium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.

IEA

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IEA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0008894

guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity

Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate.

IEA

MF

GO:0017111

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

IEA

MF

GO:0045134

uridine-diphosphatase activity

Catalysis of the reaction: UDP + H2O = UMP + phosphate.

IEA

Domain ID Description

IPR000407

Nucleoside phosphatase GDA1/CD39

Pathway ID Pathway Term Pathway Source

hsa00230

Purine metabolism

KEGG

hsa00240

Pyrimidine metabolism

KEGG

UMLS CUI UMLS Term

C0036631

Seminoma

C2607914

Allergic Rhinitis (Disorder)

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

breast

glandular cells

bronchus

respiratory epithelial cells

cerebellum

Purkinje cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

rectum

glandular cells

skin

Langerhans

skin

epidermal cells

small intestine

glandular cells

spleen

cells in red pulp

spleen

cells in white pulp

testis

Leydig cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATXN1

6310

P54253

0.63

GSK3B

2932

P49841

0.63

PON2

5445

Q15165

0.63

NAAA

27163

Q02083

0.63

SIAE

54414

Q9HAT2

0.63

SUSD4

55061

Q5VX71

0.63

TMEM25

84866

Q86YD3

0.63

CANT1

124583

Q8WVQ1

0.63

HTR3C

170572

Q8WXA8

0.63

RAB5A

5868

P20339

0.72

RACGAP1

29127

Q9H0H5

0.72