| Gene Symbol | AKT3 |
| Entrez ID | 10000 |
| Uniprot ID | Q9Y243 |
| Description | v-akt murine thymoma viral oncogene homolog 3 |
| Chromosomal Location | chr1: 243,488,233-243,851,079 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000002 |
mitochondrial genome maintenance |
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. |
IMP |
|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
TAS |
|
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
IMP |
|
BP |
GO:0018105 |
peptidyl-serine phosphorylation |
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
IBA |
|
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IBA |
|
CC |
GO:0005622 |
intracellular |
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. |
IBA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IDA |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
|
MF |
GO:0004672 |
protein kinase activity |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
TAS |
|
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000719 |
Protein kinase domain |
|
IPR000961 |
AGC-kinase, C-terminal |
|
IPR001849 |
Pleckstrin homology domain |
|
IPR008271 |
Serine/threonine-protein kinase, active site |
|
IPR011009 |
Protein kinase-like domain |
|
IPR011993 |
PH domain-like |
|
IPR017441 |
Protein kinase, ATP binding site |
|
IPR017892 |
Protein kinase, C-terminal |
|
IPR034675 |
Protein kinase B gamma, catalytic domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa01521 |
EGFR tyrosine kinase inhibitor resistance |
KEGG |
|
hsa01522 |
Endocrine resistance |
KEGG |
|
hsa01524 |
Platinum drug resistance |
KEGG |
|
hsa04010 |
MAPK signaling pathway |
KEGG |
|
hsa04012 |
ErbB signaling pathway |
KEGG |
|
hsa04014 |
Ras signaling pathway |
KEGG |
|
hsa04015 |
Rap1 signaling pathway |
KEGG |
|
hsa04022 |
cGMP-PKG signaling pathway |
KEGG |
|
hsa04024 |
cAMP signaling pathway |
KEGG |
|
hsa04062 |
Chemokine signaling pathway |
KEGG |
|
hsa04066 |
HIF-1 signaling pathway |
KEGG |
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04071 |
Sphingolipid signaling pathway |
KEGG |
|
hsa04072 |
Phospholipase D signaling pathway |
KEGG |
|
hsa04140 |
Autophagy - animal |
KEGG |
|
hsa04150 |
mTOR signaling pathway |
KEGG |
|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
|
hsa04152 |
AMPK signaling pathway |
KEGG |
|
hsa04210 |
Apoptosis |
KEGG |
|
hsa04211 |
Longevity regulating pathway |
KEGG |
|
hsa04213 |
Longevity regulating pathway - multiple species |
KEGG |
|
hsa04261 |
Adrenergic signaling in cardiomyocytes |
KEGG |
|
hsa04370 |
VEGF signaling pathway |
KEGG |
|
hsa04371 |
Apelin signaling pathway |
KEGG |
|
hsa04380 |
Osteoclast differentiation |
KEGG |
|
hsa04510 |
Focal adhesion |
KEGG |
|
hsa04550 |
Signaling pathways regulating pluripotency of stem cells |
KEGG |
|
hsa04611 |
Platelet activation |
KEGG |
|
hsa04620 |
Toll-like receptor signaling pathway |
KEGG |
|
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
|
hsa04660 |
T cell receptor signaling pathway |
KEGG |
|
hsa04662 |
B cell receptor signaling pathway |
KEGG |
|
hsa04664 |
Fc epsilon RI signaling pathway |
KEGG |
|
hsa04666 |
Fc gamma R-mediated phagocytosis |
KEGG |
|
hsa04668 |
TNF signaling pathway |
KEGG |
|
hsa04722 |
Neurotrophin signaling pathway |
KEGG |
|
hsa04725 |
Cholinergic synapse |
KEGG |
|
hsa04728 |
Dopaminergic synapse |
KEGG |
|
hsa04910 |
Insulin signaling pathway |
KEGG |
|
hsa04914 |
Progesterone-mediated oocyte maturation |
KEGG |
|
hsa04915 |
Estrogen signaling pathway |
KEGG |
|
hsa04917 |
Prolactin signaling pathway |
KEGG |
|
hsa04919 |
Thyroid hormone signaling pathway |
KEGG |
|
hsa04920 |
Adipocytokine signaling pathway |
KEGG |
|
hsa04922 |
Glucagon signaling pathway |
KEGG |
|
hsa04923 |
Regulation of lipolysis in adipocytes |
KEGG |
|
hsa04931 |
Insulin resistance |
KEGG |
|
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
|
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
|
hsa04973 |
Carbohydrate digestion and absorption |
KEGG |
|
hsa05142 |
Chagas disease (American trypanosomiasis) |
KEGG |
|
hsa05145 |
Toxoplasmosis |
KEGG |
|
hsa05152 |
Tuberculosis |
KEGG |
|
hsa05160 |
Hepatitis C |
KEGG |
|
hsa05161 |
Hepatitis B |
KEGG |
|
hsa05162 |
Measles |
KEGG |
|
hsa05164 |
Influenza A |
KEGG |
|
hsa05166 |
HTLV-I infection |
KEGG |
|
hsa05169 |
Epstein-Barr virus infection |
KEGG |
|
hsa05200 |
Pathways in cancer |
KEGG |
|
hsa05205 |
Proteoglycans in cancer |
KEGG |
|
hsa05210 |
Colorectal cancer |
KEGG |
|
hsa05211 |
Renal cell carcinoma |
KEGG |
|
hsa05212 |
Pancreatic cancer |
KEGG |
|
hsa05213 |
Endometrial cancer |
KEGG |
|
hsa05214 |
Glioma |
KEGG |
|
hsa05215 |
Prostate cancer |
KEGG |
|
hsa05218 |
Melanoma |
KEGG |
|
hsa05220 |
Chronic myeloid leukemia |
KEGG |
|
hsa05221 |
Acute myeloid leukemia |
KEGG |
|
hsa05222 |
Small cell lung cancer |
KEGG |
|
hsa05223 |
Non-small cell lung cancer |
KEGG |
|
hsa05224 |
Breast cancer |
KEGG |
|
hsa05230 |
Central carbon metabolism in cancer |
KEGG |
|
hsa05231 |
Choline metabolism in cancer |
KEGG |
|
hsa05418 |
Fluid shear stress and atherosclerosis |
KEGG |
|
WP26 |
Signal Transduction of S1P Receptor |
WikiPathways |
|
WP3929 |
Chemokine signaling pathway |
WikiPathways |
|
WP306 |
Focal Adhesion |
WikiPathways |
|
WP75 |
Toll-like Receptor Signaling Pathway |
WikiPathways |
|
WP3287 |
Overview of nanoparticle effects |
WikiPathways |
|
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
|
WP3931 |
ESC Pluripotency Pathways |
WikiPathways |
|
WP1449 |
Regulation of toll-like receptor signaling pathway |
WikiPathways |
|
WP2643 |
Nanoparticle-mediated activation of receptor signaling |
WikiPathways |
|
WP185 |
Integrin-mediated Cell Adhesion |
WikiPathways |
|
WP382 |
MAPK Signaling Pathway |
WikiPathways |
|
WP2261 |
Signaling Pathways in Glioblastoma |
WikiPathways |
|
WP673 |
ErbB Signaling Pathway |
WikiPathways |
|
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0036341 |
Schizophrenia |
|
C0431391 |
Hemimegalencephaly |
|
C1955869 |
Malformations Of Cortical Development |
| Tissue | Cell Type |
|---|---|
|
caudate |
neuronal cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
placenta |
decidual cells |
|
thyroid gland |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CASP9 |
842 |
P55211 |
0.00 |
|
CDKN1A |
1026 |
P38936 |
0.00 |
|
CDKN1B |
1027 |
P46527 |
0.00 |
|
FLT1 |
2321 |
P17948 |
0.00 |
|
GNAO1 |
2775 |
P09471 |
0.00 |
|
GNAZ |
2781 |
P19086 |
0.00 |
|
IKBKB |
3551 |
O14920 |
0.00 |
|
ILK |
3611 |
Q13418 |
0.00 |
|
NFKB1 |
4790 |
P19838 |
0.00 |
|
NFKBIA |
4792 |
P25963 |
0.00 |
|
NFKBIB |
4793 |
Q15653 |
0.00 |
|
NFKBIE |
4794 |
O00221 |
0.00 |
|
PDE3A |
5139 |
Q14432 |
0.00 |
|
PDE3B |
5140 |
Q13370 |
0.00 |
|
PDK1 |
5163 |
Q15118 |
0.00 |
|
PIK3CA |
5290 |
P42336 |
0.00 |
|
PIK3CB |
5291 |
P42338 |
0.00 |
|
PIK3CD |
5293 |
O00329 |
0.00 |
|
PIK3CG |
5294 |
P48736 |
0.00 |
|
PIK3R1 |
5295 |
P27986 |
0.00 |
|
PIK3R2 |
5296 |
O00459 |
0.00 |
|
RELA |
5970 |
Q04206 |
0.00 |
|
SLC2A4 |
6517 |
P14672 |
0.00 |
|
SOS1 |
6654 |
Q07889 |
0.00 |
|
PIK3R3 |
8503 |
Q92569 |
0.00 |
|
IKBKG |
8517 |
Q9Y6K9 |
0.00 |
|
EIF4EBP1 |
1978 |
Q13541 |
0.49 |
|
RPE |
6120 |
Q96AT9 |
0.49 |
|
NUDCD1 |
84955 |
Q96RS6 |
0.49 |
|
GSK3B |
2932 |
P49841 |
0.52 |
|
ARRB2 |
409 |
P32121 |
0.63 |
|
GTF3C1 |
2975 |
Q12789 |
0.63 |
|
HCLS1 |
3059 |
P14317 |
0.63 |
|
HNRNPA2B1 |
3181 |
P22626 |
0.63 |
|
IARS |
3376 |
P41252 |
0.63 |
|
LAMC1 |
3915 |
P11047 |
0.63 |
|
RPS27 |
6232 |
P42677 |
0.63 |
|
TTC3 |
7267 |
P53804 |
0.63 |
|
UBE2E1 |
7324 |
P51965 |
0.63 |
|
CSDE1 |
7812 |
O75534 |
0.63 |
|
CLIP3 |
25999 |
Q96DZ5 |
0.63 |
|
PLEKHO1 |
51177 |
Q53GL0 |
0.63 |
|
PRPF40A |
55660 |
O75400 |
0.63 |
|
ZNF527 |
84503 |
Q8NB42 |
0.63 |
|
UNC13C |
440279 |
Q8NB66 |
0.63 |
|
PKM |
5315 |
P14618 |
0.68 |
|
TCL1A |
8115 |
P56279 |
0.74 |
|
HSP90AA1 |
3320 |
P07900 |
0.49 |
|
NEDD4L |
23327 |
Q96PU5 |
0.52 |
|
PRKCD |
5580 |
Q05655 |
0.55 |
|
TSC2 |
7249 |
P49815 |
0.55 |
|
NEDD4 |
4734 |
P46934 |
0.59 |
|
MXRA5 |
25878 |
Q9NR99 |
0.63 |
|
ZNF354C |
30832 |
Q86Y25 |
0.63 |
|
SPOCK3 |
50859 |
Q9BQ16 |
0.63 |
|
MAL2 |
114569 |
Q969L2 |
0.63 |
|
CASP3 |
836 |
P42574 |
0.65 |
|
PDPK1 |
5170 |
O15530 |
0.65 |
|
CDC37 |
11140 |
Q16543 |
0.73 |
|
PRKCZ |
5590 |
Q05513 |
0.89 |