| Gene Symbol | G3BP2 |
| Entrez ID | 9908 |
| Uniprot ID | Q9UN86 |
| Description | GTPase activating protein (SH3 domain) binding protein 2 |
| Chromosomal Location | chr4: 75,642,782-75,724,525 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0007253 |
cytoplasmic sequestering of NF-kappaB |
The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. |
NAS |
|
BP |
GO:0007265 |
Ras protein signal transduction |
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
NAS |
|
BP |
GO:0051028 |
mRNA transport |
The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA|NAS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA |
|
CC |
GO:0030529 |
intracellular ribonucleoprotein complex |
An intracellular macromolecular complex containing both protein and RNA molecules. |
IBA |
|
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
|
MF |
GO:0003729 |
mRNA binding |
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
IBA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0030159 |
receptor signaling complex scaffold activity |
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex. |
NAS |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000504 |
RNA recognition motif domain |
|
IPR002075 |
Nuclear transport factor 2 |
|
IPR018222 |
Nuclear transport factor 2, eukaryote |
|
IPR032710 |
NTF2-like domain |
|
IPR034376 |
G3BP2, RNA recognition motif |
|
IPR034377 |
Ras GTPase-activating protein-binding protein 2 |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ADSL |
158 |
P30566 |
0.49 |
|
NFKB1 |
4790 |
P19838 |
0.55 |
|
ABL1 |
25 |
P00519 |
0.63 |
|
NUP88 |
4927 |
Q99567 |
0.63 |
|
POM121 |
9883 |
Q96HA1 |
0.63 |
|
NUP153 |
9972 |
P49790 |
0.63 |
|
G3BP1 |
10146 |
Q13283 |
0.63 |
|
ASCC3 |
10973 |
Q8N3C0 |
0.72 |
|
RPF2 |
84154 |
Q9H7B2 |
0.72 |
|
DDX10 |
1662 |
Q13206 |
0.76 |
|
RNH1 |
6050 |
P13489 |
0.76 |
|
RPL3L |
6123 |
Q92901 |
0.76 |
|
FARS2 |
10667 |
O95363 |
0.76 |
|
NEPRO |
25871 |
Q6NW34 |
0.76 |
|
GNL2 |
29889 |
Q13823 |
0.76 |
|
UIMC1 |
51720 |
Q96RL1 |
0.76 |
|
UBAP2 |
55833 |
Q5T6F2 |
0.76 |
|
DDX24 |
57062 |
Q9GZR7 |
0.76 |
|
WDR36 |
134430 |
Q8NI36 |
0.76 |
|
RPL22L1 |
200916 |
Q6P5R6 |
0.76 |
|
NUP214 |
8021 |
P35658 |
0.86 |
|
ATXN2L |
11273 |
Q8WWM7 |
0.86 |
|
NUP62 |
23636 |
P37198 |
0.86 |
|
NUFIP2 |
57532 |
Q7Z417 |
0.86 |
|
NFKBIA |
4792 |
P25963 |
0.88 |
|
USP10 |
9100 |
Q14694 |
0.89 |
|
YARS |
8565 |
P54577 |
0.49 |
|
PABPC4 |
8761 |
Q13310 |
0.49 |
|
IFI30 |
10437 |
P13284 |
0.49 |
|
PRPF8 |
10594 |
Q6P2Q9 |
0.49 |
|
IGF2BP3 |
10643 |
O00425 |
0.49 |
|
PABPC1 |
26986 |
P11940 |
0.49 |
|
BMI1 |
648 |
P35226 |
0.63 |
|
CA9 |
768 |
Q16790 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
DDX6 |
1656 |
P26196 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
SFN |
2810 |
P31947 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
NEDD8 |
4738 |
Q15843 |
0.63 |
|
YBX1 |
4904 |
P67809 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PTEN |
5728 |
P60484 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RPS6KA1 |
6195 |
Q15418 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
TERF2 |
7014 |
Q15554 |
0.63 |
|
VCP |
7415 |
P55072 |
0.63 |
|
YWHAZ |
7534 |
P63104 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
FXR2 |
9513 |
P51116 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
EIF1B |
10289 |
O60739 |
0.63 |
|
IVNS1ABP |
10625 |
Q9Y6Y0 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
SUZ12 |
23512 |
Q15022 |
0.63 |
|
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.68 |
|
PIN1 |
5300 |
Q13526 |
0.68 |
|
TP53 |
7157 |
P04637 |
0.68 |
|
ARRB2 |
409 |
P32121 |
0.72 |
|
RPL10 |
6134 |
P27635 |
0.72 |
|
STK24 |
8428 |
Q9Y6E0 |
0.76 |
|
ING4 |
51147 |
Q9UNL4 |
0.76 |