PCOSBase

Protein Description

Gene Symbol	G3BP2
Entrez ID	9908
Uniprot ID	Q9UN86
Description	GTPase activating protein (SH3 domain) binding protein 2
Chromosomal Location	chr4: 75,642,782-75,724,525

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0007253	cytoplasmic sequestering of NF-kappaB	The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.	NAS
BP	GO:0007265	Ras protein signal transduction	A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.	NAS
BP	GO:0051028	mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.	IEA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA\|NAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IBA
CC	GO:0030529	intracellular ribonucleoprotein complex	An intracellular macromolecular complex containing both protein and RNA molecules.	IBA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0003729	mRNA binding	Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.	IBA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0030159	receptor signaling complex scaffold activity	Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.	NAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000504	RNA recognition motif domain
IPR002075	Nuclear transport factor 2
IPR018222	Nuclear transport factor 2, eukaryote
IPR032710	NTF2-like domain
IPR034376	G3BP2, RNA recognition motif
IPR034377	Ras GTPase-activating protein-binding protein 2

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No pathways found.

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
lung	macrophages
lymph node	germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
small intestine	glandular cells
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
ADSL	158	P30566	0.49
NFKB1	4790	P19838	0.55
ABL1	25	P00519	0.63
NUP88	4927	Q99567	0.63
POM121	9883	Q96HA1	0.63
NUP153	9972	P49790	0.63
G3BP1	10146	Q13283	0.63
ASCC3	10973	Q8N3C0	0.72
RPF2	84154	Q9H7B2	0.72
DDX10	1662	Q13206	0.76
RNH1	6050	P13489	0.76
RPL3L	6123	Q92901	0.76
FARS2	10667	O95363	0.76
NEPRO	25871	Q6NW34	0.76
GNL2	29889	Q13823	0.76
UIMC1	51720	Q96RL1	0.76
UBAP2	55833	Q5T6F2	0.76
DDX24	57062	Q9GZR7	0.76
WDR36	134430	Q8NI36	0.76
RPL22L1	200916	Q6P5R6	0.76
NUP214	8021	P35658	0.86
ATXN2L	11273	Q8WWM7	0.86
NUP62	23636	P37198	0.86
NUFIP2	57532	Q7Z417	0.86
NFKBIA	4792	P25963	0.88
USP10	9100	Q14694	0.89
YARS	8565	P54577	0.49
PABPC4	8761	Q13310	0.49
IFI30	10437	P13284	0.49
PRPF8	10594	Q6P2Q9	0.49
IGF2BP3	10643	O00425	0.49
PABPC1	26986	P11940	0.49
BMI1	648	P35226	0.63
CA9	768	Q16790	0.63
CDK2	1017	P24941	0.63
DDX6	1656	P26196	0.63
ELAVL1	1994	Q15717	0.63
ESR1	2099	P03372	0.63
SFN	2810	P31947	0.63
HNRNPA1	3178	P09651	0.63
JUN	3725	P05412	0.63
NEDD8	4738	Q15843	0.63
YBX1	4904	P67809	0.63
NTRK1	4914	P04629	0.63
PTEN	5728	P60484	0.63
RNF2	6045	Q99496	0.63
RPS6KA1	6195	Q15418	0.63
SUMO2	6613	P61956	0.63
TERF2	7014	Q15554	0.63
VCP	7415	P55072	0.63
YWHAZ	7534	P63104	0.63
CUL3	8452	Q13618	0.63
CUL1	8454	Q13616	0.63
FXR2	9513	P51116	0.63
KIAA0101	9768	Q15004	0.63
EIF1B	10289	O60739	0.63
IVNS1ABP	10625	Q9Y6Y0	0.63
COPS5	10987	Q92905	0.63
GABARAPL2	11345	P60520	0.63
SNW1	22938	Q13573	0.63
TARDBP	23435	Q13148	0.63
SUZ12	23512	Q15022	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
MDM2	4193	Q00987	0.68
PIN1	5300	Q13526	0.68
TP53	7157	P04637	0.68
ARRB2	409	P32121	0.72
RPL10	6134	P27635	0.72
STK24	8428	Q9Y6E0	0.76
ING4	51147	Q9UNL4	0.76