| Gene Symbol | TLK1 |
| Entrez ID | 9874 |
| Uniprot ID | Q9UKI8 |
| Description | tousled like kinase 1 |
| Chromosomal Location | chr2: 170,990,823-171,231,314 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001672 |
regulation of chromatin assembly or disassembly |
Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly. |
IDA |
|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
IDA |
|
BP |
GO:0006886 |
intracellular protein transport |
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
IDA |
|
BP |
GO:0006974 |
cellular response to DNA damage stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
IEA |
|
BP |
GO:0007049 |
cell cycle |
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
IEA |
|
BP |
GO:0016569 |
chromatin modification |
The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. |
IEA |
|
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IDA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA|TAS |
|
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA|TAS |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000719 |
Protein kinase domain |
|
IPR008271 |
Serine/threonine-protein kinase, active site |
|
IPR011009 |
Protein kinase-like domain |
|
IPR017441 |
Protein kinase, ATP binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP707 |
DNA Damage Response |
WikiPathways |
|
WP2516 |
ATM Signaling Pathway |
WikiPathways |
|
WP1530 |
miRNA Regulation of DNA Damage Response |
WikiPathways |
|
WP3651 |
Pathways Affected in Adenoid Cystic Carcinoma |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0010606 |
Adenoid Cystic Carcinoma |
|
C0017661 |
Iga Glomerulonephritis |
|
C0027643 |
Neoplasm Recurrence, Local |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
breast |
adipocytes |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
adipocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
XPO7 |
23039 |
Q9UIA9 |
0.49 |
|
HIST1H1A |
3024 |
Q02539 |
0.52 |
|
NBN |
4683 |
O60934 |
0.52 |
|
SNAP23 |
8773 |
O00161 |
0.58 |
|
SHC1 |
6464 |
P29353 |
0.63 |
|
LUZP4 |
51213 |
Q9P127 |
0.63 |
|
MBP |
4155 |
P02686 |
0.65 |
|
TLK2 |
11011 |
Q86UE8 |
0.73 |
|
TLK1 |
9874 |
Q9UKI8 |
0.84 |
|
INPP1 |
3628 |
P49441 |
0.49 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
TPM3 |
7170 |
P06753 |
0.63 |
|
YWHAE |
7531 |
P62258 |
0.63 |
|
UBE3C |
9690 |
Q15386 |
0.63 |
|
AURKA |
6790 |
O14965 |
0.65 |
|
CHEK1 |
1111 |
O14757 |
0.68 |
|
DYNLL1 |
8655 |
P63167 |
0.72 |
|
ASF1A |
25842 |
Q9Y294 |
0.86 |
|
ASF1B |
55723 |
Q9NVP2 |
0.89 |