PCOSBase

Protein Description

Gene Symbol	CEP170
Entrez ID	9859
Uniprot ID	Q5SW79
Description	centrosomal protein 170kDa
Chromosomal Location	chr1: 243,124,428-243,255,348

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Ontology	GO ID	GO Term	Definition	Evidence
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005813	centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.	IDA
CC	GO:0005814	centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.	IDA
CC	GO:0005819	spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.	IEA
CC	GO:0005874	microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.	IEA
CC	GO:0031965	nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.	IDA

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Domain ID	Description
IPR000253	Forkhead-associated (FHA) domain
IPR008984	SMAD/FHA domain
IPR026644	Centrosomal protein of 170kDa
IPR029300	CEP170, C-terminal

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No pathways found.

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No diseases found.

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Tissue	Cell Type
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
colon	endothelial cells
colon	peripheral nerve/ganglion
endometrium	cells in endometrial stroma
endometrium	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
kidney	cells in glomeruli
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
soft tissue	chondrocytes
spleen	cells in red pulp
testis	cells in seminiferous ducts
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
23824412	Piltonen et al.	2013	Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

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Gene Symbol	Entrez ID	Uniprot ID	Score
ZC2HC1A	51101	Q96GY0	0.49
XIAP	331	P98170	0.49
ARRB2	409	P32121	0.49
CAMK2D	817	Q13557	0.49
CBL	867	P22681	0.49
CCNB1	891	P14635	0.49
CRKL	1399	P46109	0.49
CSNK2A2	1459	P19784	0.49
DCTN1	1639	Q14203	0.49
DRG2	1819	P55039	0.49
GPX4	2879	P36969	0.49
GRB2	2885	P62993	0.49
HMMR	3161	O75330	0.49
AGFG1	3267	P52594	0.49
HSPA1A	3303	P0DMV8	0.49
HSPA1B	3304	P0DMV9	0.49
LASP1	3927	Q14847	0.49
MTAP	4507	Q13126	0.49
NARS	4677	O43776	0.49
NCK1	4690	P16333	0.49
OCRL	4952	Q01968	0.49
UPF1	5976	Q92900	0.49
RRM2	6241	P31350	0.49
SDCBP	6386	O00560	0.49
SHC1	6464	P29353	0.49
TRIP6	7205	Q15654	0.49
TTK	7272	P33981	0.49
YWHAH	7533	Q04917	0.49
LUZP1	7798	Q86V48	0.49
NCK2	8440	O43639	0.49
PEA15	8682	Q15121	0.49
LIMD1	8994	Q9UGP4	0.49
MTMR6	9107	Q9Y217	0.49
TMSB10	9168	P63313	0.49
ARHGEF2	9181	Q92974	0.49
DCLK1	9201	O15075	0.49
SNX17	9784	Q15036	0.49
ACTR2	10097	P61160	0.49
TXNDC9	10190	O14530	0.49
NEBL	10529	O76041	0.49
SUGT1	10910	Q9Y2Z0	0.49
ASCC3	10973	Q8N3C0	0.49
CEP131	22994	Q9UPN4	0.49
CKAP2	26586	Q8WWK9	0.49
NME7	29922	Q9Y5B8	0.49
WRAP73	49856	Q9P2S5	0.49
GTSE1	51512	Q9NYZ3	0.49
HAUS6	54801	Q7Z4H7	0.49
CC2D1A	54862	Q6P1N0	0.49
MAP7D1	55700	Q3KQU3	0.49
NECAP2	55707	Q9NVZ3	0.49
UNC45A	55898	Q9H3U1	0.49
KLHL9	55958	Q9P2J3	0.49
GOPC	57120	Q9HD26	0.49
SLAIN2	57606	Q9P270	0.49
HS1BP3	64342	Q53T59	0.49
SMAP2	64744	Q8WU79	0.49
HAUS3	79441	Q68CZ6	0.49
MAP7D3	79649	Q8IWC1	0.49
IFT74	80173	Q96LB3	0.49
SETD7	80854	Q8WTS6	0.49
FAM83D	81610	Q9H4H8	0.49
TCHP	84260	Q9BT92	0.49
CCDC77	84318	Q9BR77	0.49
HAUS8	93323	Q9BT25	0.49
NEDD1	121441	Q8NHV4	0.49
PPP1R21	129285	Q6ZMI0	0.49
MTPN	136319	P58546	0.49
MB21D2	151963	Q8IYB1	0.49
CAMSAP1	157922	Q5T5Y3	0.49
CCDC138	165055	Q96M89	0.49
FAAP20	199990	Q6NZ36	0.49
SKA1	220134	Q96BD8	0.49
SKA3	221150	Q8IX90	0.49
DAPK3	1613	O43293	0.63
PCYT1A	5130	P49585	0.63
PKD2	5311	Q13563	0.63
CCDC6	8030	Q16204	0.63
TNKS	8658	O95271	0.63
VAMP8	8673	Q9BV40	0.63
STX8	9482	Q9UNK0	0.63
PDE4DIP	9659	Q5VU43	0.63
AKAP9	10142	Q99996	0.63
VTI1B	10490	Q9UEU0	0.63
GCN1	10985	Q92616	0.63
CEP250	11190	Q9BV73	0.63
SYNE2	23224	Q8WXH0	0.63
DSTYK	25778	Q6XUX3	0.63
RFWD3	55159	Q6PCD5	0.63
PSPC1	55269	Q8WXF1	0.63
RUFY2	55680	Q8WXA3	0.63
CORO1B	57175	Q9BR76	0.63
BEGAIN	57596	Q9BUH8	0.63
KNSTRN	90417	Q9Y448	0.63
STX1B	112755	P61266	0.63
ASB7	140460	Q9H672	0.63
NHSL2	340527	Q5HYW2	0.63
SPAG5	10615	Q96R06	0.73
DISC1	27185	Q9NRI5	0.73
NIN	51199	Q8N4C6	0.73
MIS18A	54069	Q9NYP9	0.73
CEP170B	283638	Q9Y4F5	0.73
KIF2A	3796	O00139	0.82
KIFC3	3801	Q9BVG8	0.82
KIF2C	11004	Q99661	0.82
MAPRE1	22919	Q15691	0.82
WDR62	284403	O43379	0.82
NPHP1	4867	O15259	0.49
ODF2	4957	Q5BJF6	0.49
OFD1	8481	O75665	0.49
CEP135	9662	Q66GS9	0.49
CEP104	9731	O60308	0.49
KIAA0753	9851	Q2KHM9	0.49
CNTRL	11064	Q7Z7A1	0.49
NINL	22981	Q9Y2I6	0.49
MED4	29079	Q9NPJ6	0.49
CENPJ	55835	Q9HC77	0.49
CEP44	80817	Q9C0F1	0.49
CEP89	84902	Q96ST8	0.49
FBF1	85302	Q8TES7	0.49
SCLT1	132320	Q96NL6	0.49
CEP128	145508	Q6ZU80	0.49
CEP120	153241	Q8N960	0.49
SASS6	163786	Q6UVJ0	0.49
SRPK2	6733	P78362	0.52
YWHAG	7532	P61981	0.52
KIF3A	11127	Q9Y496	0.52
IFI16	3428	Q16666	0.63
MYC	4609	P01106	0.63
NTRK1	4914	P04629	0.63
PPP1CA	5499	P62136	0.63
PRKACB	5567	P22694	0.63
VAV2	7410	P52735	0.63
XPO1	7514	O14980	0.63
AURKB	9212	Q96GD4	0.63
CEP57	9702	Q86XR8	0.63
KIAA0101	9768	Q15004	0.63
PAN2	9924	Q504Q3	0.63
TUBGCP3	10426	Q96CW5	0.63
OIP5	11339	O43482	0.63
AGO2	27161	Q9UKV8	0.63
TEKT2	27285	Q9UIF3	0.63
SIRT7	51547	Q9NRC8	0.63
HAUS2	55142	Q9NVX0	0.63
CCAR2	57805	Q8N163	0.63
CCDC68	80323	Q9H2F9	0.63
NDEL1	81565	Q9GZM8	0.63
CCDC8	83987	Q9H0W5	0.63
NEURL4	84461	Q96JN8	0.63
CCDC13	152206	Q8IYE1	0.63
YWHAZ	7534	P63104	0.68
CFTR	1080	P13569	0.72
PCM1	5108	Q15154	0.72
PRKAR2B	5577	P31323	0.72
YWHAB	7529	P31946	0.72
SMC3	9126	Q9UQE7	0.72
FGFR1OP	11116	O95684	0.72
CEP162	22832	Q5TB80	0.72
RPGRIP1L	23322	Q68CZ1	0.72
CEP290	80184	O15078	0.72
TNKS2	80351	Q9H2K2	0.72
LCA5	167691	Q86VQ0	0.72
CSNK1A1	1452	P48729	0.73
HERC2	8924	O95714	0.73
YWHAQ	10971	P27348	0.78
SNAPIN	23557	O95295	0.82
CEP170P1	645455	Q96L14	0.87