Protein Description

Gene Symbol ARHGAP11A
Entrez ID 9824
Uniprot ID Q6P4F7
Description Rho GTPase activating protein 11A
Chromosomal Location chr15: 32,615,144-32,639,949
Ontology GO ID GO Term Definition Evidence

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IEA

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0051056

regulation of small GTPase mediated signal transduction

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0005096

GTPase activator activity

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

TAS

Domain ID Description

IPR000198

Rho GTPase-activating protein domain

IPR008936

Rho GTPase activation protein

No pathways found.

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

C0028754

Obesity

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.49

HIST1H3A

8350

P68431

0.49

SUMO2

6613

P61956

0.63

NXF1

10482

Q9UBU9

0.63

CAPZA2

830

P47755

0.72

DBN1

1627

Q16643

0.72

FLNA

2316

P21333

0.72

MYH9

4627

P35579

0.72

MYO1C

4641

O00159

0.72

PPP1CB

5500

P62140

0.72

IQGAP1

8826

P46940

0.72

SYNPO

11346

Q8N3V7

0.72

ANLN

54443

Q9NQW6

0.72

MYO5C

55930

Q9NQX4

0.72

MYO19

80179

Q96H55

0.72

MYO18A

399687

Q92614

0.72

SFN

2810

P31947

0.76