PCOSBase

Protein Description

Gene Symbol	BCLAF1
Entrez ID	9774
Uniprot ID	Q9NYF8
Description	BCL2-associated transcription factor 1
Chromosomal Location	chr6: 136,256,627-136,289,851

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006351	transcription, DNA-templated	The cellular synthesis of RNA on a template of DNA.	IEA
BP	GO:0006915	apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.	TAS
BP	GO:0043065	positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.	IDA
BP	GO:0043620	regulation of DNA-templated transcription in response to stress	Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).	IMP
BP	GO:0045892	negative regulation of transcription, DNA-templated	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.	IDA\|TAS
BP	GO:2000144	positive regulation of DNA-templated transcription, initiation	Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation.	IMP
BP	GO:2001022	positive regulation of response to DNA damage stimulus	Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.	IMP
BP	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.	IMP
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA
CC	GO:0005730	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IEA
CC	GO:0016607	nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.	IDA
MF	GO:0003677	DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR026668	Bcl-2-associated transcription factor 1
IPR029199	THRAP3/BCLAF1 family

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Pathway ID	Pathway Term	Pathway Source
WP2916	Interactome of polycomb repressive complex 2 (PRC2)	WikiPathways

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UMLS CUI	UMLS Term
C0149925	Small Cell Carcinoma Of Lung

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
liver	hepatocytes
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
17148555	Wood et al.	2007	Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPS9	6203	P46781	0.49
PNN	5411	Q9H307	0.55
LEMD3	23592	Q9Y2U8	0.55
RBMXL1	494115	Q96E39	0.63
PABPN1	8106	Q86U42	0.63
BCL2L1	598	Q07817	0.65
CSNK2A1	1457	P68400	0.70
FMR1	2332	Q06787	0.72
PRMT1	3276	Q99873	0.72
DDX39B	7919	Q13838	0.72
FXR1	8087	P51114	0.72
THOC5	8563	Q13769	0.72
SRSF9	8683	Q13242	0.72
APOBEC3B	9582	Q9UH17	0.72
ZC3H11A	9877	O75152	0.72
ALYREF	10189	Q86V81	0.72
SPEN	23013	Q96T58	0.72
KIAA1429	25962	Q69YN4	0.72
CHTOP	26097	Q9Y3Y2	0.72
PPHLN1	51535	Q8NEY8	0.72
CDK12	51755	Q9NYV4	0.72
THOC2	57187	Q8NI27	0.72
THOC6	79228	Q86W42	0.72
THOC7	80145	Q6I9Y2	0.72
POLDIP3	84271	Q9BY77	0.72
THOC3	84321	Q96J01	0.72
EMD	2010	P50402	0.78
BCL2	596	P10415	0.83
YWHAG	7532	P61981	0.86
THRAP3	9967	Q9Y2W1	0.88
ESR2	2100	Q92731	0.55
PRKCD	5580	Q05655	0.55
GRB2	2885	P62993	0.56
BARD1	580	Q99728	0.63
BMI1	648	P35226	0.63
CDC5L	988	Q99459	0.63
CDK2	1017	P24941	0.63
CHD1	1105	O14646	0.63
CLK1	1195	P49759	0.63
CSNK2A2	1459	P19784	0.63
GRK5	2869	P34947	0.63
MAGOH	4116	P61326	0.63
MCM7	4176	P33993	0.63
MOV10	4343	Q9HCE1	0.63
NEDD8	4738	Q15843	0.63
NTRK1	4914	P04629	0.63
RNF2	6045	Q99496	0.63
SFPQ	6421	P23246	0.63
SUMO3	6612	P55854	0.63
SUMO1	7341	P63165	0.63
VCP	7415	P55072	0.63
XPO1	7514	O14980	0.63
GAN	8139	Q9H2C0	0.63
HIST1H3A	8350	P68431	0.63
CUL3	8452	Q13618	0.63
BAG3	9531	O95817	0.63
SART3	9733	Q15020	0.63
KIAA0101	9768	Q15004	0.63
EIF4A3	9775	P38919	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
SRRM1	10250	Q8IYB3	0.63
NXF1	10482	Q9UBU9	0.63
AHSA1	10598	O95433	0.63
RNPS1	10921	Q15287	0.63
SPIN1	10927	Q9Y657	0.63
ZBTB1	22890	Q9Y2K1	0.63
PAXIP1	22976	Q6ZW49	0.63
OBSL1	23363	O75147	0.63
TARDBP	23435	Q13148	0.63
SUZ12	23512	Q15022	0.63
MED4	29079	Q9NPJ6	0.63
ASB3	51130	Q9Y575	0.63
LUZP4	51213	Q9P127	0.63
LUC7L2	51631	Q9Y383	0.63
LUC7L	55692	Q9NQ29	0.63
CAND1	55832	Q86VP6	0.63
PRMT8	56341	Q9NR22	0.63
SMURF1	57154	Q9HCE7	0.63
MTA3	57504	Q9BTC8	0.63
UNK	85451	Q9C0B0	0.63
ALKBH3	221120	Q96Q83	0.63
ASB18	401036	Q6ZVZ8	0.63
CASP10	843	Q92851	0.68
PIN1	5300	Q13526	0.68
ARRB1	408	P49407	0.72
ARRB2	409	P32121	0.72
CLK2	1196	P49760	0.72
CLK3	1198	P49761	0.72
PDGFRB	5159	P09619	0.72
SRPK1	6732	Q96SB4	0.72
THOC1	9984	Q96FV9	0.72
CBX8	57332	Q9HC52	0.72
MYH7B	57644	A7E2Y1	0.72
HDAC11	79885	Q96DB2	0.72
CDKN2AIPNL	91368	Q96HQ2	0.72
EGFR	1956	P00533	0.73
SUMO2	6613	P61956	0.74
ESR1	2099	P03372	0.77
SRPK2	6733	P78362	0.83
SNW1	22938	Q13573	0.84
SNIP1	79753	Q8TAD8	0.88