| Gene Symbol | HS2ST1 |
| Entrez ID | 9653 |
| Uniprot ID | Q7LGA3 |
| Description | heparan sulfate 2-O-sulfotransferase 1 |
| Chromosomal Location | chr1: 86,914,648-87,109,998 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006024 |
glycosaminoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. |
TAS |
|
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0004394 |
heparan sulfate 2-O-sulfotransferase activity |
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR005331 |
Sulfotransferase |
|
IPR007734 |
Heparan sulphate 2-O-sulfotransferase |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00534 |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
KEGG |
|
WP702 |
Metapathway biotransformation |
WikiPathways |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
lymphoid tissue |
|
caudate |
neuronal cells |
|
cerebellum |
Purkinje cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
lymph node |
germinal center cells |
|
pancreas |
exocrine glandular cells |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
testis |
Leydig cells |
|
tonsil |
germinal center cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
23824412 |
Piltonen et al. |
2013 |
Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ATP12A |
479 |
P54707 |
0.63 |
|
HLA-A |
3105 |
P30443 |
0.63 |
|
CKAP4 |
10970 |
Q07065 |
0.63 |
|
DYM |
54808 |
Q7RTS9 |
0.63 |
|
TBC1D23 |
55773 |
Q9NUY8 |
0.63 |
|
DIAPH3 |
81624 |
Q9NSV4 |
0.63 |
|
PIGU |
128869 |
Q9H490 |
0.63 |
|
NMNAT3 |
349565 |
Q96T66 |
0.63 |
|
P2RX4 |
5025 |
Q99571 |
0.63 |
|
PEX19 |
5824 |
P40855 |
0.63 |
|
TGOLN2 |
10618 |
O43493 |
0.63 |
|
TSPAN17 |
26262 |
Q96FV3 |
0.63 |
|
CHRNA9 |
55584 |
Q9UGM1 |
0.63 |