| Gene Symbol | HS2ST1 |
| Entrez ID | 9653 |
| Uniprot ID | Q7LGA3 |
| Description | heparan sulfate 2-O-sulfotransferase 1 |
| Chromosomal Location | chr1: 86,914,648-87,109,998 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006024 | glycosaminoglycan biosynthetic process |
The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. | TAS |
CC | GO:0000139 | Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. | TAS |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
MF | GO:0004394 | heparan sulfate 2-O-sulfotransferase activity |
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. | TAS |
| Domain ID | Description |
|---|---|
IPR005331 | Sulfotransferase |
IPR007734 | Heparan sulphate 2-O-sulfotransferase |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | KEGG |
WP702 | Metapathway biotransformation | WikiPathways |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | lymphoid tissue |
caudate | neuronal cells |
cerebellum | Purkinje cells |
duodenum | glandular cells |
endometrium | glandular cells |
epididymis | glandular cells |
fallopian tube | glandular cells |
hippocampus | neuronal cells |
kidney | cells in tubules |
lymph node | germinal center cells |
pancreas | exocrine glandular cells |
small intestine | glandular cells |
spleen | cells in red pulp |
testis | Leydig cells |
tonsil | germinal center cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
23824412 | Piltonen et al. | 2013 | Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
ATP12A | 479 | P54707 | 0.63 |
HLA-A | 3105 | P30443 | 0.63 |
CKAP4 | 10970 | Q07065 | 0.63 |
DYM | 54808 | Q7RTS9 | 0.63 |
TBC1D23 | 55773 | Q9NUY8 | 0.63 |
DIAPH3 | 81624 | Q9NSV4 | 0.63 |
PIGU | 128869 | Q9H490 | 0.63 |
NMNAT3 | 349565 | Q96T66 | 0.63 |
P2RX4 | 5025 | Q99571 | 0.63 |
PEX19 | 5824 | P40855 | 0.63 |
TGOLN2 | 10618 | O43493 | 0.63 |
TSPAN17 | 26262 | Q96FV3 | 0.63 |
CHRNA9 | 55584 | Q9UGM1 | 0.63 |