| Gene Symbol | ISG15 |
| Entrez ID | 9636 |
| Uniprot ID | P05161 |
| Description | ISG15 ubiquitin-like modifier |
| Chromosomal Location | chr1: 1,001,138-1,014,541 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0019941 |
modification-dependent protein catabolic process |
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. |
IEA |
|
BP |
GO:0019985 |
translesion synthesis |
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. |
TAS |
|
BP |
GO:0031397 |
negative regulation of protein ubiquitination |
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. |
IDA |
|
BP |
GO:0032020 |
ISG15-protein conjugation |
The covalent addition to a protein of ISG15, a ubiquitin-like protein. |
IDA|IMP |
|
BP |
GO:0032480 |
negative regulation of type I interferon production |
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
TAS |
|
BP |
GO:0032649 |
regulation of interferon-gamma production |
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
IMP |
|
BP |
GO:0034340 |
response to type I interferon |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
IDA |
|
BP |
GO:0042742 |
defense response to bacterium |
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
IMP |
|
BP |
GO:0045071 |
negative regulation of viral genome replication |
Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication. |
IMP |
|
BP |
GO:0045648 |
positive regulation of erythrocyte differentiation |
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. |
IEA |
|
BP |
GO:0051607 |
defense response to virus |
Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
IMP |
|
BP |
GO:0060337 |
type I interferon signaling pathway |
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
TAS |
|
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0031386 |
protein tag |
Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000626 |
Ubiquitin domain |
|
IPR019956 |
Ubiquitin |
|
IPR029071 |
Ubiquitin-related domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04622 |
RIG-I-like receptor signaling pathway |
KEGG |
|
WP619 |
Type II interferon signaling (IFNG) |
WikiPathways |
|
WP3865 |
RIG-I-like Receptor Signaling |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0021400 |
Influenza |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
keratinocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
18765015 |
Qiao et al. |
2008 |
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
UGP2 |
7360 |
Q16851 |
0.49 |
|
ZNF318 |
24149 |
Q5VUA4 |
0.49 |
|
AARS |
16 |
P49588 |
0.63 |
|
ACTA1 |
58 |
P68133 |
0.63 |
|
ACTB |
60 |
P60709 |
0.63 |
|
ACTN4 |
81 |
O43707 |
0.63 |
|
ACTN1 |
87 |
P12814 |
0.63 |
|
ALDOA |
226 |
P04075 |
0.63 |
|
ANXA3 |
306 |
P12429 |
0.63 |
|
ANXA5 |
308 |
P08758 |
0.63 |
|
ATIC |
471 |
P31939 |
0.63 |
|
ATP5A1 |
498 |
P25705 |
0.63 |
|
ATP5B |
506 |
P06576 |
0.63 |
|
CALD1 |
800 |
Q05682 |
0.63 |
|
CHD1 |
1105 |
O14646 |
0.63 |
|
CLIC1 |
1192 |
O00299 |
0.63 |
|
CLK1 |
1195 |
P49759 |
0.63 |
|
CLTC |
1213 |
Q00610 |
0.63 |
|
CSNK2A1 |
1457 |
P68400 |
0.63 |
|
DDB2 |
1643 |
Q92466 |
0.63 |
|
DYRK1A |
1859 |
Q13627 |
0.63 |
|
EEF1A1 |
1915 |
P68104 |
0.63 |
|
EEF1A2 |
1917 |
Q05639 |
0.63 |
|
EEF1G |
1937 |
P26641 |
0.63 |
|
EIF4G1 |
1981 |
Q04637 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
EPRS |
2058 |
P07814 |
0.63 |
|
ERCC2 |
2068 |
P18074 |
0.63 |
|
FASN |
2194 |
P49327 |
0.63 |
|
FLNA |
2316 |
P21333 |
0.63 |
|
FUT4 |
2526 |
P22083 |
0.63 |
|
XRCC6 |
2547 |
P12956 |
0.63 |
|
GAPDH |
2597 |
P04406 |
0.63 |
|
GBP1 |
2633 |
P32455 |
0.63 |
|
GDI2 |
2665 |
P50395 |
0.63 |
|
SFN |
2810 |
P31947 |
0.63 |
|
GSR |
2936 |
P00390 |
0.63 |
|
GSTP1 |
2950 |
P09211 |
0.63 |
|
HNRNPA2B1 |
3181 |
P22626 |
0.63 |
|
HNRNPK |
3190 |
P61978 |
0.63 |
|
HNRNPL |
3191 |
P14866 |
0.63 |
|
HNRNPU |
3192 |
Q00839 |
0.63 |
|
HSPA1A |
3303 |
P0DMV8 |
0.63 |
|
HSPA1B |
3304 |
P0DMV9 |
0.63 |
|
HSPA4 |
3308 |
P34932 |
0.63 |
|
HSPB1 |
3315 |
P04792 |
0.63 |
|
HSPD1 |
3329 |
P10809 |
0.63 |
|
DNAJB1 |
3337 |
P25685 |
0.63 |
|
IFIT2 |
3433 |
P09913 |
0.63 |
|
IFIT1 |
3434 |
P09914 |
0.63 |
|
IFIT3 |
3437 |
O14879 |
0.63 |
|
IRF3 |
3661 |
Q14653 |
0.63 |
|
LMNA |
4000 |
P02545 |
0.63 |
|
SMAD4 |
4089 |
Q13485 |
0.63 |
|
MAP4 |
4134 |
P27816 |
0.63 |
|
MDH1 |
4190 |
P40925 |
0.63 |
|
MSN |
4478 |
P26038 |
0.63 |
|
MX1 |
4599 |
P20591 |
0.63 |
|
MYH9 |
4627 |
P35579 |
0.63 |
|
NACA |
4666 |
Q13765 |
0.63 |
|
NFIX |
4784 |
Q14938 |
0.63 |
|
OGDH |
4967 |
Q02218 |
0.63 |
|
PAFAH1B1 |
5048 |
P43034 |
0.63 |
|
PFN1 |
5216 |
P07737 |
0.63 |
|
PGD |
5226 |
P52209 |
0.63 |
|
PGK1 |
5230 |
P00558 |
0.63 |
|
SERPINB5 |
5268 |
P36952 |
0.63 |
|
PLEC |
5339 |
Q15149 |
0.63 |
|
PLOD1 |
5351 |
Q02809 |
0.63 |
|
PLS1 |
5357 |
Q14651 |
0.63 |
|
PLS3 |
5358 |
P13797 |
0.63 |
|
PPP1R10 |
5514 |
Q96QC0 |
0.63 |
|
EIF2AK2 |
5610 |
P19525 |
0.63 |
|
LGMN |
5641 |
Q99538 |
0.63 |
|
PSMA7 |
5688 |
O14818 |
0.63 |
|
PTBP1 |
5725 |
P26599 |
0.63 |
|
RAN |
5901 |
P62826 |
0.63 |
|
RBBP4 |
5928 |
Q09028 |
0.63 |
|
RGS3 |
5998 |
P49796 |
0.63 |
|
RPL24 |
6152 |
P83731 |
0.63 |
|
RPL27A |
6157 |
P46776 |
0.63 |
|
RPS27A |
6233 |
P62979 |
0.63 |
|
ATXN2 |
6311 |
Q99700 |
0.63 |
|
TAF2 |
6873 |
Q6P1X5 |
0.63 |
|
TAGLN |
6876 |
Q01995 |
0.63 |
|
TKT |
7086 |
P29401 |
0.63 |
|
TOP2A |
7153 |
P11388 |
0.63 |
|
CCT3 |
7203 |
P49368 |
0.63 |
|
TXNRD1 |
7296 |
Q16881 |
0.63 |
|
EZR |
7430 |
P15311 |
0.63 |
|
VIM |
7431 |
P08670 |
0.63 |
|
WARS |
7453 |
P23381 |
0.63 |
|
XRCC5 |
7520 |
P13010 |
0.63 |
|
AAAS |
8086 |
Q9NRG9 |
0.63 |
|
SF3A2 |
8175 |
Q15428 |
0.63 |
|
CBX4 |
8535 |
O00257 |
0.63 |
|
IQGAP1 |
8826 |
P46940 |
0.63 |
|
FUBP3 |
8939 |
Q96I24 |
0.63 |
|
PLOD3 |
8985 |
O60568 |
0.63 |
|
AIFM1 |
9131 |
O95831 |
0.63 |
|
UBE2L6 |
9246 |
O14933 |
0.63 |
|
PRDX6 |
9588 |
P30041 |
0.63 |
|
UBAP2L |
9898 |
Q14157 |
0.63 |
|
WDR1 |
9948 |
O75083 |
0.63 |
|
ACOT8 |
10005 |
O14734 |
0.63 |
|
ABCF2 |
10061 |
Q9UG63 |
0.63 |
|
G3BP1 |
10146 |
Q13283 |
0.63 |
|
SF3B4 |
10262 |
Q15427 |
0.63 |
|
RACK1 |
10399 |
P63244 |
0.63 |
|
DDX17 |
10521 |
Q92841 |
0.63 |
|
CCT4 |
10575 |
P50991 |
0.63 |
|
CCT2 |
10576 |
P78371 |
0.63 |
|
FARS2 |
10667 |
O95363 |
0.63 |
|
LMAN2 |
10960 |
Q12907 |
0.63 |
|
DSTN |
11034 |
P60981 |
0.63 |
|
DNAJB4 |
11080 |
Q9UDY4 |
0.63 |
|
ATXN2L |
11273 |
Q8WWM7 |
0.63 |
|
DDX42 |
11325 |
Q86XP3 |
0.63 |
|
STK38 |
11329 |
Q15208 |
0.63 |
|
SNRNP200 |
23020 |
O75643 |
0.63 |
|
PALLD |
23022 |
Q8WX93 |
0.63 |
|
GANAB |
23193 |
Q14697 |
0.63 |
|
ZNF281 |
23528 |
Q9Y2X9 |
0.63 |
|
IFIT5 |
24138 |
Q13325 |
0.63 |
|
SIN3A |
25942 |
Q96ST3 |
0.63 |
|
SERBP1 |
26135 |
Q8NC51 |
0.63 |
|
PHGDH |
26227 |
O43175 |
0.63 |
|
MYOF |
26509 |
Q9NZM1 |
0.63 |
|
TMOD3 |
29766 |
Q9NYL9 |
0.63 |
|
SENP1 |
29843 |
Q9P0U3 |
0.63 |
|
RBM15B |
29890 |
Q8NDT2 |
0.63 |
|
LAP3 |
51056 |
P28838 |
0.63 |
|
RDH11 |
51109 |
Q8TC12 |
0.63 |
|
FAM120C |
54954 |
Q9NX05 |
0.63 |
|
WDR33 |
55339 |
Q9C0J8 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
ZC3H15 |
55854 |
Q8WU90 |
0.63 |
|
MEPCE |
56257 |
Q7L2J0 |
0.63 |
|
ZC3HAV1 |
56829 |
Q7Z2W4 |
0.63 |
|
CCNL1 |
57018 |
Q9UK58 |
0.63 |
|
AHNAK |
79026 |
Q09666 |
0.63 |
|
QTRTD1 |
79691 |
Q9H974 |
0.63 |
|
EPPK1 |
83481 |
P58107 |
0.63 |
|
ARID5B |
84159 |
Q14865 |
0.63 |
|
PYM1 |
84305 |
Q9BRP8 |
0.63 |
|
UTP4 |
84916 |
Q969X6 |
0.63 |
|
HELZ2 |
85441 |
Q9BYK8 |
0.63 |
|
DEPDC7 |
91614 |
Q96QD5 |
0.63 |
|
YTHDC1 |
91746 |
Q96MU7 |
0.63 |
|
YTHDF3 |
253943 |
Q7Z739 |
0.63 |
|
NUP43 |
348995 |
Q8NFH3 |
0.63 |
|
ACLY |
47 |
P53396 |
0.73 |
|
ANXA2 |
302 |
P07355 |
0.73 |
|
CFL1 |
1072 |
P23528 |
0.73 |
|
EEF2 |
1938 |
P13639 |
0.73 |
|
GPI |
2821 |
P06744 |
0.73 |
|
HSP90AA1 |
3320 |
P07900 |
0.73 |
|
HSP90AB1 |
3326 |
P08238 |
0.73 |
|
LDHA |
3939 |
P00338 |
0.73 |
|
PRDX1 |
5052 |
Q06830 |
0.73 |
|
PKM |
5315 |
P14618 |
0.73 |
|
STAT1 |
6772 |
P42224 |
0.73 |
|
TARS |
6897 |
P26639 |
0.73 |
|
VCP |
7415 |
P55072 |
0.73 |
|
TRIM25 |
7706 |
Q14258 |
0.73 |
|
ENO1 |
2023 |
P06733 |
0.74 |
|
HSPA8 |
3312 |
P11142 |
0.74 |
|
UBE2N |
7334 |
P61088 |
0.74 |
|
HERC5 |
51191 |
Q9UII4 |
0.74 |
|
USP18 |
11274 |
Q9UMW8 |
0.83 |
|
PPM1B |
5495 |
O75688 |
0.86 |
|
USP21 |
27005 |
Q9UK80 |
0.52 |
|
CTNNB1 |
1499 |
P35222 |
0.63 |
|
IFNA2 |
3440 |
P01563 |
0.63 |
|
IFNA5 |
3442 |
P01569 |
0.63 |
|
IFNA8 |
3445 |
P32881 |
0.63 |
|
IFNA14 |
3448 |
P01570 |
0.63 |
|
NEDD4 |
4734 |
P46934 |
0.63 |
|
SEPT2 |
4735 |
Q15019 |
0.63 |
|
NFKB1 |
4790 |
P19838 |
0.63 |
|
PCNA |
5111 |
P12004 |
0.63 |
|
UBE2D3 |
7323 |
P61077 |
0.63 |
|
UBE2E1 |
7324 |
P51965 |
0.63 |
|
BAG3 |
9531 |
O95817 |
0.63 |
|
SQSTM1 |
8878 |
Q13501 |
0.68 |
|
HDAC6 |
10013 |
Q9UBN7 |
0.68 |
|
ELF3 |
1999 |
P78545 |
0.72 |
|
DDX58 |
23586 |
O95786 |
0.73 |
|
CHMP5 |
51510 |
Q9NZZ3 |
0.73 |
|
UBA1 |
7317 |
P22314 |
0.78 |
|
UBE2E2 |
7325 |
Q96LR5 |
0.78 |
|
UBA7 |
7318 |
P41226 |
0.85 |
|
FLNB |
2317 |
O75369 |
0.87 |