Protein Description

Gene Symbol GUCA1C
Entrez ID 9626
Uniprot ID O95843
Description guanylate cyclase activator 1C
Chromosomal Location chr3: 108,907,792-108,953,895
Ontology GO ID GO Term Definition Evidence

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007601

visual perception

The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

IEA

BP

GO:0022400

regulation of rhodopsin mediated signaling pathway

Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.

TAS

BP

GO:0031284

positive regulation of guanylate cyclase activity

Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.

IEA

CC

GO:0097381

photoreceptor disc membrane

Ovally-shaped membranous stack located inside the photoreceptor outer segment, and containing densely packed molecules of the photoreceptor protein rhodopsin that traverse the lipid bilayer. Disc membranes are apparently derived from the plasma membrane in the region of the cilium that connects the photoreceptor outer segment to the inner segment.

TAS

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0008048

calcium sensitive guanylate cyclase activator activity

Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.

IEA

Domain ID Description

IPR002048

EF-hand domain

IPR011992

EF-hand domain pair

IPR018247

EF-Hand 1, calcium-binding site

IPR032992

Guanylyl cyclase-activating protein 3

Pathway ID Pathway Term Pathway Source

hsa04744

Phototransduction

KEGG

No diseases found.

No tissues found.

No databases found.

Pubmed ID Author Year Title

15598877

Wood et al.

2005

Valproate-induced alterations in human theca cell gene expression: clues to the association between valproate use and metabolic side effects

No partners found.