Protein Description

Gene Symbol POLR1C
Entrez ID 9533
Uniprot ID O15160
Description polymerase (RNA) I polypeptide C
Chromosomal Location chr6: 43,509,702-43,529,585
Ontology GO ID GO Term Definition Evidence

BP

GO:0006360

transcription from RNA polymerase I promoter

The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.

TAS

BP

GO:0006361

transcription initiation from RNA polymerase I promoter

Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.

TAS

BP

GO:0006362

transcription elongation from RNA polymerase I promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.

TAS

BP

GO:0006363

termination of RNA polymerase I transcription

The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.

TAS

BP

GO:0006383

transcription from RNA polymerase III promoter

The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.

IEA

BP

GO:0032481

positive regulation of type I interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

TAS

BP

GO:0045815

positive regulation of gene expression, epigenetic

Any epigenetic process that activates or increases the rate of gene expression.

TAS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005666

DNA-directed RNA polymerase III complex

RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

IDA

CC

GO:0005736

DNA-directed RNA polymerase I complex

RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0001054

RNA polymerase I activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

IBA

MF

GO:0001056

RNA polymerase III activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

IBA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0003899

DNA-directed RNA polymerase activity

Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0046983

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

IEA

Domain ID Description

IPR001514

DNA-directed RNA polymerase, 30-40kDa subunit, conserved site

IPR009025

DNA-directed RNA polymerase, RBP11-like dimerisation domain

IPR011262

DNA-directed RNA polymerase, insert domain

IPR011263

DNA-directed RNA polymerase, RpoA/D/Rpb3-type

IPR033901

DNA-directed RNA polymerases I and III subunit AC40

Pathway ID Pathway Term Pathway Source

hsa00230

Purine metabolism

KEGG

hsa00240

Pyrimidine metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa03020

RNA polymerase

KEGG

hsa04623

Cytosolic DNA-sensing pathway

KEGG

hsa05169

Epstein-Barr virus infection

KEGG

h_arfPathway

Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

BioCarta

UMLS CUI UMLS Term

C0242387

Mandibulofacial Dysostosis

No tissues found.

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

RUVBL1

8607

Q9Y265

0.49

ABCF2

10061

Q9UG63

0.49

POLR3G

10622

O15318

0.49

GTPBP4

23560

Q9BZE4

0.49

DCAF13

25879

Q9NV06

0.49

DDX47

51202

Q9H0S4

0.49

GAR1

54433

Q9NY12

0.49

WDR36

134430

Q8NI36

0.49

NOP9

161424

Q86U38

0.49

TWISTNB

221830

Q3B726

0.49

NMD3

51068

Q96D46

0.56

POLR2L

5441

P62875

0.58

POLR3F

10621

Q9H1D9

0.58

POLR3C

10623

Q9BUI4

0.59

TSR1

55720

Q2NL82

0.59

MYO5B

4645

Q9ULV0

0.63

NMT1

4836

P30419

0.63

VIM

7431

P08670

0.63

CORO1A

11151

P31146

0.63

IKZF3

22806

Q9UKT9

0.63

MBIP

51562

Q9NS73

0.63

FAM208B

54906

Q5VWN6

0.63

PPP2R3C

55012

Q969Q6

0.63

CORO1B

57175

Q9BR76

0.63

BIRC7

79444

Q96CA5

0.63

CCDC33

80125

Q8N5R6

0.63

TSC22D4

81628

Q9Y3Q8

0.63

ATRIP

84126

Q8WXE1

0.63

LZTS2

84445

Q9BRK4

0.63

RIMBP3

85376

Q9UFD9

0.63

SAXO1

158297

Q8IYX7

0.63

KCTD1

284252

Q719H9

0.63

CCDC36

339834

Q8IYA8

0.63

MYD88

4615

Q99836

0.65

POLR3A

11128

O14802

0.65

CRCP

27297

O75575

0.65

POLR3B

55703

Q9NW08

0.65

POLR3H

171568

Q9Y535

0.68

POLR2J

5439

P52435

0.73

WRN

7486

Q14191

0.73

BYSL

705

Q13895

0.49

C1QBP

708

Q07021

0.49

CFL1

1072

P23528

0.49

CIRBP

1153

Q14011

0.49

CTPS1

1503

P17812

0.49

DKC1

1736

O60832

0.49

EIF4B

1975

P23588

0.49

NCL

4691

P19338

0.49

POLR2C

5432

P19387

0.49

PSMB7

5695

Q99436

0.49

SMARCA2

6595

P51531

0.49

SSB

6741

P05455

0.49

TP53BP1

7158

Q12888

0.49

SMARCA5

8467

O60264

0.49

DDX18

8886

Q9NVP1

0.49

PUM3

9933

Q15397

0.49

HYOU1

10525

Q9Y4L1

0.49

EBNA1BP2

10969

Q99848

0.49

NSUN5

55695

Q96P11

0.49

BCCIP

56647

Q9P287

0.49

DDX24

57062

Q9GZR7

0.49

POLR2K

5440

P53803

0.56

EIF3I

8668

Q13347

0.56

RPL13A

23521

P40429

0.56

POLR3K

51728

Q9Y2Y1

0.56

DHX37

57647

Q8IY37

0.59

CDC5L

988

Q99459

0.63

CLU

1191

P10909

0.63

DDX1

1653

Q92499

0.63

JUN

3725

P05412

0.63

KRT19

3880

P08727

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

TRIM27

5987

P14373

0.63

SUMO2

6613

P61956

0.63

TCF4

6925

P15884

0.63

CUL3

8452

Q13618

0.63

CIAO1

9391

O76071

0.63

TRIOBP

11078

Q9H2D6

0.63

SNW1

22938

Q13573

0.63

CNOT1

23019

A5YKK6

0.63

PHLDA3

23612

Q9Y5J5

0.63

AGO1

26523

Q9UL18

0.63

GPN3

51184

Q9UHW5

0.63

RTCB

51493

Q9Y3I0

0.63

GSTK1

373156

Q9Y2Q3

0.63

SMN1; SMN2

6606

Q16637

0.63

CD3EAP

10849

O15446

0.65

POLR1B

84172

Q9H9Y6

0.65

POLR2E

5434

P19388

0.68

POLR2H

5437

P52434

0.68

ARRB1

408

P49407

0.72

ARRB2

409

P32121

0.72

FN1

2335

P02751

0.72

PMS1

5378

P54277

0.72

POLR3E

55718

Q9NVU0

0.72

NFKBIB

4793

Q15653

0.73

TNFAIP1

7126

Q13829

0.73

NME1

4830

P15531

0.74

USP11

8237

P51784

0.76

TAF1D

79101

Q9H5J8

0.76

WDR20

91833

Q8TBZ3

0.76

POLR3D

661

P05423

0.83

POLR1D

51082

Q9Y2S0

0.84

POLR2F

5435

P61218

0.91

POLR1A

25885

O95602

0.91

POLR1E

64425

Q9GZS1

0.96