Gene Symbol | POLR1C |
Entrez ID | 9533 |
Uniprot ID | O15160 |
Description | polymerase (RNA) I polypeptide C |
Chromosomal Location | chr6: 43,509,702-43,529,585 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006360 |
transcription from RNA polymerase I promoter |
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. |
TAS |
BP |
GO:0006361 |
transcription initiation from RNA polymerase I promoter |
Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. |
TAS |
BP |
GO:0006362 |
transcription elongation from RNA polymerase I promoter |
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. |
TAS |
BP |
GO:0006363 |
termination of RNA polymerase I transcription |
The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit. |
TAS |
BP |
GO:0006383 |
transcription from RNA polymerase III promoter |
The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. |
IEA |
BP |
GO:0032481 |
positive regulation of type I interferon production |
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
TAS |
BP |
GO:0045815 |
positive regulation of gene expression, epigenetic |
Any epigenetic process that activates or increases the rate of gene expression. |
TAS |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005666 |
DNA-directed RNA polymerase III complex |
RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. |
IDA |
CC |
GO:0005736 |
DNA-directed RNA polymerase I complex |
RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0001054 |
RNA polymerase I activity |
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
IBA |
MF |
GO:0001056 |
RNA polymerase III activity |
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
IBA |
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
IEA |
MF |
GO:0003899 |
DNA-directed RNA polymerase activity |
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0046983 |
protein dimerization activity |
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. |
IEA |
Domain ID | Description |
---|---|
IPR001514 |
DNA-directed RNA polymerase, 30-40kDa subunit, conserved site |
IPR009025 |
DNA-directed RNA polymerase, RBP11-like dimerisation domain |
IPR011262 |
DNA-directed RNA polymerase, insert domain |
IPR011263 |
DNA-directed RNA polymerase, RpoA/D/Rpb3-type |
IPR033901 |
DNA-directed RNA polymerases I and III subunit AC40 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00230 |
Purine metabolism |
KEGG |
hsa00240 |
Pyrimidine metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa03020 |
RNA polymerase |
KEGG |
hsa04623 |
Cytosolic DNA-sensing pathway |
KEGG |
hsa05169 |
Epstein-Barr virus infection |
KEGG |
h_arfPathway |
Tumor Suppressor Arf Inhibits Ribosomal Biogenesis |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0242387 |
Mandibulofacial Dysostosis |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
RUVBL1 |
8607 |
Q9Y265 |
0.49 |
ABCF2 |
10061 |
Q9UG63 |
0.49 |
POLR3G |
10622 |
O15318 |
0.49 |
GTPBP4 |
23560 |
Q9BZE4 |
0.49 |
DCAF13 |
25879 |
Q9NV06 |
0.49 |
DDX47 |
51202 |
Q9H0S4 |
0.49 |
GAR1 |
54433 |
Q9NY12 |
0.49 |
WDR36 |
134430 |
Q8NI36 |
0.49 |
NOP9 |
161424 |
Q86U38 |
0.49 |
TWISTNB |
221830 |
Q3B726 |
0.49 |
NMD3 |
51068 |
Q96D46 |
0.56 |
POLR2L |
5441 |
P62875 |
0.58 |
POLR3F |
10621 |
Q9H1D9 |
0.58 |
POLR3C |
10623 |
Q9BUI4 |
0.59 |
TSR1 |
55720 |
Q2NL82 |
0.59 |
MYO5B |
4645 |
Q9ULV0 |
0.63 |
NMT1 |
4836 |
P30419 |
0.63 |
VIM |
7431 |
P08670 |
0.63 |
CORO1A |
11151 |
P31146 |
0.63 |
IKZF3 |
22806 |
Q9UKT9 |
0.63 |
MBIP |
51562 |
Q9NS73 |
0.63 |
FAM208B |
54906 |
Q5VWN6 |
0.63 |
PPP2R3C |
55012 |
Q969Q6 |
0.63 |
CORO1B |
57175 |
Q9BR76 |
0.63 |
BIRC7 |
79444 |
Q96CA5 |
0.63 |
CCDC33 |
80125 |
Q8N5R6 |
0.63 |
TSC22D4 |
81628 |
Q9Y3Q8 |
0.63 |
ATRIP |
84126 |
Q8WXE1 |
0.63 |
LZTS2 |
84445 |
Q9BRK4 |
0.63 |
RIMBP3 |
85376 |
Q9UFD9 |
0.63 |
SAXO1 |
158297 |
Q8IYX7 |
0.63 |
KCTD1 |
284252 |
Q719H9 |
0.63 |
CCDC36 |
339834 |
Q8IYA8 |
0.63 |
MYD88 |
4615 |
Q99836 |
0.65 |
POLR3A |
11128 |
O14802 |
0.65 |
CRCP |
27297 |
O75575 |
0.65 |
POLR3B |
55703 |
Q9NW08 |
0.65 |
POLR3H |
171568 |
Q9Y535 |
0.68 |
POLR2J |
5439 |
P52435 |
0.73 |
WRN |
7486 |
Q14191 |
0.73 |
BYSL |
705 |
Q13895 |
0.49 |
C1QBP |
708 |
Q07021 |
0.49 |
CFL1 |
1072 |
P23528 |
0.49 |
CIRBP |
1153 |
Q14011 |
0.49 |
CTPS1 |
1503 |
P17812 |
0.49 |
DKC1 |
1736 |
O60832 |
0.49 |
EIF4B |
1975 |
P23588 |
0.49 |
NCL |
4691 |
P19338 |
0.49 |
POLR2C |
5432 |
P19387 |
0.49 |
PSMB7 |
5695 |
Q99436 |
0.49 |
SMARCA2 |
6595 |
P51531 |
0.49 |
SSB |
6741 |
P05455 |
0.49 |
TP53BP1 |
7158 |
Q12888 |
0.49 |
SMARCA5 |
8467 |
O60264 |
0.49 |
DDX18 |
8886 |
Q9NVP1 |
0.49 |
PUM3 |
9933 |
Q15397 |
0.49 |
HYOU1 |
10525 |
Q9Y4L1 |
0.49 |
EBNA1BP2 |
10969 |
Q99848 |
0.49 |
NSUN5 |
55695 |
Q96P11 |
0.49 |
BCCIP |
56647 |
Q9P287 |
0.49 |
DDX24 |
57062 |
Q9GZR7 |
0.49 |
POLR2K |
5440 |
P53803 |
0.56 |
EIF3I |
8668 |
Q13347 |
0.56 |
RPL13A |
23521 |
P40429 |
0.56 |
POLR3K |
51728 |
Q9Y2Y1 |
0.56 |
DHX37 |
57647 |
Q8IY37 |
0.59 |
CDC5L |
988 |
Q99459 |
0.63 |
CLU |
1191 |
P10909 |
0.63 |
DDX1 |
1653 |
Q92499 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
KRT19 |
3880 |
P08727 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
TRIM27 |
5987 |
P14373 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
TCF4 |
6925 |
P15884 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
CIAO1 |
9391 |
O76071 |
0.63 |
TRIOBP |
11078 |
Q9H2D6 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
CNOT1 |
23019 |
A5YKK6 |
0.63 |
PHLDA3 |
23612 |
Q9Y5J5 |
0.63 |
AGO1 |
26523 |
Q9UL18 |
0.63 |
GPN3 |
51184 |
Q9UHW5 |
0.63 |
RTCB |
51493 |
Q9Y3I0 |
0.63 |
GSTK1 |
373156 |
Q9Y2Q3 |
0.63 |
SMN1; SMN2 |
6606 |
Q16637 |
0.63 |
CD3EAP |
10849 |
O15446 |
0.65 |
POLR1B |
84172 |
Q9H9Y6 |
0.65 |
POLR2E |
5434 |
P19388 |
0.68 |
POLR2H |
5437 |
P52434 |
0.68 |
ARRB1 |
408 |
P49407 |
0.72 |
ARRB2 |
409 |
P32121 |
0.72 |
FN1 |
2335 |
P02751 |
0.72 |
PMS1 |
5378 |
P54277 |
0.72 |
POLR3E |
55718 |
Q9NVU0 |
0.72 |
NFKBIB |
4793 |
Q15653 |
0.73 |
TNFAIP1 |
7126 |
Q13829 |
0.73 |
NME1 |
4830 |
P15531 |
0.74 |
USP11 |
8237 |
P51784 |
0.76 |
TAF1D |
79101 |
Q9H5J8 |
0.76 |
WDR20 |
91833 |
Q8TBZ3 |
0.76 |
POLR3D |
661 |
P05423 |
0.83 |
POLR1D |
51082 |
Q9Y2S0 |
0.84 |
POLR2F |
5435 |
P61218 |
0.91 |
POLR1A |
25885 |
O95602 |
0.91 |
POLR1E |
64425 |
Q9GZS1 |
0.96 |