Gene Symbol | CCND2 |
Entrez ID | 894 |
Uniprot ID | P30279 |
Description | cyclin D2 |
Chromosomal Location | chr12: 4,273,772-4,305,350 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001934 |
positive regulation of protein phosphorylation |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
IDA |
BP |
GO:0007049 |
cell cycle |
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
IEA |
BP |
GO:0008284 |
positive regulation of cell proliferation |
Any process that activates or increases the rate or extent of cell proliferation. |
IMP |
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IMP |
BP |
GO:0045737 |
positive regulation of cyclin-dependent protein serine/threonine kinase activity |
Any process that activates or increases the frequency, rate or extent of CDK activity. |
IDA |
BP |
GO:0051301 |
cell division |
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
IEA |
BP |
GO:1900087 |
positive regulation of G1/S transition of mitotic cell cycle |
Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle. |
IMP |
CC |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. |
IDA |
CC |
GO:0000785 |
chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA |
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019901 |
protein kinase binding |
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
IPI |
Domain ID | Description |
---|---|
IPR004367 |
Cyclin, C-terminal domain |
IPR006671 |
Cyclin, N-terminal |
IPR013763 |
Cyclin-like |
IPR015451 |
Cyclin D |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04068 |
FoxO signaling pathway |
KEGG |
hsa04110 |
Cell cycle |
KEGG |
hsa04115 |
p53 signaling pathway |
KEGG |
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
hsa04310 |
Wnt signaling pathway |
KEGG |
hsa04340 |
Hedgehog signaling pathway |
KEGG |
hsa04390 |
Hippo signaling pathway |
KEGG |
hsa04510 |
Focal adhesion |
KEGG |
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
hsa04917 |
Prolactin signaling pathway |
KEGG |
hsa05162 |
Measles |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
hsa05202 |
Transcriptional misregulation in cancer |
KEGG |
hsa05203 |
Viral carcinogenesis |
KEGG |
hsa05206 |
MicroRNAs in cancer |
KEGG |
WP707 |
DNA Damage Response |
WikiPathways |
WP399 |
Wnt Signaling Pathway and Pluripotency |
WikiPathways |
WP1991 |
SRF and miRs in Smooth Muscle Differentiation and Proliferation |
WikiPathways |
WP306 |
Focal Adhesion |
WikiPathways |
WP34 |
Ovarian Infertility Genes |
WikiPathways |
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
WP1530 |
miRNA Regulation of DNA Damage Response |
WikiPathways |
WP49 |
IL-2 Signaling Pathway |
WikiPathways |
WP45 |
G1 to S cell cycle control |
WikiPathways |
WP2261 |
Signaling Pathways in Glioblastoma |
WikiPathways |
WP179 |
Cell Cycle |
WikiPathways |
WP428 |
Wnt Signaling Pathway |
WikiPathways |
h_cellcyclePathway |
Cyclins and Cell Cycle Regulation |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0009375 |
Colonic Neoplasms |
C0011860 |
Diabetes Mellitus, Non-Insulin-Dependent |
C0016059 |
Fibrosis |
C0018800 |
Cardiomegaly |
C0033578 |
Prostatic Neoplasms |
C0151744 |
Myocardial Ischemia |
C0919267 |
Ovarian Neoplasm |
C1527249 |
Colorectal Cancer |
Database Name |
---|
DisGeNET |
Pubmed ID | Author | Year | Title |
---|---|---|---|
19141487 |
Kenigsberg et al. |
2009 |
Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients |
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CDKN2C |
1031 |
P42773 |
0.00 |
E2F3 |
1871 |
O00716 |
0.00 |
MAX |
4149 |
P61244 |
0.00 |
PITX2 |
5308 |
Q99697 |
0.00 |
SOS1 |
6654 |
Q07889 |
0.00 |
STAT2 |
6773 |
P52630 |
0.00 |
STAT3 |
6774 |
P40763 |
0.00 |
STAT5A |
6776 |
P42229 |
0.00 |
STAT5B |
6777 |
P51692 |
0.00 |
STAT6 |
6778 |
P42226 |
0.00 |
TCF7L2 |
6934 |
Q9NQB0 |
0.00 |
HIST1H1A |
3024 |
Q02539 |
0.62 |
CDKN1C |
1028 |
P49918 |
0.63 |
RBL2 |
5934 |
Q08999 |
0.63 |
RB1 |
5925 |
P06400 |
0.69 |
TSC2 |
7249 |
P49815 |
0.72 |
PCGF2 |
7703 |
P35227 |
0.77 |
CDK2 |
1017 |
P24941 |
0.83 |
CDK5 |
1020 |
Q00535 |
0.89 |
CDKN1B |
1027 |
P46527 |
0.94 |
CDK4 |
1019 |
P11802 |
0.98 |
RUNX1 |
861 |
Q01196 |
0.52 |
ABL1 |
25 |
P00519 |
0.56 |
CALM2 |
805 |
P62158 |
0.56 |
CALM3 |
808 |
P62158 |
0.56 |
PSMD10 |
5716 |
O75832 |
0.56 |
FBXL2 |
25827 |
Q9UKC9 |
0.65 |
DMTF1 |
9988 |
Q9Y222 |
0.67 |
RBX1 |
9978 |
P62877 |
0.72 |
AKAP8 |
10270 |
O43823 |
0.73 |
SERTAD1 |
29950 |
Q9UHV2 |
0.75 |
NPDC1 |
56654 |
Q9NQX5 |
0.75 |
CDKN2A |
1029 |
P42771 |
0.84 |
CDK6 |
1021 |
Q00534 |
0.88 |
CDKN1A |
1026 |
P38936 |
0.89 |