Protein Description

Gene Symbol CCND2
Entrez ID 894
Uniprot ID P30279
Description cyclin D2
Chromosomal Location chr12: 4,273,772-4,305,350
Ontology GO ID GO Term Definition Evidence

BP

GO:0001934

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

IDA

BP

GO:0007049

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

IEA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IMP

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IMP

BP

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

Any process that activates or increases the frequency, rate or extent of CDK activity.

IDA

BP

GO:0051301

cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

IEA

BP

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle.

IMP

CC

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.

IDA

CC

GO:0000785

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

Domain ID Description

IPR004367

Cyclin, C-terminal domain

IPR006671

Cyclin, N-terminal

IPR013763

Cyclin-like

IPR015451

Cyclin D

Pathway ID Pathway Term Pathway Source

hsa04068

FoxO signaling pathway

KEGG

hsa04110

Cell cycle

KEGG

hsa04115

p53 signaling pathway

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04310

Wnt signaling pathway

KEGG

hsa04340

Hedgehog signaling pathway

KEGG

hsa04390

Hippo signaling pathway

KEGG

hsa04510

Focal adhesion

KEGG

hsa04630

Jak-STAT signaling pathway

KEGG

hsa04917

Prolactin signaling pathway

KEGG

hsa05162

Measles

KEGG

hsa05166

HTLV-I infection

KEGG

hsa05202

Transcriptional misregulation in cancer

KEGG

hsa05203

Viral carcinogenesis

KEGG

hsa05206

MicroRNAs in cancer

KEGG

WP707

DNA Damage Response

WikiPathways

WP399

Wnt Signaling Pathway and Pluripotency

WikiPathways

WP1991

SRF and miRs in Smooth Muscle Differentiation and Proliferation

WikiPathways

WP306

Focal Adhesion

WikiPathways

WP34

Ovarian Infertility Genes

WikiPathways

WP710

DNA Damage Response (only ATM dependent)

WikiPathways

WP1530

miRNA Regulation of DNA Damage Response

WikiPathways

WP49

IL-2 Signaling Pathway

WikiPathways

WP45

G1 to S cell cycle control

WikiPathways

WP2261

Signaling Pathways in Glioblastoma

WikiPathways

WP179

Cell Cycle

WikiPathways

WP428

Wnt Signaling Pathway

WikiPathways

h_cellcyclePathway

Cyclins and Cell Cycle Regulation

BioCarta

UMLS CUI UMLS Term

C0009375

Colonic Neoplasms

C0011860

Diabetes Mellitus, Non-Insulin-Dependent

C0016059

Fibrosis

C0018800

Cardiomegaly

C0033578

Prostatic Neoplasms

C0151744

Myocardial Ischemia

C0919267

Ovarian Neoplasm

C1527249

Colorectal Cancer

No tissues found.

Database Name

DisGeNET

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

CDKN2C

1031

P42773

0.00

E2F3

1871

O00716

0.00

MAX

4149

P61244

0.00

PITX2

5308

Q99697

0.00

SOS1

6654

Q07889

0.00

STAT2

6773

P52630

0.00

STAT3

6774

P40763

0.00

STAT5A

6776

P42229

0.00

STAT5B

6777

P51692

0.00

STAT6

6778

P42226

0.00

TCF7L2

6934

Q9NQB0

0.00

HIST1H1A

3024

Q02539

0.62

CDKN1C

1028

P49918

0.63

RBL2

5934

Q08999

0.63

RB1

5925

P06400

0.69

TSC2

7249

P49815

0.72

PCGF2

7703

P35227

0.77

CDK2

1017

P24941

0.83

CDK5

1020

Q00535

0.89

CDKN1B

1027

P46527

0.94

CDK4

1019

P11802

0.98

RUNX1

861

Q01196

0.52

ABL1

25

P00519

0.56

CALM2

805

P62158

0.56

CALM3

808

P62158

0.56

PSMD10

5716

O75832

0.56

FBXL2

25827

Q9UKC9

0.65

DMTF1

9988

Q9Y222

0.67

RBX1

9978

P62877

0.72

AKAP8

10270

O43823

0.73

SERTAD1

29950

Q9UHV2

0.75

NPDC1

56654

Q9NQX5

0.75

CDKN2A

1029

P42771

0.84

CDK6

1021

Q00534

0.88

CDKN1A

1026

P38936

0.89